Article
Materials Science, Multidisciplinary
Lini Wang, Hui Jie Zhang, Xueqian Liu, Yun Liu, Xing Zhu, Xinhua Liu, Xiangyu You
Summary: In this study, hydrogels composed of gelatin and sodium alginate were successfully constructed through a simple acid soaking-drying-swelling process, showing good mechanical performance, biocompatibility, and ionic conductivity.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Physical
Peihong Li, Xueyan Dai, Yanlong Sui, Rui Li, Chunling Zhang
Summary: Graphene oxide composite hydrogel has unique mechanical properties and temperature stability, making it suitable for drug delivery systems.
Article
Pharmacology & Pharmacy
Qiao Yang, Xinqiao Lai, Jiandi Ling, Dongque Chen, Peng Liu, Taoyan Mao, Xiaoqin Shang, Liming Wang
Summary: This study develops a physically crosslinked hydrogel glue with outstanding adhesiveness, antibacterial activity, and suitable mechanical properties by using polyvinyl alcohol, beta-cyclodextrin, and silica nanoparticles. The composite gel showed tunable mechanical strengths, high swelling ratio, and significant antibacterial property, demonstrating the potential of pure physical strategy for preparing high-performance antibacterial hydrogel glues.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Yulin Zhang, Shiyu Wang, Yi Tian, Long Chen, Yuhan Du, Gehong Su, Yu Hu
Summary: This study successfully synthesized hydrogel sensors with excellent mechanical and self-healing properties, and demonstrated their sensitive and stable motion sensing capabilities as conductive sensors.
Article
Polymer Science
Yanjie Wang, Wei Yu, Sijun Liu
Summary: A robust physically cross-linked hydrogel with excellent mechanical properties and biocompatibility has been developed for cartilage repair. In vivo evaluation in an animal model demonstrates the potential of this hydrogel in promoting cartilage defect repair.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Wei Li, Chengshi Wang, Zhenghao Wang, Liping Gou, Ye Zhou, Ge Peng, Min Zhu, Jiayi Zhang, Ruoqing Li, Hengfan Ni, Lei Wu, Wanli Zhang, Jiaye Liu, Yali Tian, Zhong Chen, Yuan-Ping Han, Nanwei Tong, Xianghui Fu, Xiaofeng Zheng, Per-Olof Berggren
Summary: A novel bioscaffold ILGel was developed to accelerate diabetic alveolar bone injury healing, promoting M2 macrophage polarization and osteogenesis through sustained release of IL-10 cytokine. The findings suggest the potential application of DNA hydrogel bioscaffold for cytokine-based immunotherapy in diabetic alveolar bone injury and other periodontal diseases.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Mingqi Chen, Yande Cui, Yixiang Wang, Chunyu Chang
Summary: In this study, high-performance anisotropic hydrogels were developed to mimic the ordered structure of skeletal muscles. These hydrogel artificial muscles exhibited high actuation stroke and high work capacity, and their output efficiency was comparable to natural muscles.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cell Biology
Agnes E. Haggerty, Ines Maldonado-Lasuncion, Yohshiro Nitobe, Kentaro Yamane, Megan M. Marlow, Hua You, Chi Zhang, Brian Cho, Xiaowei Li, Sashank Reddy, Hai-Quan Mao, Martin Oudega
Summary: The study found that combining MSC and NHC for treating spinal cord injuries can reduce the number of inflammatory cells, promote a shift from pro-inflammatory to anti-inflammatory environment at the injury site, decrease injury size, increase the presence of astrocytes and axons, but has no significant impact on MSC transplant survival and hind limb function.
Article
Pharmacology & Pharmacy
Minoo Ghanavi, Ali Khoshandam, Shaghayegh Aslzad, Marziyeh Fathi, Abolfazl Barzegari, Elaheh Dalir Abdolahinia, Khosro Adibkia, Jaleh Barar, Yadollah Omidi
Summary: Due to the unique structure of the human eye, ocular drug delivery faces challenges such as low bioavailability. In-situ gel-forming mucoadhesive hydrogels can improve ocular bioavailability. Chitosan has been used in the preparation of these hydrogels. Water-soluble chitosan was obtained and gel formation was accomplished using sodium beta-glycerophosphate and sodium bicarbonate. The prepared hydrogel showed sustained-release and antibacterial activity in vitro.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Lanting Wei, Xiang Wang, Junjie Fu, Jian Yin, Jing Hu
Summary: The current therapy for muscle injury is facing challenges in tissue self-regeneration and function restoration. Tissue engineering using natural polysaccharides as scaffolds shows promise in treating skeletal muscular disorders. A 3D hydrogel scaffold based on the double network of sodium alginate, chitosan, and calcium ions has been developed. The physical, mechanical, and biological properties of the hydrogel scaffold can be adjusted by altering the ratios of the components. The scaffold supports cell growth and attachment, making it a potential printable material for skeletal muscle tissue engineering.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Pharmacology & Pharmacy
Min-Hwan Kim, Ju-Hwan Park, Duy-Thuc Nguyen, Sungyun Kim, Da In Jeong, Hyun-Jong Cho, Dae-Duk Kim
Summary: An HAase inhibitor-incorporated hyaluronic acid hydrogel was designed to reduce toxicity risk and slow biodegradation rate in subcutaneous tissue. The hydrogel, formulated with Quercetin as an HAase inhibitor and quetiapine as a model drug, exhibited sustained drug release and improved pharmacokinetic parameters in rats following subcutaneous injection. All results supported the designed hydrogel as a biocompatible formulation for sustained drug delivery.
Article
Engineering, Environmental
Hui Peng, Xiaojie Gao, Kanjun Sun, Xuan Xie, Guofu Ma, Xiaozhong Zhou, Ziqiang Lei
Summary: The study shows that dual-network hydrogel electrolytes have better tensile properties and temperature tolerance, delivering high capacities over a wide temperature range, and exhibiting excellent self-healing ability.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Le Hu, Yuxin Wang, Qing Liu, Man Liu, Faming Yang, Chunxiao Wang, Panpan Pan, Lin Wang, Li Chen, Jingdi Chen
Summary: In this study, a biocompatible dual-network composite hydrogel sensor was developed to monitor human health in real-time and accelerate wound healing. The hydrogel exhibited good biocompatibility in vitro and effectively facilitated wound healing in vivo, while also monitoring human movement. This work opens up new possibilities in the field of smart medicine.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Applied
Min Wu, Xiaoxia Chen, Jiatong Xu, Hongbin Zhang
Summary: In this study, transparent organogels and opaque hydrogels derived from curdlan were prepared using the freeze-thaw technique and a solvent-exchange strategy. The mechanical and structural properties of these gels were investigated, and the use of DMSO as a crosslinker and pore-foaming agent in organogels was explored. The reversible conformation changes and phase separation of curdlan endowed the gels with reversible transparency and tunable mechanical strength. This design strategy provides a platform for developing new organogels and sterile hydrogels of curdlan.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Zhixiang Cai, Yanmei Tang, Yue Wei, Pengguang Wang, Hongbin Zhang
Summary: Various studies have shown that physical anti-adhesion barriers like hydrogels can effectively reduce or prevent postsurgical peritoneal adhesions, while the use of chemical cross-linkers in chemical hydrogels may lead to cytotoxicity or unwanted side effects. A physically cross-linked hyaluronan cryogel was developed as a novel anti-adhesion biomaterial, demonstrating excellent biocompatibility and preventing fibroblast penetration, with the ability to inhibit inflammatory responses and modulate the fibrinolytic system to prevent peritoneal adhesions.
Article
Psychology, Multidisciplinary
Nicolas Mascret, Olivier Vors, Tanguy Marqueste, Francois Cury
Summary: This study used the TSST as an experimental stress paradigm to investigate its impact on free-throw performance of skilled basketball players. The results showed that free-throw performance remained stable when players were put in a competition immediately after the TSST, and other-approach goals were significant predictors of performance in the competition condition.
PSYCHOLOGICAL REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Noemie Gil, Constance Thomas, Rana Mhanna, Jessica Mauriello, Romain Maury, Benjamin Leuschel, Jean-Pierre Malval, Jean-Louis Clement, Didier Gigmes, Catherine Lefay, Olivier Soppera, Yohann Guillaneuf
Summary: Researchers have found that by adding dibenzo[c,e]-oxepane-5-thione (DOT) to acrylate-based resins, weak bonds can be introduced into the materials used in 3D printing, making them biodegradable. The small amount of additive does not significantly affect the printability, resolution, and mechanical properties of the resin. The resin with additive can be used in different photolithography setups and degrades in solvents and compost, with the rate of degradation depending on the size of the object. This study opens up new possibilities for creating easily soluble 3D objects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Paul Galanopoulo, Noemie Gil, Didier Gigmes, Catherine Lefay, Yohann Guillaneuf, Maelle Lages, Julien Nicolas, Muriel Lansalot, Franck D'Agosto
Summary: Aqueous emulsion copolymerizations of dibenzo[c,e]oxepane-5-thione (DOT) with n-butyl acrylate (BA), styrene (S) and a combination of both were successfully performed. DOT showed limited solubility in BA compared to S, resulting in a more homogeneous integration of DOT units in the latex. Emulsion terpolymerization also produced stable latexes with a broad range of glass transition temperatures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Shovan Mondal, Frederic Dumur, Didier Gigmes, Mukund P. Sibi, Michele P. Bertrand, Malek Nechab
Summary: Benefiting from the increase in fundamental knowledge, there has been a continuous burst of new ideas and catalytic methods for enantioselective radical reactions in the past 20 years. This review provides a comprehensive survey of the progress achieved during this period, focusing on chiral organocatalysts and transition-metal redox catalysis. The review also discusses the merger of photocatalysis with organo- or metalla-photocatalysis and enzyme-catalyzed reactions involving radical intermediates.
Article
Chemistry, Physical
Thi Khanh Ly Nguyen, Trang N. T. Phan, Fabrice Cousin, Didier Devaux, Sumit Mehan, Fabio Ziarelli, Stephane Viel, Didier Gigmes, Priscillia Soudant, Renaud Bouchet
Summary: This paper focuses on increasing the lithium transport number by synthesizing POSS-based macroanions and studying their properties in electrolytes. It is found that the size of macroanions has a significant impact on transport number, electrolyte viscosity, and tortuosity. The chemical affinity between the organic POSS shell and the solvent also affects the dissociation rate of Li+ ions.
CHEMISTRY OF MATERIALS
(2022)
Article
Polymer Science
Noemie Gil, Baptiste Caron, Didier Siri, Julien Roche, Slim Hadiouch, Douriya Khedaioui, Stephane Ranque, Carole Cassagne, Damien Montarnal, Didier Gigmes, Catherine Lefay, Yohann Guillaneuf
Summary: In this study, degradable high molar mass polystyrene was successfully prepared by incorporating a cyclic monomer into the polymer backbone through copolymerization. The thermal and mechanical properties of the polystyrene were not significantly altered. Moreover, the degraded polystyrene could be broken down into soluble oligomers through catalysis and base activation. The research demonstrated the potential applications of this copolymerization system in the phototriggered decomposition of polystyrene in solution and the degradation of cross-linked polystyrene networks into soluble side products.
Article
Chemistry, Multidisciplinary
Paul Galanopoulo, Noemie Gil, Didier Gigmes, Catherine Lefay, Yohann Guillaneuf, Maelle Lages, Julien Nicolas, Franck D'Agosto, Muriel Lansalot
Summary: Poly(N-acryloylmorpholine) (PNAM)-decorated waterborne nanoparticles with degradable cores of either polystyrene (PS) or poly(n-butyl acrylate) (PBA) were synthesized by polymerization-induced self-assembly (PISA) in water. Well-defined amphiphilic block copolymers were obtained by extending a PNAM bearing a trithiocarbonate chain end (PNAM-TTC) via reversible addition-fragmentation chain transfer (RAFT)-mediated emulsion copolymerization. The in situ self-assembly of these polymers led to the formation of stable nanoparticles. Additionally, the insertion of thioester units in the vinylic blocks enabled their degradation under basic conditions. The same strategy was applied to the emulsion copolymerization of PBA with dibenzo[c,e]oxepane-5-thione (DOT) using a poly(ethylene glycol) (PEG) equipped with a trithiocarbonate end group, resulting in PEG-decorated nanoparticles with degradable PBA-based cores.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Materials Science, Multidisciplinary
Jessica Mauriello, Romain Maury, Yohann Guillaneuf, Didier Gigmes
Summary: Vat photopolymerization is a method that utilizes light-induced polymerization to create targeted structures from liquid photopolymers. Polyurethanes have gained significant attention in the industrial and academic fields due to their various properties. This review article highlights recent progress in printing techniques, resin compositions, and applications of 3D/4D printing using vat photopolymerization of polyurethanes.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Yijun Zhang, Zheng Liu, Timur Borjigin, Bernadette Graff, Fabrice Morlet-Savary, Michael Schmitt, Didier Gigmes, Frederic Dumur, Jacques Lalevee
Summary: Seventeen carbazole-fused coumarin-based oxime esters were developed as efficient and visible light-absorbing initiators for polymerization. Certain oxime esters exhibited comparable or better photoinitiation performance than the benchmark photoinitiator under LED irradiation. These oxime esters also showed thermal initiation behavior and could be used as both thermal and photo-initiators. Moreover, two oxime esters, OXE-1 and OXE-5, were found to be sunlight activable and achieved high monomer conversion rates within one hour.
Article
Chemistry, Physical
Nataliya Kalashnyk, Adam Hassan Denawi, Frederic Dumur, Didier Gigmes, Xavier Bouju, Sylvain Clair
Summary: The supramolecular self-assembly of s-indacene-1,3,5,7(2H,6H)-tetrone on the Cu(111) surface was investigated and six different phases were found, driven by different interactions. Host-guest interactions allowed for the accommodation of molecular or metal clusters inside the nanoporous patterns. Three metal-organic networks led to the creation of regular arrays of isolated metal adatoms or adatom clusters.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Polymer Science
Paul Galanopoulo, Laura Sinniger, Noemie Gil, Didier Gigmes, Catherine Lefay, Yohann Guillaneuf, Maelle Lages, Julien Nicolas, Franck D'Agosto, Muriel Lansalot
Summary: Degradable poly(methyl methacrylate) (PMMA) particles were synthesized using radical emulsion polymerization in water, with a cyclic ketene acetal, 5,6-benzo-2-methylene-1,3-dioxepane (BMDO), as a co-monomer. The stability of BMDO in aqueous media and the degradation mechanism were studied to understand its use in emulsion and its incorporation into the copolymer chains. Stable latexes with varying amounts of BMDO inserted units (2-6.4 mol%) were obtained, and the resulting copolymer exhibited an average molar mass loss of 90% during degradation in a basic medium.
Article
Chemistry, Organic
Fengbo Liu, Amine Kriat, Roselyne Rosas, David Berge-Lefranc, Didier Gigmes, Simon Pascal, Olivier Siri, Simin Liu, Anthony Kermagoret, David Bardelang
Summary: This study investigates the formation of complexes between the guest molecule VPI and cucurbit[8]uril (CB[8]) and cucurbit[10]uril (CB[10]). The introduction of different structural features in VPI analogues reveals the mechanisms behind the formation of these complexes, with more hydrophobic guests resulting in more stable complexes with CB[8]. The control of guest stacking through the self-assembly of synthetic hosts provides insight into the formation of supramolecular structures.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Fatima Hussein, Corentin Pigot, Francisco Romero Lairado, Marco Minissale, Eric Salomon, Thierry Angot, Frederic Dumur, Malek Nechab, Didier Gigmes, Sylvain Clair, Luca Giovanelli
Summary: On-surface synthesis is an important tool for building covalently bonded molecular nanostructures and offers new synthetic pathways. This study investigates the adsorption behavior of a chiral molecule on a metal surface, demonstrating the formation of low-dimensional structures through activated homocoupling reactions and showcasing adsorption-induced chiral inversion.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Polymer Science
Hien The Ho, Veronique Montembault, Sagrario Pascual, Laurent Fontaine, Didier Gigmes, Trang N. T. Phan
Summary: A novel alkyl iodide compound was synthesized and used as an initiator for polymerization reactions. The new initiator showed high efficiency in producing functional polymers through thermal and photochemical activation.
Article
Polymer Science
Aurelien Vebr, Magali Dallegre, Laurent Autissier, Charlotte Drappier, Karel Le Jeune, Didier Gigmes, Anthony Kermagoret
Summary: This study successfully controlled the thermal properties of PVC by initiating the polymerization of acrylate monomers on azide-modified PVC through copper catalysis. The resulting copolymers exhibited different glass transition temperatures and semi-crystalline behavior.