Article
Pharmacology & Pharmacy
Mario Saletti, Marco Paolino, Lavinia Ballerini, Germano Giuliani, Gemma Leone, Stefania Lamponi, Marco Andreassi, Claudia Bonechi, Alessandro Donati, Daniele Piovani, Alberto Giacometti Schieroni, Agnese Magnani, Andrea Cappelli
Summary: An easy and viable crosslinking procedure using click-chemistry was developed for hyaluronic acid. The resulting crosslinked materials showed no cytotoxic effects, tunable water affinity, and rheological properties, suggesting potential applications in different biomedical fields.
Article
Chemistry, Analytical
Tao Yao, Jiejie Feng, Changshun Chu, Zhanfang Ma, Hongliang Han
Summary: A novel cascade controlled release system was proposed for the electrochemical detection of tumor marker, utilizing pH-responsive ZIF-8 capsule and enzyme-responsive hyaluronic acid hydrogel. This system showed excellent analytical performance with a wide range and ultralow detection limit, opening up new perspectives for controlled release systems in electrochemical sensing applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Nanoscience & Nanotechnology
Hao Zhang, Ping Zhou, Yi Jiang, Liu Li, Fei Ju, Quan Cheng, You Lang Zhou, Yuan Zhou
Summary: A nanosized drug delivery system based on PLGA nanoparticles and HA hydrogel was developed for sustained-release of esketamine, which effectively attenuated neuropathic pain without obvious adverse reactions. The mechanism might be related to modulating the activation of spinal cord astrocytes and inhibiting the excitability of dorsal root ganglion neurons.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Pengxiang Xu, Jiangfeng Song, Zhuqing Dai, Yayuan Xu, Dajing Li, Caie Wu
Summary: The study investigated the construction of nano-lutein hydrogels with sustained release properties by cross-linking with different concentrations of Ca2+. Results showed that the highest loading capacity for lutein reached 770.88 μg/g, with an encapsulation efficiency of 99.39%. The presence of lutein nanoparticles and increased Ca2+ concentration both affected the physical properties and swelling behavior of the hydrogel. The stability of cross-linked ionic bonds in the hydrogel was reduced by lutein nanoparticles and excessive Ca2+, impacting its thermodynamic stability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Sara Bagheri, Zohreh Bagher, Sajad Hassanzadeh, Sara Simorgh, Seyed Kamran Kamrava, Vajihe Taghdiri Nooshabadi, Ronak Shabani, Maryam Jalessi, Mehdi Khanmohammadi
Summary: This study evaluated the effect of different degrees of cross-linked Ph moieties on cellular adhesiveness and proliferation on the resultant enzymatically cross-linked HA-Ph hydrogels. The results showed that hydrogels with a higher degree of Ph moieties exhibited better cell attachment, spreading, and proliferation, making them suitable biomaterials for biomedical and tissue engineering applications.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Nanoscience & Nanotechnology
Qiong Yuan, Yantao Zhao, Ziqi Zhang, Yanli Tang
Summary: This study presents a novel hyaluronidase-responsive nanoparticle for on-demand release of antimicrobial agents, demonstrating excellent biocompatibility and antibacterial activity. The nanoparticles can be triggered to release antibacterial agents by hyaluronidase secreted by MRSA, leading to bacterial death by disrupting cell membranes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Dariush Nikjoo, Ires van der Zwaan, Jonas Ruden, Goran Frenning
Summary: This study aimed to produce microparticles of hyaluronic acid hydrogel loaded with salbutamol sulphate for controlled release in the lung. The drug-loaded microparticles were successfully prepared and showed improved aerodynamic properties compared to unloaded microparticles. In vitro drug release studies confirmed the potential of these particles to release the drug in a sustained manner.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Pablo Ramos Ferrer, Sangamithra Vardhan, Shelly Sakiyama-Elbert
Summary: The goal of this study was to design a polymer-based platform for localized, long-term delivery of neurotrophic factors using an affinity-based approach. HA-mF hydrogels were synthesized to provide sustained release of NT-3, a growth factor promoting axon growth, for 28 days. These hydrogels can be polymerized in the presence of cells and growth factors, and demonstrate bioactivity and support cell growth, making them an excellent platform for neural growth factor delivery.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Biochemistry & Molecular Biology
Sandip P. Patil, Leena P. Shirsath, Bhushan L. Chaudhari
Summary: A halotolerant bacterium isolated from dental caries was found to produce the enzyme hyaluronidase, which showed high activity and stability at pH 7.0 and 40 degrees C, as well as in 2M NaCl solution. The enzyme exhibited wide substrate specificity with hyaluronic acid as the best substrate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Nam-Gyun Kim, Pathum Chandika, Se-Chang Kim, Dong-Hoon Won, Won Sun Park, Il-Whan Choi, Sang Gil Lee, Young-Mog Kim, Won-Kyo Jung
Summary: The use of self-healing hydrogels in wound dressings can protect them from mechanical damage and extend their lifespan. In this study, a hydrogel with rapid self-healing properties and high antibacterial activity was fabricated by testing different mixing ratios of hyaluronic acid (HA) and pectin (PT) using Fe3+ cross-linking. The optimal Fe3+-cross-linked HA/PT hydrogel showed potential for wound-healing applications due to its self-healing properties and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.
Review
Biochemistry & Molecular Biology
Aditya Kaul, Walker D. Short, Xinyi Wang, Sundeep G. Keswani
Summary: This article discusses the important role of hyaluronidases in human tissues, especially in promoting disease progression, and the potential benefits as clinical treatments currently and in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nae-Won Kang, So-Yeon Yoon, Sungho Kim, Na-Young Yu, Ju-Hwan Park, Jae-Young Lee, Hyun-Jong Cho, Dae-Duk Kim
Summary: The study developed a hybrid hydrogel containing microstructured lipid carriers and human serum albumin for sustained release of donepezil, which prolonged drug release and reduced initial plasma concentration in rats. The hydrogel exhibited good biocompatibility and therapeutic efficacy.
Review
Engineering, Biomedical
Fernanda Zamboni, Chun Kwok Wong, Maurice N. Collins
Summary: This article discusses the interaction between hyaluronic acid and pathogenic microorganisms, as well as the antimicrobial activity of different molecular weights of hyaluronic acid in biomedical and pharmaceutical applications. These studies are crucial for the development of next generation antimicrobial therapeutic strategies.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jae Yoon An, Wooram Um, Dong Gil You, Yeari Song, Jeongjin Lee, Nguyen Van Quy, Hyeyeon Joo, Jueun Jeon, Jae Hyung Park
Summary: A novel hyaluronic acid hydrogel-based depot with ultrasound-triggered thermal elevation and on-demand cargo release for cancer therapy was reported in this study. The results demonstrated that the hydrogel significantly increased temperature and released cargo under ultrasound, showing potential for in vivo applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Yuning Luo, Junyan Tan, Yue Zhou, Yuqiong Guo, Xinying Liao, Li He, Dingxilei Li, Xinxin Li, Yang Liu
Summary: Hyaluronic acid (HA) is a natural polysaccharide with excellent biocompatibility and moisturizing effect, which can affect angiogenesis, inflammation, and cell behavior. HA-based hydrogels formed by physical or chemical crosslinking strategies have both the physiological function of HA and the skeleton function of hydrogel. However, natural HA-based hydrogels have limitations such as insufficient mechanical strength and susceptibility to degradation. Researchers have developed various HA-based multifunctional hydrogels with notable properties by modifying the structure, using novel crosslinking strategies, and introducing reactive molecules. These hydrogels have extended the application scope in anticancer drug delivery, cartilage repair, three-dimensional cell culture, skin dressing, and other fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
JunHyung Lee, Abdolreza Hosseindoust, MinJu Kim, KwangYeol Kim, YoHan Choi, SeokHee Lee, SongYi Lee, HyunJong Cho, Wei Soo Kang, ByungJo Chae
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Nae-Won Kang, Jae-Young Lee, Kwangho Song, Min-Hwan Kim, Soyeon Yoon, Duy-Thuc Nguyen, Sungho Kim, Yeong Shik Kim, Dae-Duk Kim
Article
Pharmacology & Pharmacy
Min-Hwan Kim, Dong Hyun Kim, Duy-Thuc Nguyen, Han Sol Lee, Nae-Won Kang, Min-Jun Baek, Jiseon An, So-Yeol Yoo, Yong-Hyeon Mun, Wonhwa Lee, Ki-Taek Kim, Cheong-Weon Cho, Jae-Young Lee, Dae-Duk Kim
Article
Pharmacology & Pharmacy
Chao-Feng Mu, Fude Cui, Yong-Mei Yin, Hyun-Jong Cho, Dae-Duk Kim
Article
Pharmacology & Pharmacy
Nae-Won Kang, So-Yeon Yoon, Sungho Kim, Na-Young Yu, Ju-Hwan Park, Jae-Young Lee, Hyun-Jong Cho, Dae-Duk Kim
Summary: The study developed a hybrid hydrogel containing microstructured lipid carriers and human serum albumin for sustained release of donepezil, which prolonged drug release and reduced initial plasma concentration in rats. The hydrogel exhibited good biocompatibility and therapeutic efficacy.
Review
Pharmacology & Pharmacy
Min-Hwan Kim, Duy-Thuc Nguyen, Dae-Duk Kim
Summary: HA-based hydrogel formulations have been widely used for drug delivery due to their non-toxicity, biocompatibility, and rheological properties. However, challenges such as initial burst drug release and lack of mechanical strength have led to the investigation of various strategies to control drug release. Recent approaches include chemical and non-covalent cross-linking methods, ionic cross-linking, host-guest interactions, and incorporation of drug powders and nanoparticles in hydrogel networks to sustain drug release. These strategies aim to enhance the versatility of clinical applications for HA-based hydrogel formulations in various biomedical areas.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Article
Nanoscience & Nanotechnology
Duy-Thuc Nguyen, Min-Hwan Kim, Na-Young Yu, Min-Jun Baek, Kyung-Sun Kang, Ki Won Lee, Dae-Duk Kim
Summary: A novel bentonite-based composite formulation of orobol was prepared and found to significantly enhance the deposition of orobol in the skin. The addition of phosphatidylcholine improved the dissolution and release of orobol. Physicochemical characterizations and toxicity studies confirmed the safety and biocompatibility of the formulation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Min-Jun Baek, Duy-Thuc Nguyen, Dahan Kim, So-Yeol Yoo, Sang Min Lee, Jae-Young Lee, Dae-Duk Kim
Summary: The study presents the design of a tailored structure for renal-clearable zwitterionic cyclodextrin for selective drug delivery in colorectal cancer. Twenty cyclodextrin derivatives were synthesized and screened for colloidal stability, resulting in five candidates that were evaluated for biodistribution and an optimized structure was identified. The optimized cyclodextrin demonstrated high tumour accumulation and improved antitumour efficacy in colorectal cancer models.
NATURE NANOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Nae-Won Kang, Voradanu Visetvichaporn, Duy-Thuc Nguyen, Eun Kyung Shin, Dahan Kim, Min-Jae Kim, So-Yeol Yoo, Jae-Young Lee, Dae-Duk Kim
Summary: The study reports bone tumor-targeting polymeric nanotherapeutics named PLCSA-AD, which showed prolonged retention in tumor microenvironment and enhanced therapeutic efficacy by inhibiting the mevalonate pathway. In vivo experiments demonstrated that PLCSA-AD significantly increased tumor accumulation and improved therapeutic efficacy.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Hyun-Jong Cho
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2020)