Article
Multidisciplinary Sciences
Alisa M. Gorbacheva, Aksinya N. Uvarova, Alina S. Ustiugova, Arindam Bhattacharyya, Kirill Korneev, Dmitry Kuprash, Nikita A. Mitkin
Summary: EGR1 and RXRA transcription factors play key roles in the regulation of the CCL2 gene in response to TGF-beta, affecting breast cancer progression by controlling the activity of the CCL2 promoter.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jian Liu, Chunxiao Li, Hongsheng Xue, Lina Li, Qun Liu, Haijuan Wang, Tao Wen, Haili Qian
Summary: The study demonstrated that MTA1 is a novel nucleolar protein localized in the nucleolus and regulates pre-rRNA transcription, potentially promoting malignancies by activating pre-rRNA transcription in cancer cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Huiyan Eng, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Kanchugarakoppal S. Rangappa, Gautam Sethi, Alan Prem Kumar, Kwang Seok Ahn
Summary: This study demonstrates that 2,3,5,6-Tetramethylpyrazine (TMP) can suppress the EMT program in colon cancer cells by regulating MnSOD and related proteins, and inhibit the proliferation, migration, and invasion of tumor cells.
Article
Biochemistry & Molecular Biology
Adriana Maria Diaz-Anaya, Louise Gerard, Martine Albert, Jean-Francois Gaussin, Marielle Boonen, Jean-Pierre Gillet
Summary: ABCB5 beta is a marker protein associated with melanoma stem cells and skin progenitor cells. The study reveals that ABCB5 beta is predominantly localized to the endoplasmic reticulum and is degraded by the proteasome system. Treatment with SAHA, a molecule promoting chaperone-assisted folding, increases the expression of ABCB5 beta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hassan Dianat-Moghadam, Mostafa Khalili, Mohsen Keshavarz, Mehdi Azizi, Hamed Hamishehkar, Reza Rahbarghazi, Mohammad Nouri
Summary: The study investigated the impact of LXR on the tumorgenicity of human colorectal CD133 cells by incubating them with LXR agonist and antagonist. Activation of LXR up-regulated ABC transporters expression, but suppressed proliferation, clonogenicity, and migration of CD133 cells. Inhibition of LXR decreased metabolic enzyme levels and increased intracellular ROS, inducing apoptotic changes in cancer stem cells. The regulation of LXR activity may potentially target survival, metabolism, and migration in CSCs to control tumorigenesis and metastasis in advanced colorectal cancers.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Sneha M. Pinto, Yashwanth Subbannayya, Hera Kim, Lars Hagen, Maria W. Gorna, Anni I. Nieminen, Magnar Bjoras, Terje Espevik, Denis Kainov, Richard K. Kandasamy
Summary: The COVID-19 pandemic remains a global health concern due to the emergence of new variants. Extensive evidence from multi-Omics studies has revealed host-pathogen interactions and potential therapeutic targets. Understanding the regulation of host signaling networks by post-translational modifications and their impact on cellular dynamics is crucial for advancing knowledge on SARS-CoV-2 infections.
Article
Pharmacology & Pharmacy
Kelly Ascencao, Nahzli Dilek, Fiona Augsburger, Theodora Panagaki, Karim Zuhra, Csaba Szabo
Summary: Hydrogen sulfide (H2S) is an important endogenous gaseous transmitter mediator that regulates cellular functions. In cancer cells, overproduction of H2S has been linked to processes such as metabolism stimulation and cell proliferation. By inhibiting H2S biosynthesis in colon cancer cells, a shift towards MET was induced, potentially contributing to anti-cancer effects.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Long Jiao, Roman Eickhoff, Antje Egners, Sandra Jumpertz, Johanna Roth, Merve Erdem, Andreas Kroh, Hans Duimel, Carmen Lopez-Iglesias, Pilar Caro, Lara R. Heij, Maximilian Schmeding, David Meierhofer, Ulf P. Neumann, Thorsten Cramer
Summary: mTOR pathway activation is common in cancer, but mTOR inhibitors have not shown significant antiproliferative efficacy in most cancer types. Research on mTOR inhibition in hepatocytes reveals that non-malignant host cells may contribute to resistance against mTOR inhibitors.
JOURNAL OF PATHOLOGY
(2021)
Article
Oncology
Hong Xu, Shujun Zeng, Yingmei Wang, Tong Yang, Minmin Wang, Xuan Li, Yejun He, Xin Peng, Xia Li, Qing Qiao, Jing Zhang
Summary: Therapeutic resistance is a common cause of death in ovarian carcinoma patients. Polyploid giant cancer cells (PGCCs) are believed to play a role in drug resistance following chemotherapy. Sirtuin1 (SIRT1), a type III deacetylase, is involved in cell cycle, cellular senescence, and drug resistance. This study investigated the impact of SIRT1 subcellular localization on PGCC formation, senescence escape, and response to paclitaxel treatment in ovarian carcinoma cells. The results indicated that cytoplasmic SIRT1 affects PGCC formation and survival, contributing to paclitaxel resistance.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Biochemistry & Molecular Biology
Jirina Hofmanova, Josef Slavik, Miroslav Ciganek, Petra Ovesna, Zuzana Tylichova, Martina Karasova, Ondrej Zapletal, Nicol Strakova, Jirina Prochazkova, Jan Bouchal, Zdenek Kolar, Jiri Ehrmann, Monika Levkova, Zlatka Huskova, Pavel Skalicky, Alois Kozubik, Miroslav Machala, Jan Vondracek
Summary: The development of colon cancer is accompanied by significant lipid alterations, particularly in terms of fatty acid profiles within tumor cells. These changes are associated with increased expression of fatty acid synthesis genes and altered expression of enzymes involved in fatty acid elongation and desaturation. Additionally, specific lysophospholipids and corresponding phospholipids show significant changes in ratios, with upregulation of long-chain and very-long chain fatty acids in tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pei-Yi Chu, Hsing-Ju Wu, Shin-Mae Wang, Po-Ming Chen, Feng-Yao Tang, En-Pei Isabel Chiang
Summary: The methionine cycle plays a crucial role in cancer cell proliferation and metabolic reprogramming. High levels of MAT2A in breast cancer patients are associated with worse survival rates, while an elevated MAT2A C/N ratio indicates increased invasiveness in breast cancer cells, making it a potential independent prognostic marker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Xiao Li, Wei Liu, Chong Geng, Tingting Li, Yanni Li, Yaoyu Guo, Chunhui Wang
Summary: This study demonstrated that Ginsenoside Rg3 could effectively inhibit colon cancer cell invasion and metastasis by suppressing the Notch-Hes1-EMT signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Plant Sciences
Xinglong Su, Fei Meng, Yingying Liu, Weimin Jiang, Zhaojian Wang, Liping Wu, Xiaohu Guo, Xiaoyan Yao, Jing Wu, Zongping Sun, Liangping Zha, Shuangying Gui, Daiyin Peng, Shihai Xing
Summary: This study identified a beta-glucosidase in Platycodon grandiflorus that can convert platycoside E to platycodin D. The expression level of the enzyme was higher at night than during the day and was regulated by light. These findings are important for further studying the biosynthesis and metabolism regulation of triterpenoid saponins in P. grandiflorus.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Shun Li, David Mark Pritchard, Lu-Gang Yu
Summary: Galectin-3, commonly overexpressed in many epithelial cancers, is shown to promote cancer development, progression, and metastasis. This study reveals that galectin-3 secretion by human colon cancer cells induces the secretion of proteases, leading to disruption of epithelial monolayer integrity and increased permeability, ultimately promoting tumor cell invasion. This effect is mediated through cellular PYK2-GSK3 alpha/beta signaling and can be prevented by galectin-3 binding inhibitors. These findings highlight the importance of galectin-3 as a potential therapeutic target for cancer treatment.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Valerie Jooste, Leila Bengrine-Lefevre, Sylvain Manfredi, Valerie Quipourt, Pascale Grosclaude, Olivier Facy, Come Lepage, Francois Ghiringhelli, Anne-Marie Bouvier
Summary: Real-world data on the management and outcomes of pancreatic cancer showed that only half of elderly patients aged 75-84 with a surgically resectable tumor actually underwent resection, and a significant percentage of patients aged >= 85 refused chemotherapy, highlighting the need for expanded geriatric assessments.
Review
Cell Biology
Laura Kalfeist, Loick Galland, Fanny Ledys, Francois Ghiringhelli, Emeric Limagne, Sylvain Ladoire
Summary: Glucocorticoids are widely prescribed drugs in cancer patients due to their anti-inflammatory, anti-oedema, and anti-allergy properties. They are used in various clinical situations in oncology, including managing cancer-related symptoms and preventing or treating side effects or immune-related adverse events of anti-cancer therapies. Moreover, glucocorticoids have been found to affect immune response and tumor efficacy.
Article
Multidisciplinary Sciences
Marie Bobowski-Gerard, Clemence Boulet, Francesco P. Zummo, Julie Dubois-Chevalier, Celine Gheeraert, Mohamed Bou Saleh, Jean-Marc Strub, Amaury Farce, Maheul Ploton, Loic Guille, Jimmy Vandel, Antonino Bongiovanni, Ninon Very, Eloise Woitrain, Audrey Deprince, Fanny Lalloyer, Eric Bauge, Lise Ferri, Line-Carolle Ntandja-Wandji, Alexia K. Cotte, Corinne Grangette, Emmanuelle Vallez, Sarah Cianferani, Violeta Raverdy, Robert Caiazzo, Viviane Gnemmi, Emmanuelle Leteurtre, Benoit Pourcet, Rejane Paumelle, Kim Ravnskjaer, Guillaume Lassailly, Joel T. Haas, Philippe Mathurin, Francois Pattou, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jerome Eeckhoute
Summary: The transcription factor Basonuclin 2 (BNC2) is found to play a key role in driving myofibroblast activation in liver fibrosis. Its expression is induced in fibrotic livers and it integrates pro-fibrotic stimuli to induce matrisome gene expression. BNC2 deficiency leads to reduced collagen deposition in the liver. Furthermore, the study identifies a potential drug target, CC-885, as a BNC2 inhibitor.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Sylvain Ladoire, Cedric Rebe, Francois Ghiringhelli
Summary: Immune-checkpoint inhibitors have significantly impacted cancer management, but resistance remains a major issue. To overcome this, combination strategies with other therapies are being explored.
CLINICAL CANCER RESEARCH
(2023)
Review
Cell Biology
Nicolas Roussot, Francois Ghiringhelli, Cedric Rebe
Summary: The success of anticancer treatments depends on the ability of dying cancer cells under chemotherapy or physical stress to activate immune cells and stimulate an antitumor response. This can be achieved through the release of danger-associated molecular patterns (DAMPs) and the recruitment of CD8 T cells. However, the effectiveness of immune checkpoint blockers in reversing T-cell exhaustion is dependent on the recruitment of CD8 T cells within the tumor. Chemokines play a crucial role in CD8 T-cell recruitment. This review aims to explore the role of chemokines released during immunogenic cell death (ICD) in CD8 T-cell recruitment and antitumor response, as well as their potential clinical applications.
Article
Oncology
Michele Beniey, Audrey Hubert, Takrima Haque, Alexia Karen Cotte, Nelly Bechir, Xiaomeng Zhang, Danh Tran-Thanh, Saima Hassan
Summary: This study evaluated the impact of the concurrent combination of talazoparib and carboplatin on cell survival and metastasis in TNBC cells, and found that the concurrent application of these two drugs had a synergistic effect on the majority of TNBC cell lines. Additionally, the sequential combination of talazoparib and carboplatin significantly inhibited cell migration, invasion, and lung micrometastasis in a BRCA(WT) TNBC model.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
David Bonnin, Sylvain Ladoire, Nathalie Briot, Aurelie Bertaut, Clement Drouet, Alexandre Cochet, Jean-Louis Alberini
Summary: This study aimed to assess the diagnostic performance of FDG-PET/CT scanning in women previously treated for invasive lobular carcinoma with suspected first recurrence and evaluate its impact on treatment changes and prognostic value. The results showed that FDG-PET/CT is an effective tool for detecting recurrence of invasive lobular carcinoma, although certain specific recurrence sites may impair its diagnostic performance.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Loick Galland, Nicolas Roussot, Isabelle Desmoulins, Didier Mayeur, Coureche Kaderbhai, Silvia Ilie, Audrey Hennequin, Manon Reda, Juliette Albuisson, Laurent Arnould, Romain Boidot, Caroline Truntzer, Francois Ghiringhelli, Sylvain Ladoire
Summary: Breast cancer is the most common cancer in the world, and advancements in technology allow for the identification of specific molecular alterations in tumor cells, leading to new treatment options. This review summarizes the clinical utility of genomic tests in evaluating homologous recombination repair deficiency for breast cancer treatment decisions.
Article
Oncology
Nesrine Mabrouk, Cindy Racoeur, Jingxuan Shan, Aurelie Massot, Silvia Ghione, Malorie Privat, Lucile Dondaine, Elise Ballot, Caroline Truntzer, Romain Boidot, Francois Hermetet, Valentin Derangere, Melanie Bruchard, Frederique Vegran, Lotfi Chouchane, Francois Ghiringhelli, Ali Bettaieb, Catherine Paul
Summary: Our study aimed to test the beneficial effect of the nitric oxide donor glyceryltrinitrate (GTN) in combination with the chemotherapy drug doxorubicin in the treatment of triple-negative breast cancer (TNBC). Using a mouse model of TNBC, we found that the combination of the two drugs induced greater tumor regression compared to monotherapies, which was correlated with stronger activation of the immune system and a decrease in immunosuppressive immune cells. These findings suggest a new therapeutic perspective for TNBC treatment.
Article
Imaging Science & Photographic Technology
Julien Odet, Julie Pellegrinelli, Olivier Varbedian, Caroline Truntzer, Marco Midulla, Francois Ghiringhelli, David Orry
Summary: This study aimed to identify risk factors for local recurrence (LR) after radiofrequency (RFA) and microwave (MWA) thermoablations (TA) of colorectal cancer liver metastases (CCLM). The size of the lesions and the nearby vessel were found to be significant risk factors for LR.
JOURNAL OF IMAGING
(2023)
Meeting Abstract
Oncology
Audrey Hubert, Alexia Cotte, Nelly Bechir, Takrima Haque, Saima N. Hassan
Meeting Abstract
Oncology
Audrey Hubert, Alexia Cotte, Nelly Bechir, Takrima Haque, Saima N. Hassan
Meeting Abstract
Gastroenterology & Hepatology
Ludivine Clavreul, Alexia Cotte, Lucie Bernard, Joel Haas, Nathalie Hennuyer, An Verrijken, Luc Van Gaal, Sven Francque, Guillaume Lassailly, Bart Staels, Rejane Paumelle
JOURNAL OF HEPATOLOGY
(2022)
