Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms

A pyruvate dehydrogenase kinase inhibitor prevents retinal cell death and improves energy metabolism in rat retinas after ischemia/reperfusion injury

(2020) Kota Sato et al.   EXPERIMENTAL EYE RESEARCH

Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa

(2019) Wei Wang et al.   Cell Reports

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

(2018) Mami Morita et al.   CANCER CELL

Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

(2018) Ming-Chuan Hsu et al.   Molecular Cancer

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability

(2018) Ammaji Rajala et al.   Cell Death & Disease

Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration

(2018) Ammaji Rajala et al.   Cell Death & Disease

Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

(2018) Lolita Petit et al.   Cell Reports

Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer

(2018) Gopinath Prakasam et al.   Frontiers in Oncology

Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium

(2018) Lei Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

(2017) Qiuran Xu et al.   Molecular Cancer

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

(2017) Weier Qi et al.   NATURE MEDICINE

O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect

(2017) Yang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

(2017) Mark A Kanow et al.   eLife

Glycolytic reliance promotes anabolism in photoreceptors

(2017) Yashodhan Chinchore et al.   eLife

Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

(2017) Deborah A. Ferrington et al.   Redox Biology

Photoreceptor metabolic reprogramming provides survival advantage in acute stress while causing chronic degeneration

(2017) Thomas J. Wubben et al.   Scientific Reports

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

(2016) Talya L. Dayton et al.   GENES & DEVELOPMENT

Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration

(2016) Lijuan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Burning fat fuels photoreceptors

(2016) Raju V S Rajala et al.   NATURE MEDICINE

Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1

(2016) Jean-Sébastien Joyal et al.   NATURE MEDICINE

PKM2 and cancer: The function of PKM2 beyond glycolysis

(2016) GAOCHAO DONG et al.   Oncology Letters

Two-Step Reactivation of Dormant Cones in Retinitis Pigmentosa

(2016) Wei Wang et al.   Cell Reports

The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina

(2016) Raju V. S. Rajala et al.   Scientific Reports

Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis

(2015) Najate Aït-Ali et al.   CELL

Glucose, lactate, and shuttling of metabolites in vertebrate retinas

(2015) James B. Hurley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

(2015) Katharina Bluemlein et al.   Oncotarget

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Cancer-like metabolism of the mammalian retina

(2014) Soo Khai Ng et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Pyruvate kinase M2 and cancer: an updated assessment

(2014) Mohd Askandar Iqbal et al.   FEBS LETTERS

Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina

(2014) K. J. Lindsay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the pentose phosphate pathway in cancer

(2014) Peng Jiang et al.   Protein & Cell

Protein threading using context-specific alignment potential

(2013) J. Ma et al.   BIOINFORMATICS

Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators

(2013) Chuangxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

(2013) William J. Israelsen et al.   CELL

Nuclear PKM2 regulates the Warburg effect

(2013) Weiwei Yang et al.   CELL CYCLE

Mitochondria Contribute to NADPH Generation in Mouse Rod Photoreceptors

(2013) Leopold Adler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation

(2013) Ahmed Bettaieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells

(2013) Hongli Dong et al.   SpringerPlus

An explanation for the Warburg effect in the adult mammalian retina

(2012) Robert J Casson et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Identification of anti-retinal antibodies in patients with age-related macular degeneration

(2012) Kei Morohoshi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Seeing the Warburg effect in the developing retina

(2012) Brian P. Fiske et al.   NATURE CELL BIOLOGY

Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

(2012) G Sutendra et al.   ONCOGENE

Emerging roles of PKM2 in cell metabolism and cancer progression

(2012) Weibo Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cells

(2011) Nana-Maria Grüning et al.   Cell Metabolism

Loss of Daylight Vision in Retinal Degeneration: Are Oxidative Stress and Metabolic Dysregulation to Blame?

(2011) Claudio Punzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

A multiple-template approach to protein threading

(2011) Jian Peng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Raptorx: Exploiting structure information for protein alignment by statistical inference

(2011) Jian Peng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

(2010) C. V. Clower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Phototransduction Motifs and Variations

(2009) King-Wai Yau et al.   CELL

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE