Proline Metabolism in Tumor Growth and Metastatic Progression

Proline biosynthesis is a vent for TGFβ‐induced mitochondrial redox stress

(2020) Simon Schwörer et al.   EMBO JOURNAL

Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth

(2020) Miao Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy

(2020) Thi Yen Ly Huynh et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cancer progression is mediated by proline catabolism in non-small cell lung cancer

(2020) Yating Liu et al.   ONCOGENE

Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis

(2020) Un Yung Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kindlin-2 links mechano-environment to proline synthesis and tumor growth

(2019) Ling Guo et al.   Nature Communications

miR‐31 shuttled by halofuginone‐induced exosomes suppresses MFC‐7 cell proliferation by modulating the HDAC2/cell cycle signaling axis

(2019) Xiaojing Xia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pyrroline-5-Carboxylate Reductase 1 Accelerates the Migration and Invasion of Nonsmall Cell Lung Cancer In Vitro

(2019) Senhua Sang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Identification of lncRNA TRPM2-AS/miR-140-3p/PYCR1 axis’s proliferates and anti-apoptotic effect on breast cancer using co-expression network analysis

(2019) Tong Sun et al.   CANCER BIOLOGY & THERAPY

Collagen prolyl hydroxylation-dependent metabolic perturbation governs epigenetic remodeling and mesenchymal transition in pluripotent and cancer cells

(2019) Cristina D'Aniello et al.   CANCER RESEARCH

RASSF1A controls tissue stiffness and cancer stem‐like cells in lung adenocarcinoma

(2019) Daniela Pankova et al.   EMBO JOURNAL

P5CR1 protein expression and the effect of gene-silencing on lung adenocarcinoma

(2019) Yang She et al.   PeerJ

The Diverse Functions of Non-Essential Amino Acids in Cancer

(2019) Bo-Hyun Choi et al.   Cancers

The clinical significance of PYCR1 expression in renal cell carcinoma

(2019) Fu Weijin et al.   MEDICINE

P4HB, a Novel Hypoxia Target Gene Related to Gastric Cancer Invasion and Metastasis

(2019) Jun Zhang et al.   Biomed Research International

SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism

(2019) Shuaiyi Chen et al.   NEOPLASIA

Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma

(2019) Tianjiao Wang et al.   EBioMedicine

P4HA1/HIF1α feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer

(2019) X.P. Cao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of collagen in cancer: from bench to bedside

(2019) Shuaishuai Xu et al.   Journal of Translational Medicine

Therapeutic Targeting of MZF1‐AS1 /PARP1/E2F1 Axis Inhibits Proline Synthesis and Neuroblastoma Progression

(2019) Erhu Fang et al.   Advanced Science

PYCR1 is associated with papillary renal cell carcinoma progression

(2019) Qiu-Li Wang et al.   Open Medicine

High P4HA1 expression is an independent prognostic factor for poor overall survival and recurrent‐free survival in head and neck squamous cell carcinoma

(2019) Qun Li et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis

(2019) Zhaobing Ding et al.   JOURNAL OF HEPATOLOGY

PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer

(2019) Juhua Zhuang et al.   Journal of Translational Medicine

The Proline Cycle As a Potential Cancer Therapy Target

(2018) John J. Tanner et al.   BIOCHEMISTRY

Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin

(2018) Wei Jiang et al.   BLOOD

Halofuginone-induced autophagy suppresses the migration and invasion of MCF-7 cells via regulation of STMN1 and p53

(2018) Xiaojing Xia et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Collagen Prolyl 4-Hydroxylase as a Therapeutic Target

(2018) James D. Vasta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer

(2018) Jun Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis

(2018) Kate E.R. Hollinshead et al.   Cell Reports

MiR-122 inhibits epithelial mesenchymal transition by regulating P4HA1 in ovarian cancer cells

(2018) Yanan Duan et al.   CELL BIOLOGY INTERNATIONAL

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Prolyl-4-hydroxylase Α subunit 2 (P4HA2) expression is a predictor of poor outcome in breast ductal carcinoma in situ (DCIS)

(2018) Michael S. Toss et al.   BRITISH JOURNAL OF CANCER

Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma

(2018) Kianna Y. Elahi-Gedwillo et al.   CANCER RESEARCH

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

(2018) Piyush B. Gupta et al.   Cell Stem Cell

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

(2018) Gaofeng Xiong et al.   Nature Communications

Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma

(2018) Yingyi Ye et al.   Cancer Management and Research

PYCR1 promotes the progression of non-small-cell lung cancer under the negative regulation of miR-488

(2018) Dongchang Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation

(2017) Kouhei Tsuchida et al.   FREE RADICAL BIOLOGY AND MEDICINE

Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer

(2017) Tengyue Zeng et al.   MEDICAL ONCOLOGY

Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA

(2017) G X Feng et al.   ONCOGENE

Identification of P4HA1 as a prognostic biomarker for high-grade gliomas

(2017) Wan-ming Hu et al.   PATHOLOGY RESEARCH AND PRACTICE

A combined connectivity mapping and pharmacoepidemiology approach to identify existing medications with breast cancer causing or preventing properties

(2017) John Busby et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer

(2017) Guo-Qing Chen et al.   Cell Death & Disease

Pyrroline‑5‑carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non‑small cell lung cancer

(2017) Feng Cai et al.   Oncology Letters

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis

(2017) Patricia Juárez et al.   Oncotarget

Knockdown of P4HA1 inhibits neovascularization via targeting glioma stem cell-endothelial cell transdifferentiation and disrupting vascular basement membrane

(2017) Yiqiang Zhou et al.   Oncotarget

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

(2017) Cristina D'Aniello et al.   Stem Cells International

Vitamin C and l -Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum

(2017) Cristina D'Aniello et al.   Stem Cell Reports

Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses

(2017) James M. Phang   ANTIOXIDANTS & REDOX SIGNALING

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis

(2016) Nisebita Sahu et al.   Cell Metabolism

Halofuginone suppresses growth of human uterine leiomyoma cells in a mouse xenograft model

(2016) Faezeh Koohestani et al.   HUMAN REPRODUCTION

Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

(2016) Fabricio Loayza-Puch et al.   NATURE

P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition

(2016) Wei Xia et al.   Oncotarget

Halofuginone inhibits radiotherapy-induced epithelial-mesenchymal transition in lung cancer

(2016) Yang Chen et al.   Oncotarget

The translation factor eIF5A and human cancer

(2015) Michael B. Mathews et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A novel autoregulatory loop between the Gcn2-Atf4 pathway and L-Proline metabolism controls stem cell identity

(2015) C D'Aniello et al.   CELL DEATH AND DIFFERENTIATION

Proline metabolism and cancer

(2015) James M. Phang et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Reduced risk of pancreatic cancer associated with asthma and nasal allergies

(2015) Paulina Gomez-Rubio et al.   GUT

Halofuginone inhibits phosphorylation of SMAD-2 reducing angiogenesis and leukemia burden in an acute promyelocytic leukemia mouse model

(2015) Patricia A. Assis et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of TGF-β signaling with halofuginone can enhance the antitumor effect of irradiation in Lewis lung cancer

(2015) Runlong Lin et al.   OncoTargets and Therapy

Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism

(2015) Guo-Qing Chen et al.   Oncotarget

Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases

(2015) Audrey Lamora et al.   Oncotarget

Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

(2015) Wei Liu et al.   Scientific Reports

The miR-124-Prolyl Hydroxylase P4HA1-MMP1 axis plays a critical role in prostate cancer progression

(2015) Balabhadrapatruni V. S. K. Chakravarthi et al.   Oncotarget

Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

(2014) Gaofeng Xiong et al.   BMC CANCER

A Secreted Tyrosine Kinase Acts in the Extracellular Environment

(2014) Mattia R. Bordoli et al.   CELL

Nice Neighborhood: Emerging Concepts of the Stem Cell Niche

(2014) David T. Scadden   CELL

Expression of prolyl 4-hydroxylase beta-polypeptide in non-small cell lung cancer treated with Chinese medicines

(2014) Shu-mei Wang et al.   Chinese Journal of Integrative Medicine

Modulating the stem cell niche for tissue regeneration

(2014) Steven W Lane et al.   NATURE BIOTECHNOLOGY

Sequence selectivity of macrolide-induced translational attenuation

(2014) A. R. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

(2013) D. M. Gilkes et al.   CANCER RESEARCH

Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9

(2013) MEI LING JIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

L-Proline Induces a Mesenchymal-like Invasive Program in Embryonic Stem Cells by Remodeling H3K9 and H3K36 Methylation

(2013) Stefania Comes et al.   Stem Cell Reports

Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment

(2012) Wei Liu et al.   Autophagy

Proline dehydrogenase (oxidase) in cancer

(2012) Wei Liu et al.   BIOFACTORS

Halofuginone inhibits multiple myeloma growth in vitro and in vivo and enhances cytotoxicity of conventional and novel agents

(2012) Merav Leiba et al.   BRITISH JOURNAL OF HAEMATOLOGY

Halofuginone Inhibits the Establishment and Progression of Melanoma Bone Metastases

(2012) P. Juarez et al.   CANCER RESEARCH

Targeting the ATF4 pathway in cancer therapy

(2012) Dean C Singleton et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase

(2012) Huihao Zhou et al.   NATURE

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

(2012) Tracy L Keller et al.   Nature Chemical Biology

Functional Specialization in Proline Biosynthesis of Melanoma

(2012) Jessica De Ingeniis et al.   PLoS One

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

The amino acid transporter SNAT2 mediates l-proline-induced differentiation of ES cells

(2011) Boon Siang Nicholas Tan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence

(2011) Patricia P Reis et al.   BMC CANCER

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Proline metabolism and cancer

(2011) James et al.   Frontiers in Bioscience-Landmark

Protein alterations associated with temozolomide resistance in subclones of human glioblastoma cell lines

(2011) Stella Sun et al.   JOURNAL OF NEURO-ONCOLOGY

Identification of PRDX4 and P4HA2 as Metastasis-Associated Proteins in Oral Cavity Squamous Cell Carcinoma by Comparative Tissue Proteomics of Microdissected Specimens Using iTRAQ Technology

(2011) Kai-Ping Chang et al.   JOURNAL OF PROTEOME RESEARCH

Halofuginone Has Anti-Proliferative Effects in Acute Promyelocytic Leukemia by Modulating the Transforming Growth Factor Beta Signaling Pathway

(2011) Lorena L. de Figueiredo-Pontes et al.   PLoS One

Control of embryonic stem cell metastability by l-proline catabolism

(2011) Laura Casalino et al.   Journal of Molecular Cell Biology

Proline Metabolism and Microenvironmental Stress

(2010) James M. Phang et al.   Annual Review of Nutrition

miR-23b* targets proline oxidase, a novel tumor suppressor protein in renal cancer

(2010) W Liu et al.   ONCOGENE

Inhibition of Pancreatic Stellate Cell Activation by Halofuginone Prevents Pancreatic Xenograft Tumor Development

(2010) Itai Spector et al.   PANCREAS

Halofuginone enhances the radiation sensitivity of human tumor cell lines

(2009) John A. Cook et al.   CANCER LETTERS

Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human Cancers

(2009) Y. Liu et al.   CANCER RESEARCH

The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells

(2009) Meagan M. Grudzien et al.   FERTILITY AND STERILITY

Defining Macropinocytosis

(2009) Markus C. Kerr et al.   TRAFFIC

Prolidase-dependent regulation of collagen biosynthesis

(2008) A. Surazynski et al.   AMINO ACIDS

Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

(2008) Sean J. Morrison et al.   CELL