A Novel Function for KLF4 in Modulating the De-Differentiation of EpCAM−/CD133− nonStem Cells into EpCAM+/CD133+ Liver Cancer Stem Cells in HCC Cell Line HuH7
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Novel Function for KLF4 in Modulating the De-Differentiation of EpCAM−/CD133− nonStem Cells into EpCAM+/CD133+ Liver Cancer Stem Cells in HCC Cell Line HuH7
Authors
Keywords
-
Journal
Cells
Volume 9, Issue 5, Pages 1198
Publisher
MDPI AG
Online
2020-05-12
DOI
10.3390/cells9051198
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Intratumoral heterogeneity and clonal evolution in liver cancer
- (2020) Bojan Losic et al. Nature Communications
- Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
- (2019) Eunsun Kim et al. Nature Communications
- Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance
- (2019) Maria Laura De Angelis et al. Frontiers in Oncology
- Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas
- (2019) Xiaofan Ding et al. GASTROENTEROLOGY
- Activation of EGFR‐KLF4 positive feedback loop results in acquired resistance to sorafenib in hepatocellular carcinoma
- (2019) Lijun Pang et al. MOLECULAR CARCINOGENESIS
- E-cadherin is required for metastasis in multiple models of breast cancer
- (2019) Veena Padmanaban et al. NATURE
- A global view of hepatocellular carcinoma: trends, risk, prevention and management
- (2019) Ju Dong Yang et al. Nature Reviews Gastroenterology & Hepatology
- Krüppel‐like factor 4 regulates stemness and mesenchymal properties of colorectal cancer stem cells through the TGF‐β1/Smad/snail pathway
- (2019) Zhengwei Leng et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- KLF4 functions as an oncogene in promoting cancer stem cell-like characteristics in osteosarcoma cells
- (2018) Xiao-tian Qi et al. ACTA PHARMACOLOGICA SINICA
- Krüppel-like factor 4 (KLF4): What we currently know
- (2017) Amr M. Ghaleb et al. GENE
- Establishment of Hepatocellular Cancer Induced Pluripotent Stem Cells Using a Reprogramming Technique
- (2017) Han Joon Kim et al. Gut and Liver
- Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma
- (2017) Ao Huang et al. JOURNAL OF HEPATOLOGY
- KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis
- (2017) Meera Murgai et al. NATURE MEDICINE
- Loss of KLF4 and consequential downregulation of Smad7 exacerbate oncogenic TGF-β signaling in and promote progression of hepatocellular carcinoma
- (2017) H Sun et al. ONCOGENE
- Cancer stem cells: The root of tumor recurrence and metastases
- (2017) Claudia Peitzsch et al. SEMINARS IN CANCER BIOLOGY
- Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015
- (2017) et al. JAMA Oncology
- Effect of adipocyte-secreted factors on EpCAM+/CD133+ hepatic stem cell population
- (2016) Zeynep Firtina Karagonlar et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Elevated hepatocyte growth factor expression as an autocrine c-Met activation mechanism in acquired resistance to sorafenib in hepatocellular carcinoma cells
- (2016) Zeynep Firtina Karagonlar et al. CANCER SCIENCE
- Beyond a tumor suppressor: Soluble E-cadherin promotes the progression of cancer
- (2016) Qi-Ping Hu et al. INTERNATIONAL JOURNAL OF CANCER
- EpCAM and the biology of hepatic stem/progenitor cells
- (2015) Laurent Dollé et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Pathogenesis and Prognosis of Hepatocellular Carcinoma at the Cellular and Molecular Levels
- (2015) Olivier Govaere et al. Clinics in Liver Disease
- Heterogeneity of hepatocellular carcinoma contributes to cancer progression
- (2015) Kuo-Shyang Jeng et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
- (2015) Alexandra Van Keymeulen et al. NATURE
- Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy
- (2015) Carolina Vicente-Dueñas et al. SEMINARS IN CANCER BIOLOGY
- High Cytoplasmic Expression of Krüppel-like Factor 4 Is an Independent Prognostic Factor of Better Survival in Hepatocellular Carcinoma
- (2014) Hui-Ting Hsu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Prognostic Significance of E-Cadherin Expression in Hepatocellular Carcinoma: A Meta-Analysis
- (2014) Jiang Chen et al. PLoS One
- Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells
- (2014) Ying-Chu Lin et al. Stem Cell Research & Therapy
- Function of oncogenes in cancer development: a changing paradigm
- (2013) Carolina Vicente-Dueñas et al. EMBO JOURNAL
- Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug
- (2013) Chun Sun et al. MEDICAL ONCOLOGY
- Cancer stem cells: The challenges ahead
- (2013) Jan Paul Medema NATURE CELL BIOLOGY
- Correction: Klf4 Is a Transcriptional Regulator of Genes Critical for EMT, Including Jnk1 (Mapk8)
- (2013) Neha Tiwari et al. PLoS One
- Cellular reprogramming and hepatocellular carcinoma development
- (2013) Yun-Wen Zheng WORLD JOURNAL OF GASTROENTEROLOGY
- The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma
- (2013) XIN YIN et al. Oncology Letters
- E-cadherin's dark side: Possible role in tumor progression
- (2012) Fausto J. Rodriguez et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Understanding cancer stem cell heterogeneity and plasticity
- (2012) Dean G Tang CELL RESEARCH
- Dysregulated Krüppel-Like Factor 4 and Vitamin D Receptor Signaling Contribute to Progression of Hepatocellular Carcinoma
- (2012) Qi Li et al. GASTROENTEROLOGY
- CD133+EpCAM+ Phenotype Possesses More Characteristics of Tumor Initiating Cells in Hepatocellular Carcinoma Huh7 Cells
- (2012) Yi Chen et al. International Journal of Biological Sciences
- The developing cancer stem-cell model: clinical challenges and opportunities
- (2012) Louis Vermeulen et al. LANCET ONCOLOGY
- Regulation of Stem Cell Plasticity: Mechanisms and Relevance to Tissue Biology and Cancer
- (2012) Robert Strauss et al. MOLECULAR THERAPY
- A restricted cell population propagates glioblastoma growth after chemotherapy
- (2012) Jian Chen et al. NATURE
- Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation
- (2012) S M Kumar et al. ONCOGENE
- Krüppel-Like Factor 4, a Tumor Suppressor in Hepatocellular Carcinoma Cells Reverts Epithelial Mesenchymal Transition by Suppressing Slug Expression
- (2012) Ze-Shiang Lin et al. PLoS One
- iPSCs from cancer cells: challenges and opportunities
- (2012) Verónica Ramos-Mejia et al. TRENDS IN MOLECULAR MEDICINE
- Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy
- (2011) Pinzhu Huang et al. CLINICAL BIOCHEMISTRY
- In vitro generation of human cells with cancer stem cell properties
- (2011) Paola Scaffidi et al. NATURE CELL BIOLOGY
- Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion
- (2011) F Yu et al. ONCOGENE
- Generation of iPSCs from cultured human malignant cells
- (2010) J. E. Carette et al. BLOOD
- Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity
- (2010) A. Sottoriva et al. CANCER RESEARCH
- Krüppel-like Factor 4 Inhibits Epithelial-to-Mesenchymal Transition through Regulation of E-cadherin Gene Expression
- (2010) Jennifer L. Yori et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cancer stem cells: Invitation to a second round
- (2010) Peter Dirks NATURE
- Cancer Stem Cells and Aneuploid Populations within Developing Tumors Are the Major Determinants of Tumor Dormancy
- (2009) A. P. Kusumbe et al. CANCER RESEARCH
- Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver
- (2009) M. Okabe et al. DEVELOPMENT
- EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma
- (2009) Benoit Terris et al. JOURNAL OF HEPATOLOGY
- The promises and perils of p53
- (2009) Valery Krizhanovsky et al. NATURE
- Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
- (2009) Jochen Utikal et al. NATURE
- Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation
- (2009) E. P. Papapetrou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Defined factors induce reprogramming of gastrointestinal cancer cells
- (2009) N. Miyoshi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure and Biochemistry of Cadherins and Catenins
- (2009) L. Shapiro et al. Cold Spring Harbor Perspectives in Biology
- EpCAM and -Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma
- (2008) T. Yamashita et al. CANCER RESEARCH
- EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features
- (2008) Taro Yamashita et al. GASTROENTEROLOGY
- Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
- (2008) X. Li et al. JNCI-Journal of the National Cancer Institute
- An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
- (2008) Ittai Ben-Porath et al. NATURE GENETICS
- Oct-4 Expression Maintained Cancer Stem-Like Properties in Lung Cancer-Derived CD133-Positive Cells
- (2008) Yu-Chih Chen et al. PLoS One
- EpCAM expression in normal, non-pathological tissues
- (2007) Eva Schmelzer Frontiers in Bioscience-Landmark
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation