Hakin-1, a New Specific Small-Molecule Inhibitor for the E3 Ubiquitin-Ligase Hakai, Inhibits Carcinoma Growth and Progression

Heat Shock Protein 90 Chaperone Regulates the E3 Ubiquitin-Ligase Hakai Protein Stability

(2020) Díaz-Díaz et al.   Cancers

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface

(2018) Maggie K. S. Tang et al.   Nature Communications

Hakai overexpression effectively induces tumour progression and metastasis in vivo

(2018) Raquel Castosa et al.   Scientific Reports

Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation

(2018) Min Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI

(2018) Chien-Hui Weng et al.   ONCOGENE

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

Proteomic Analysis of the E3 Ubiquitin-Ligase Hakai Highlights a Role in Plasticity of the Cytoskeleton Dynamics and in the Proteasome System

(2017) Andrea Díaz-Díaz et al.   JOURNAL OF PROTEOME RESEARCH

EMT: Present and future in clinical oncology

(2017) Patricia G. Santamaria et al.   Molecular Oncology

Cell plasticity in epithelial homeostasis and tumorigenesis

(2017) Julia Varga et al.   NATURE CELL BIOLOGY

Dub3 inhibition suppresses breast cancer invasion and metastasis by promoting Snail1 degradation

(2017) Yadi Wu et al.   Nature Communications

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Drugging the undruggables: exploring the ubiquitin system for drug development

(2016) Xiaodong Huang et al.   CELL RESEARCH

Epithelial–mesenchymal transition: a new target in anticancer drug discovery

(2016) Fabrizio Marcucci et al.   NATURE REVIEWS DRUG DISCOVERY

F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check

(2016) Víctor M. Díaz et al.   SEMINARS IN CANCER BIOLOGY

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

(2016) Asoka Banno et al.   Oncotarget

Clinical implications of epithelial cell plasticity in cancer progression

(2015) Luis A. Aparicio et al.   CANCER LETTERS

Dysregulation of ubiquitin ligases in cancer

(2015) Jianfei Qi et al.   DRUG RESISTANCE UPDATES

Targeting ubiquitination for cancer therapies

(2015) John Kenneth Morrow et al.   Future Medicinal Chemistry

Cell Regulation by Phosphotyrosine-Targeted Ubiquitin Ligases

(2015) Jonathan A. Cooper et al.   MOLECULAR AND CELLULAR BIOLOGY

Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities

(2015) Vivien Landré et al.   Oncotarget

Phase 1 study of weekly dosing with the investigational oral proteasome inhibitor ixazomib in relapsed/refractory multiple myeloma

(2014) S. K. Kumar et al.   BLOOD

Dimeric Switch of Hakai-truncated Monomers during Substrate Recognition

(2014) Manjeet Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALFA: Automatic Ligand Flexibility Assignment

(2014) Javier Klett et al.   Journal of Chemical Information and Modeling

Emerging therapies targeting the ubiquitin proteasome system in cancer

(2014) Nathaniel M. Weathington et al.   JOURNAL OF CLINICAL INVESTIGATION

Nutlin-3 inhibits epithelial–mesenchymal transition by interfering with canonical transforming growth factor-β1-Smad-Snail/Slug axis

(2013) Yeping Wu et al.   CANCER LETTERS

Posttranscriptional regulation by RNA-binding proteins during epithelial-to-mesenchymal transition

(2013) Luis A. Aparicio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

From Bortezomib to other Inhibitors of the Proteasome and Beyond

(2013) Daniela Buac et al.   CURRENT PHARMACEUTICAL DESIGN

Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies

(2013) Lindsey N. Micel et al.   JOURNAL OF CLINICAL ONCOLOGY

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Biological influence of Hakai in cancer: a 10-year review

(2012) Luis A. Aparicio et al.   CANCER AND METASTASIS REVIEWS

Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin

(2012) Manjeet Mukherjee et al.   EMBO JOURNAL

CRDOCK: An Ultrafast Multipurpose Protein–Ligand Docking Tool

(2012) Álvaro Cortés Cabrera et al.   Journal of Chemical Information and Modeling

A consistent description of HYdrogen bond and DEhydration energies in protein–ligand complexes: methods behind the HYDE scoring function

(2012) Nadine Schneider et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

miR-203 Regulates Cell Proliferation through Its Influence on Hakai Expression

(2012) Vanessa Abella et al.   PLoS One

Hakai reduces cell-substratum adhesion and increases epithelial cell invasion

(2011) Teresa Rodríguez-Rigueiro et al.   BMC CANCER

Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis

(2011) Wei-Jie Zhou et al.   CELL RESEARCH

Carfilzomib: a novel second-generation proteasome inhibitor

(2011) Meaghan L Khan et al.   Future Oncology

VSDMIP 1.5: an automated structure- and ligand-based virtual screening platform with a PyMOL graphical user interface

(2011) Álvaro Cortés Cabrera et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Rack1 promotes epithelial cell–cell adhesion by regulating E-cadherin endocytosis

(2011) G Swaminathan et al.   ONCOGENE

A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues

(2011) Teresa Rodríguez-Rigueiro et al.   PROTEOMICS

Ubiquitin: Same Molecule, Different Degradation Pathways

(2010) Michael J. Clague et al.   CELL

Hacking RNA: Hakai promotes tumorigenesis by enhancing the RNA-binding function of PSF

(2010) Angélica Figueroa et al.   CELL CYCLE

High-quality genomic DNA extraction from formalin-fixed and paraffin-embedded samples deparaffinized using mineral oil

(2009) Jianghai Lin et al.   ANALYTICAL BIOCHEMISTRY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

A phase II evaluation of bortezomib in the treatment of recurrent platinum-sensitive ovarian or primary peritoneal cancer: A Gynecologic Oncology Group study

(2009) Carol Aghajanian et al.   GYNECOLOGIC ONCOLOGY

Novel Roles of Hakai in Cell Proliferation and Oncogenesis

(2009) Angélica Figueroa et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

(2009) Brenda A. Schulman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phase II study of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma: CALGB 90207

(2008) J. E. Rosenberg et al.   ANNALS OF ONCOLOGY

Quantification of green fluorescent protein by in vivo imaging, PCR, and flow cytometry: Comparison of transgenic strains and relevance for fetal cell microchimerism

(2008) Yutaka Fujiki et al.   CYTOMETRY PART A

VSDMIP: virtual screening data management on an integrated platform

(2008) Rubén Gil-Redondo et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN