Article
Oncology
Yuli Wang, Shuang Shi, Yunshan Wang, Xuhua Zhang, Xiaoyan Liu, Juan Li, Peilong Li, Lutao Du, Chuanxin Wang
Summary: The study revealed that miR-223-3p is overexpressed in breast cancer, associated with poor prognosis, promotes cell migration and invasion, and exerts its oncogenic role by targeting the tumor suppressor gene FBXW7 to promote invasion and metastasis in breast cancer.
Article
Oncology
Andreia S. Margarido, Rebeca Uceda-Castro, Kerstin Hahn, Roebi de Bruijn, Lennart Kester, Ingrid Hofland, Jeroen Lohuis, Danielle Seinstra, Annegien Broeks, Jos Jonkers, Marike L. D. Broekman, Pieter Wesseling, Claire Vennin, Miguel Vizoso, Jacco van Rheenen
Summary: The study demonstrates that breast cancer brain metastasis cells undergo epithelial-to-mesenchymal transition (EMT) when infiltrating the brain parenchyma, and removing these infiltrated tumor cells can improve surgical efficacy, providing new avenues for patient treatment.
Article
Biotechnology & Applied Microbiology
HuiJuan Liu, Hui Ye, Xinzheng Li
Summary: miR-138 plays a crucial role in breast cancer cells by targeting SEMA4C and affecting the expression levels of E-cad and N-cad. It can modulate the vitality and invasion of breast cancer cells.
Article
Reproductive Biology
Qiao Ping Xu, Kui Deng, Zhen Zhang, Hongkai Shang
Summary: Ovarian cancer is a growing global disease, and there is an urgent need for chemotherapy and targeted therapy. SLFN5 plays an important role in malignancy, but its specific function in ovarian cancer cells is still unclear. This study suggests that SLFN5 expression is related to the progression and malignancy of ovarian cancer, and its silencing has a significant inhibitory effect on the invasion and metastasis ability of ovarian cancer cells. Therefore, SLFN5 may serve as a potential target for future drug development in the treatment of ovarian cancer.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Physics, Multidisciplinary
Kijung Kim, Jinseung Choung, Ung Hyun Ko, Ara Jung, Wonho Choe, Jennifer H. Shin, Bomi Gweon
Summary: Atmospheric pressure plasma (APP) has emerged as a potent tool for cancer therapy due to its various anti-cancer effects, including altering cancer cell morphology, suppressing migratory activity, and reducing invasiveness. By down-regulating markers associated with epithelial to mesenchymal transition (EMT), APP treatment may have the potential to suppress cancer metastasis.
FRONTIERS IN PHYSICS
(2021)
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Integrative & Complementary Medicine
Yih-Shou Hsieh, Shu-Chen Chu, Shih-Chien Huang, Shao-Hsuan Kao, Meng-Shuan Lin, Pei-Ni Chen
Summary: The research showed that gossypol inhibited the invasion and migration of human cervical cancer cells by targeting the FAK signaling pathway and reversing TGF-beta 1-induced EMT.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Qiaosi Tang, Ashley Lento, Kensuke Suzuki, Gizem Efe, Tatiana Karakasheva, Apple Long, Veronique Giroux, Mirazul Islam, E. Paul Wileyto, Andres J. Klein-Szanto, Hiroshi Nakagawa, Adam Bass, Anil K. Rustgi
Summary: The study reveals that TP53 mutation is the most common in ESCC, while Rab11-FIP1 gene is significantly downregulated in mutant p53 tumor cells. Genetic knockdown of Rab11-FIP1 results in increased organoid size and promotes tumor cell invasion through mutant p53.
Article
Cell Biology
Yan Wang, Tianfu Dong, Peishun Wang, Shuqin Li, Geng Wu, Jun Zhou, Zhiqi Wang
Summary: This study investigated the role of lincRNA LINC00922 in breast cancer development, and found that it promotes tumor progression by promoting NKD2 methylation.
CELLULAR SIGNALLING
(2021)
Article
Biotechnology & Applied Microbiology
Aitao Sun, JinBo Li, Weijing Kong, Xiaodong Jiang
Summary: This study investigates the expression and underlying mechanisms of the immunoglobulin superfamily containing leucine-rich repeat (ISLR) in gastric cancer (GC). The findings suggest that ISLR is overexpressed in GC tumor tissues and cells and is associated with lymph node metastasis, tumor size, and clinical stage. Additionally, ISLR regulates the epithelial-mesenchymal transition (EMT) signaling pathway and affects cell viability, proliferation, migration, and invasion in GC cells. These results provide new evidence for the role of ISLR in GC progression.
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Narges Maleki, Negar Yavari, Maryam Ebrahimi, Ahmad Faisal Faiz, Roya Khosh Ravesh, Aysan Sharbati, Mohammad Panji, Keivan Lorian, Abdollah Gravand, Mojtaba Abbasi, Omid Abazari, Mehdi Shafiee Mehr, Yasin Eskandari
Summary: Silibinin exhibits strong inhibitory effects on ovarian cancer by suppressing cell viability, migration, and invasion, and promoting apoptosis. It also reverses epithelial-mesenchymal transition mechanism and ameliorates tumor growth.
Article
Biochemistry & Molecular Biology
Samuel A. Vilchez Mercedes, Federico Bocci, Mona Ahmed, Ian Eder, Ninghao Zhu, Herbert Levine, Jose N. Onuchic, Mohit Kumar Jolly, Pak Kin Wong
Summary: In this study, the researchers used a combination of immunocytochemistry, single cell biosensors, and computational modeling to show that the transcription factor Nrf2 functions as a phenotypic stability factor for hybrid epithelial/mesenchymal cells during collective cancer migration. They also demonstrated that Nrf2 and EMT signaling are spatially coordinated near the leading edge, and that the Nrf2-EMT-Notch network enhances the expression of certain genes associated with the formation of leader cells and protruding tips.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Liang Lyu, Haiyan Li, Kefeng Lu, Shu Jiang, Huihui Li
Summary: This study demonstrates that FRAX486, a potent PAK2 inhibitor, suppresses TNBC metastasis by blocking autophagy. Mechanistically, FRAX486 inhibits autophagy in TNBC cells by targeting PAK2, resulting in the ubiquitination and proteasomal degradation of STX17, which mediates autophagosome-lysosome fusion. Inhibition of autophagy by FRAX486 leads to upregulation of E-cadherin and consequently suppresses TNBC cell migration and metastasis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Shirley Jusino, Yainyrette Rivera-Rivera, Camille Chardon-Colon, Armando J. Ruiz-Justiz, Jaleisha Velez-Velazquez, Angel Isidro, Melanie E. Cruz-Robles, Margarita Bonilla-Claudio, Guillermo N. Armaiz-Pena, Harold Saavedra
Summary: The study demonstrates that overexpression of E2F3 and Shugoshin-1 in breast cancer promotes tumor metastasis, while their silencing suppresses cell invasion and migration. Additionally, E2F3 and Shugoshin-1 regulate the expression of genes associated with epithelial-to-mesenchymal transition.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
A. W. Mao, H. Barck, J. Young, A. Paley, J-H Mao, H. Chang
Summary: The study identified a 15-microbe prognostic signature for breast cancer patients by analyzing TCGA BC microbiome data, which showed good predictive efficacy in patient survival and progression-free survival. The microbial abundance prognostic scoring model was found to be an independent prognostic factor for overall survival and progression-free survival, outperforming previously published gene signatures.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Ines Guix, Qi Liu, Miquel Angel Pujana, Patrick Ha, Josep Piulats, Isabel Linares, Ferran Guedea, Jian-Hua Mao, Ann Lazar, Jocelyn Chapman, Sue S. Yom, Alan Ashworth, Mary Helen Barcellos-Hoff
Summary: This study confirms the anticorrelation between TGF beta signaling and alt-EJ gene expression signatures, as well as their predictive value for response to genotoxic therapy. The findings validate the role of TGF beta as a key mediator of DNA repair and demonstrate the feasibility of using gene expression to assess TGF beta signaling and DNA repair.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jianhui Bin, Lieselotte Obst-Huebl, Jian-Hua Mao, Kei Nakamura, Laura D. Geulig, Hang Chang, Qing Ji, Li He, Jared De Chant, Zachary Kober, Anthony J. Gonsalves, Stepan Bulanov, Susan E. Celniker, Carl B. Schroeder, Cameron G. R. Geddes, Eric Esarey, Blake A. Simmons, Thomas Schenkel, Eleanor A. Blakely, Sven Steinke, Antoine M. Snijders
Summary: Radiotherapy is the standard treatment for over 50% of cancer patients, and the use of FLASH-RT may provide additional benefits. Researchers have developed an experimental platform that delivers ultra-high dose rates of proton pulses to biological samples. Preliminary findings show that normal cells have higher survival rates compared to tumor cells at high dose rates.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Roberto Corchado-Cobos, Natalia Garcia-Sancha, Marina Mendiburu-Elicabe, Aurora Gomez-Vecino, Alejandro Jimenez-Navas, Manuel Jesus Perez-Baena, Marina Holgado-Madruga, Jian-Hua Mao, Javier Canueto, Sonia Castillo-Lluva, Jesus Perez-Losada
Summary: Metabolic changes in tumor cells and their interactions with stromal cells play a crucial role in tumor growth and progression. Understanding these metabolic changes can help identify new treatment strategies. Breast cancer serves as a useful example to illustrate the metabolic alterations in cancer.
Article
Oncology
Hang Chang, Xu Yang, Jade Moore, Xiao-Ping Liu, Kuang-Yu Jen, Antoine M. Snijders, Lin Ma, William Chou, Roberto Corchado-Cobos, Natalia Garcia-Sancha, Marina Mendiburu-Elicabe, Jesus Perez-Losada, Mary Helen Barcellos-Hoff, Jian-Hua Mao
Summary: Mouse models of cancer play an important role in investigating cancer biology. This study developed a machine learning approach to identify cellular morphometric biomarkers from digital images of mammary tumors, and demonstrated their significance in predicting survival and metastasis. The findings suggest that this approach can provide unbiased biological stratification to guide patient care.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Dafa Ding, Huijuan Yong, Na You, Wei Lu, Xu Yang, Xiaolong Ye, Yayun Wang, Tingting Cai, Xiaoling Zheng, Hui Chen, Bota Cui, Faming Zhang, Xingyin Liu, Jian-Hua Mao, Yibing Lu, Hang Chang
Summary: This study found that fecal microbiota transplantation (FMT) therapy can improve symptoms and metabolic parameters in patients with type 2 diabetes mellitus (T2DM). Out of 17 patients, 11 showed significant improvement. Additionally, the presence of certain microbial species can predict the clinical response to FMT treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Binbin Yuan, Chengfei Jiang, Lingyan Chen, Lihui Wen, Jinlong Cui, Min Chen, Shu Zhang, Lin Zhou, Yimeng Cai, Jian-Hua Mao, Xiaoping Zou, Bo Hang, Pin Wang
Summary: Through evaluating the DNA repair gene signature in gastric cancer patients, this study found that patients with high scores had better therapeutic outcomes with immune checkpoint blockade therapy. These high DRGS score patients exhibited higher levels of anti-tumor lymphocyte infiltration, tumor mutation burden, PD-L1 expression, and longer overall survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Xiao-Ping Liu, Xiaoqing Jin, Saman Seyed Ahmadian, Xu Yang, Su-Fang Tian, Yu-Xiang Cai, Kuldeep Chawla, Antoine M. Snijders, Yankai Xia, Paul J. van Diest, William A. Weiss, Jian-Hua Mao, Zhi-Qiang Li, Hannes Vogel, Hang Chang
Summary: By developing and validating cellular morphometric subtypes (CMS), personalized diagnosis and therapy for LGG patients can be achieved. These subtypes can predict patient prognosis and treatment response based on molecular alterations and immune microenvironment, and also have translational impact on glioblastoma.
Article
Veterinary Sciences
Libette J. Roman, Antoine M. Snijders, Hang Chang, Jian-Hua Mao, Kristina J. A. Jones, Gregory W. Lawson
Summary: This study examines the effect of different barrier practices on the fecal microbiome of breeding C57Bl/6J mice. The results show that differences in barrier husbandry practices can affect fecal microbiome divergence in both the parental and filial generations of different breeding colonies.
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2023)
Article
Environmental Sciences
Hui Yang, Xinzhi Wang, Pin Wang, Li He, Suzyann F. Schick, Peyton Jacob, Neal Benowitz, Lara A. Gundel, Chi Zhu, Yankai Xia, Jamie L. Inman, Hang Chang, Antoine M. Snijders, Jian-Hua Mao, Bo Hang
Summary: Increasing evidence suggests that thirdhand smoke (THS) exposure has adverse health effects and may increase cancer risk. This study used the Collaborative Cross (CC) mouse population-based model system to assess the effects of THS exposure on cancer risk and found an increased incidence and burden of tumors in THS-treated mice. Lung and liver tissues were particularly susceptible to tumorigenesis after THS exposure. The study also highlighted the importance of host genetic background in individual susceptibility to THS-induced tumorigenesis and emphasized the need to consider genetic factors when determining cancer risk in humans exposed to THS.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Substance Abuse
Georg E. Matt, Lydia Greiner, Rachael A. Record, Heather Wipfli, Jamie Long, Nathan G. Dodder, Eunha Hoh, Nicolas Lopez Galvez, Thomas E. Novotny, Penelope J. E. Quintana, Hugo Destaillats, Xiaochen Tang, Antoine M. Snijders, Jian-Hua Mao, Bo Hang, Suzaynn Schick, Peyton Jacob, Prue Talbot, E. Melinda Mahabee-Gittens, Ashley L. Merianos, Thomas F. Northrup, Lara Gundel, Neal L. Benowitz
Summary: Since the 1970s, policies prohibiting smoking indoors have saved numerous lives and reduced healthcare expenditure. However, these policies do not fully protect the public from the long-lasting toxic residues of tobacco smoke, known as thirdhand smoke. This article discusses the differences between secondhand and thirdhand smoke exposure and proposes four policy considerations to better protect the public and remediate thirdhand smoke.
Article
Endocrinology & Metabolism
Lijuan Chen, Lin Guo, Susu Feng, Congcong Wang, Zhicheng Cui, Sijing Wang, Qingmiao Lu, Hang Chang, Bo Hang, Antoine M. Snijders, Jian-Hua Mao, Yibing Lu, Dafa Ding
Summary: This study confirms the effectiveness of FMT in treating patients with T2DM and demonstrates its positive impact on gut microbiome, serum metabolites, intestinal epithelial barrier, inflammation, and circulating immune cells.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Cell Biology
Aurora Gomez-Vecino, Roberto Corchado-Cobos, Adrian Blanco-Gomez, Natalia Garcia-Sancha, Sonia Castillo-Lluva, Ana Martin-Garcia, Marina Mendiburu-Elicabe, Carlos Prieto, Sara Ruiz-Pinto, Guillermo Pita, Alejandro Velasco-Ruiz, Carmen Patino-Alonso, Purificacion Galindo-Villardon, Maria Linarejos Vera-Pedrosa, Jose Jalife, Jian-Hua Mao, Guillermo Macias de Plasencia, Andres Castellanos-Martin, Maria del Mar Saez-Freire, Susana Fraile-Martin, Telmo Rodrigues-Teixeira, Carmen Garcia-Macias, Julie Milena Galvis-Jimenez, Asuncion Garcia-Sanchez, Maria Isidoro-Garcia, Manuel Fuentes, Maria Begona Garcia-Cenador, Francisco Javier Garcia-Criado, Juan Luis Garcia-Hernandez, Maria Angeles Hernandez-Garcia, Juan Jesus Cruz-Hernandez, Cesar Augusto Rodriguez-Sanchez, Alejandro Martin Garcia-Sancho, Estefania Perez-Lopez, Antonio Perez-Martinez, Federico Gutierrez-Larraya, Antonio J. Carton, Jose Angel Garcia-Saenz, Ana Patino-Garcia, Miguel Martin, Teresa Alonso-Gordoa, Christof Vulsteke, Lieselot Croes, Sigrid Hatse, Thomas Van Brussel, Diether Lambrechts, Hans Wildiers, Hang Chang, Marina Holgado-Madruga, Anna Gonzalez-Neira, Pedro L. Sanchez, Jesu Perez Losada
Summary: Cardiotoxicity due to anthracyclines (CDA) affects cancer patients, and identifying individuals at risk is challenging. In this study, the authors investigated intermediate molecular phenotypes (IMPs) associated with myocardial damage to determine CDA susceptibility. By analyzing a mouse cohort treated with doxorubicin and docetaxel, they identified genetic markers linked to IMPs and CDA. These markers were also found to be associated with CDA in cancer patients, highlighting their potential as predictive factors. Additionally, genetic risk scores were generated using machine-learning regression to personalize patient management.
Article
Oncology
Xuanyu Mao, Yimeng Cai, Sarah Long, Jesus Perez-Losada, Jian-Hua Mao, Hang Chang
Summary: Increased mitotic activity is associated with the genesis and aggressiveness of many cancers. The mitotic network activity index (MNAI) constructed based on a 54-gene mitotic apparatus network has been evaluated as a potential prognostic biomarker in a pan-cancer study. The study confirmed the significant association of MNAI with overall survival, progression-free survival, and other prognostic endpoints in multiple cancer types, and also revealed its association with genetic instability and treatment response.
FRONTIERS IN ONCOLOGY
(2023)
Article
Microbiology
Kenneth H. H. Wan, Soo Park, Benjamin W. W. Booth, Ella C. C. Brydon, Joanne Eichenberger, Jamie L. L. Inman, Jian-Hua Mao, Antoine M. M. Snijders, Susan E. E. Celniker
Summary: Microbacterium sp. BDGP8 is a facultative anaerobic gram-positive bacterium belonging to the family Microbacteriaceae. Its complete genome consists of a single circular chromosome of 3,293,567 bp with a G + C content of 69.84% and two plasmids of 49,365 bp and 32,884 bp.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)