EGCG Mediated Targeting of Deregulated Signaling Pathways and Non-Coding RNAs in Different Cancers: Focus on JAK/STAT, Wnt/β-Catenin, TGF/SMAD, NOTCH, SHH/GLI, and TRAIL Mediated Signaling Pathways

Diet-Derived Gallated Catechins Prevent TGF-β-Mediated Epithelial-Mesenchymal Transition, Cell Migration and Vasculogenic Mimicry in Chemosensitive ES-2 Ovarian Cancer Cells

(2020) Audrey-Ann Sicard et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Green tea-induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase-3 suppresses prostate cancer progression through histone-modifying enzymes

(2019) Gauri Deb et al.   MOLECULAR CARCINOGENESIS

Anti-proliferative and anti-apoptotic potential effects of epigallocatechin-3-gallate and/or metformin on hepatocellular carcinoma cells: in vitro study

(2019) Dina Sabry et al.   MOLECULAR BIOLOGY REPORTS

(−)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway

(2019) Xiaoqin La et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Modulation of Myb‐induced NF‐kB ‐STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors

(2019) Miao Tian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pharmacokinetic, toxicokinetic, and bioavailability studies of epigallocatechin-3-gallate loaded solid lipid nanoparticle in rat model

(2019) Nithya Ramesh et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Hydrophobic Interactions Drive Binding between Vascular Endothelial Growth Factor-A (VEGFA) and Polyphenolic Inhibitors

(2019) Natalia Perez-Moral et al.   MOLECULES

Combination of Epigallocatechin-3-gallate and Silibinin: A Novel Approach for Targeting Both Tumor and Endothelial Cells

(2019) Somaye Mirzaaghaei et al.   ACS Omega

Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine

(2019) Wei et al.   Nutrients

From tea to treatment; epigallocatechin gallate and its potential involvement in minimizing the metabolic changes in cancer

(2019) Amanda L. Tauber et al.   NUTRITION RESEARCH

“Stealth and Fully-Laden” Drug Carriers: Self-Assembled Nanogels Encapsulated with Epigallocatechin Gallate and siRNA for Drug-Resistant Breast Cancer Therapy

(2018) Jie Ding et al.   ACS Applied Materials & Interfaces

Green tea extracts for the prevention of metachronous colorectal polyps among patients who underwent endoscopic removal of colorectal adenomas: A randomized clinical trial

(2018) Cheol Min Shin et al.   CLINICAL NUTRITION

Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review

(2018) Nadda Muhamad et al.   International Journal of Nanomedicine

SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition

(2018) Wanchun Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting of EGFR, VEGFR2, and Akt by Engineered Dual Drug Encapsulated Mesoporous Silica–Gold Nanoclusters Sensitizes Tamoxifen-Resistant Breast Cancer

(2018) B. N. Prashanth Kumar et al.   MOLECULAR PHARMACEUTICS

In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea

(2018) Koichi Saeki et al.   MOLECULES

(-)-Epigallocatechin-3-gallate induces cell apoptosis in chronic myeloid leukemia by regulating Bcr/Abl-mediated p38-MAPK/JNK and JAK2/STAT3/AKT signaling pathways

(2018) Xiang Xiao et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Main trends of immune effects triggered by nanomedicines in preclinical studies

(2018) Blanka Halamoda-Kenzaoui et al.   International Journal of Nanomedicine

Epigallocatechin-3-gallate inhibited cancer stem cell-like properties by targeting hsa-mir-485-5p/RXRα in lung cancer

(2018) Pan Jiang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

EGCG inhibits CSC-like properties through targeting miR-485/CD44 axis in A549-cisplatin resistant cells

(2018) Pan Jiang et al.   MOLECULAR CARCINOGENESIS

Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor that Inhibits PD-L1 Expression and Lung Tumor Growth

(2018) Anchalee Rawangkan et al.   MOLECULES

Epigallocatechin Gallate Preferentially Inhibits O6-Methylguanine DNA-Methyltransferase Expression in Glioblastoma Cells Rather than in Nontumor Glial Cells

(2018) Chao-Ran Xie et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Molecular Targets of Epigallocatechin—Gallate (EGCG): A Special Focus on Signal Transduction and Cancer

(2018) Aide Negri et al.   Nutrients

Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells

(2018) Kayla Lewis et al.   Cancers

The Toxicity of Nanoparticles Depends on Multiple Molecular and Physicochemical Mechanisms

(2017) Yue-Wern Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Down-regulation of histone deacetylase 4, −5 and −6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin

(2017) Yukiko Oya et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells

(2017) Veronika Borutinskaitė et al.   LEUKEMIA & LYMPHOMA

Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma

(2017) Yasmin M. Shaalan et al.   NATURAL PRODUCT RESEARCH

Epigallocatechin-3-gallate enhances differentiation of acute promyelocytic leukemia cells via inhibition of PML-RARα and HDAC1

(2017) Maliheh Moradzadeh et al.   PHYTOTHERAPY RESEARCH

Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity

(2017) Vikrant Borse et al.   Cell Death & Disease

Epigallocatechin gallate inhibits the growth of MDA-MB-231 breast cancer cells via inactivation of the β-catenin signaling pathway

(2017) On-Yu Hong et al.   Oncology Letters

(−)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway

(2017) Yue Chen et al.   Nutrients

Therapeutic Potential of Epigallocatechin Gallate Nanodelivery Systems

(2017) Andreia Granja et al.   Biomed Research International

Combination curcumin and (−)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway

(2017) G Jin et al.   Oncogenesis

Targeted nanoparticles encapsulating (−)-epigallocatechin-3-gallate for prostate cancer prevention and therapy

(2017) Vanna Sanna et al.   Scientific Reports

Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial

(2016) Hamed Samavat et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Phase I study of topical epigallocatechin-3-gallate (EGCG) in patients with breast cancer receiving adjuvant radiotherapy

(2016) Hanxi Zhao et al.   BRITISH JOURNAL OF RADIOLOGY

Epigallocatechin gallate sensitizes cisplatin-resistant oral cancer CAR cell apoptosis and autophagy through stimulating AKT/STAT3 pathway and suppressing multidrug resistance 1 signaling

(2016) Chien-Han Yuan et al.   ENVIRONMENTAL TOXICOLOGY

Biophysical characteristics of proteins and living cells exposed to the green tea polyphenol epigallocatechin-3-gallate (EGCg): review of recent advances from molecular mechanisms to nanomedicine and clinical trials

(2016) Beatrix Peter et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin

(2016) Yoo Seob Shin et al.   PHYTOMEDICINE

Anticancer activities of epigallocatechin-3-gallate against cholangiocarcinoma cells

(2016) Tae Won Kwak et al.   OncoTargets and Therapy

Effect of Tea Polyphenol Compounds on Anticancer Drugs in Terms of Anti-Tumor Activity, Toxicology, and Pharmacokinetics

(2016) Jianhua Cao et al.   Nutrients

NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells

(2016) Pan Jiang et al.   Oncotarget

Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer

(2016) Shusuke Toden et al.   Oncotarget

Activation of autophagic flux by epigallocatechin gallate mitigates TRAIL-induced tumor cell apoptosis via down-regulation of death receptors

(2016) Sung-Wook Kim et al.   Oncotarget

Improving the Anticancer Efficacy of Laminin Receptor-Specific Therapeutic Ruthenium Nanoparticles (RuBB-Loaded EGCG-RuNPs) via ROS-Dependent Apoptosis in SMMC-7721 Cells

(2015) Yanhui Zhou et al.   ACS Applied Materials & Interfaces

A derivative of epigallocatechin-3-gallate induces apoptosis via SHP-1-mediated suppression of BCR-ABL and STAT3 signalling in chronic myelogenous leukaemia

(2015) Ji Hoon Jung et al.   BRITISH JOURNAL OF PHARMACOLOGY

Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention

(2015) N. B. Kumar et al.   Cancer Prevention Research

Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus

(2015) A. K. Joe et al.   Cancer Prevention Research

Paclitaxel/Epigallocatechin gallate coloaded liposome: A synergistic delivery to control the invasiveness of MDA-MB-231 breast cancer cells

(2015) Satiesh Kumar Ramadass et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

miR-1275: A single microRNA that targets the three IGF2-mRNA-binding proteins hindering tumor growth in hepatocellular carcinoma

(2015) Injie Omar Fawzy et al.   FEBS LETTERS

The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial

(2015) Allison M. Dostal et al.   FOOD AND CHEMICAL TOXICOLOGY

Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection — synthesis, characterization and in vitro evaluation

(2015) Sudeshna Mukherjee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sequential release of epigallocatechin gallate and paclitaxel from PLGA-casein core/shell nanoparticles sensitizes drug-resistant breast cancer cells

(2015) Sreeja Narayanan et al.   Nanomedicine-Nanotechnology Biology and Medicine

(−)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human cervical cancer cells

(2015) MUNAWWAR ALI KHAN et al.   ONCOLOGY REPORTS

Epigallocatechin Gallate/Layered Double Hydroxide Nanohybrids: Preparation, Characterization, and In Vitro Anti-Tumor Study

(2015) Seyedeh Sara Shafiei et al.   PLoS One

A prospective phase II trial of EGCG in treatment of acute radiation-induced esophagitis for stage III lung cancer

(2015) Hanxi Zhao et al.   RADIOTHERAPY AND ONCOLOGY

Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

(2015) Malin Wickström et al.   Nature Communications

Epigallocatechin-3-gallate Sensitizes Human 786-O Renal Cell Carcinoma Cells to TRAIL-Induced Apoptosis

(2014) Ruojing Wei et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities

(2014) Mario Sechi et al.   International Journal of Nanomedicine

Genipin-Structured Peptide–Polysaccharide Nanoparticles with Significantly Improved Resistance to Harsh Gastrointestinal Environments and Their Potential for Oral Delivery of Polyphenols

(2014) Bing Hu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Excellent anti-proliferative and pro-apoptotic effects of (−)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo

(2014) Imtiaz A. Siddiqui et al.   Nanomedicine-Nanotechnology Biology and Medicine

Increased STAT1 Signaling in Endocrine-Resistant Breast Cancer

(2014) Rui Huang et al.   PLoS One

A phase I study of concurrent chemotherapy and thoracic radiotherapy with oral epigallocatechin-3-gallate protection in patients with locally advanced stage III non-small-cell lung cancer

(2014) Hanxi Zhao et al.   RADIOTHERAPY AND ONCOLOGY

Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells

(2014) Ming-Kung Yeh et al.   Drug Design Development and Therapy

TGF-β1-induced epithelial–mesenchymal transition and acetylation of Smad2 and Smad3 are negatively regulated by EGCG in Human A549 lung cancer cells

(2013) Hyeonseok Ko et al.   CANCER LETTERS

Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model

(2013) N. Khan et al.   CARCINOGENESIS

Epigallocatechin-3-gallate attenuates head and neck cancer stem cell traits through suppression of Notch pathway

(2013) Sang Hyuk Lee et al.   EUROPEAN JOURNAL OF CANCER

Anticancer activities of (−)-epigallocatechin-3-gallate encapsulated nanoliposomes in MCF7 breast cancer cells

(2013) Rita Castillo Cohen de Pace et al.   JOURNAL OF LIPOSOME RESEARCH

Sensitization of TRAIL-induced apoptosis in human hepatocellular carcinoma HepG2 cells by phytochemicals

(2013) Reem N. Abou El Naga et al.   LIFE SCIENCES

A new world of Polycombs: unexpected partnerships and emerging functions

(2013) Yuri B. Schwartz et al.   NATURE REVIEWS GENETICS

Quercetin and EGCG Exhibit Chemopreventive Effects in Cholangiocarcinoma Cells via Suppression of JAK/STAT Signaling Pathway

(2013) Laddawan Senggunprai et al.   PHYTOTHERAPY RESEARCH

Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling

(2013) Heiying Jin et al.   OncoTargets and Therapy

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1

(2012) Mayada Achour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gold nanoparticles as novel agents for cancer therapy

(2012) S Jain et al.   BRITISH JOURNAL OF RADIOLOGY

Phase 2 trial of daily, oral polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia

(2012) Tait D. Shanafelt et al.   CANCER

Effect of 2-Month Controlled Green Tea Intervention on Lipoprotein Cholesterol, Glucose, and Hormone Levels in Healthy Postmenopausal Women

(2012) A. H. Wu et al.   Cancer Prevention Research

Design of polymeric nanoparticles for biomedical delivery applications

(2012) Mahmoud Elsabahy et al.   CHEMICAL SOCIETY REVIEWS

Green tea polyphenols increase p53 transcriptional activity and acetylation by suppressing class�I histone deacetylases

(2012) Sanjay Gupta   INTERNATIONAL JOURNAL OF ONCOLOGY

EGCG Inhibits Transforming Growth Factor-β-Mediated Epithelial-to-Mesenchymal Transition via the Inhibition of Smad2 and Erk1/2 Signaling Pathways in Nonsmall Cell Lung Cancer Cells

(2012) Liang-Chih Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tea phenols in bulk and nanoparticle form modify DNA damage in human lymphocytes from colon cancer patients and healthy individuals treated in vitro with platinum-based chemotherapeutic drugs

(2012) Amal Alotaibi et al.   Nanomedicine

(-)-Epigallocatechin gallate inhibits the expression of indoleamine 2,3-dioxygenase in human colorectal cancer cells

(2012) KENGO OGAWA et al.   Oncology Letters

The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles

(2011) Dar-Shih Hsieh et al.   BIOMATERIALS

(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells

(2011) V. Nandakumar et al.   CARCINOGENESIS

Targeted Biocompatible Nanoparticles for the Delivery of (−)-Epigallocatechin 3-Gallate to Prostate Cancer Cells

(2011) Vanna Sanna et al.   JOURNAL OF MEDICINAL CHEMISTRY

SU5416 and EGCG Work Synergistically and Inhibit Angiogenic and Survival Factors and Induce Cell Cycle Arrest to Promote Apoptosis in Human Malignant Neuroblastoma SH-SY5Y and SK-N-BE2 Cells

(2011) Nishant Mohan et al.   NEUROCHEMICAL RESEARCH

(−)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells

(2010) Masahito Shimizu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

IKK  controls canonical TGF -SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells

(2010) M. Brandl et al.   JOURNAL OF CELL SCIENCE

Epigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemoprevention

(2010) Sandra Rocha et al.   Nanomedicine

MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways

(2010) X Rao et al.   ONCOGENE

Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols

(2009) Tatsiana G. Shutava et al.   ACS Nano

Tea Polyphenols Decrease Serum Levels of Prostate-Specific Antigen, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor in Prostate Cancer Patients and Inhibit Production of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor In vitro

(2009) J. McLarty et al.   Cancer Prevention Research

Introducing Nanochemoprevention as a Novel Approach for Cancer Control: Proof of Principle with Green Tea Polyphenol Epigallocatechin-3-Gallate

(2009) I. A. Siddiqui et al.   CANCER RESEARCH

(-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis

(2009) Yohei Shirakami et al.   CANCER SCIENCE

The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival

(2009) S. Balasubramanian et al.   CARCINOGENESIS

Indoleamine 2,3-Dioxygenase, an Immunomodulatory Protein, Is Suppressed by (−)-Epigallocatechin-3-gallate via Blocking of γ-Interferon-Induced JAK-PKC-δ-STAT1 Signaling in Human Oral Cancer Cells

(2009) Chieh-Wen Cheng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate

(2008) M J Scandlyn et al.   BRITISH JOURNAL OF CANCER

Therapeutic Nanoparticles for Drug Delivery in Cancer

(2008) K. Cho et al.   CLINICAL CANCER RESEARCH

Epigalocatechin-3-gallate (EGCG) downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant glioma

(2008) M.D. Siegelin et al.   NEUROSCIENCE LETTERS

Multifunctional nanoparticles – properties and prospects for their use in human medicine

(2008) Nuria Sanvicens et al.   TRENDS IN BIOTECHNOLOGY