Mechanotransduction in Wound Healing and Fibrosis

Targeting GPCR Signaling for Idiopathic Pulmonary Fibrosis Therapies

(2020) Andrew J. Haak et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Focus on “Eye on” Channels in Pulmonary Fibrosis

(2019) Rachel G. Scheraga et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Controlled Delivery of a Focal Adhesion Kinase Inhibitor Results in Accelerated Wound Closure with Decreased Scar Formation

(2018) Kun Ma et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Topology, Geometry, and Mechanics of Z -Plasty

(2018) Elisabetta A. Matsumoto et al.   PHYSICAL REVIEW LETTERS

Mechanical Forces in Cutaneous Wound Healing: Emerging Therapies to Minimize Scar Formation

(2018) Leandra A. Barnes et al.   Advances in Wound Care

The Role of Focal Adhesion Kinase in Keratinocyte Fibrogenic Gene Expression

(2017) Michael Januszyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Abnormal Architecture of Healed Diabetic Ulcers Is the Result of FAK Degradation by Calpain 1

(2017) Wei Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

(2017) Kelly L. Walton et al.   Frontiers in Pharmacology

Integrin signalling regulates YAP and TAZ to control skin homeostasis

(2016) Ahmed Elbediwy et al.   DEVELOPMENT

Wnt/β-catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration

(2016) Dikshya Bastakoty et al.   FASEB JOURNAL

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Anti–TGF-β1 Antibody Therapy in Patients with Diabetic Nephropathy

(2016) James Voelker et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ILK–PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast

(2016) Gang Li et al.   LABORATORY INVESTIGATION

Role of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse

(2016) BING-SHU LI et al.   Molecular Medicine Reports

Verapamil, a Calcium-Channel Blocker, Improves the Wound Healing Process in Rats with Excisional Full-Thickness Skin Wounds Based on Stereological Parameters

(2016) Soheil Ashkani-Esfahani et al.   Advances in Skin & Wound Care

Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar

(2016) Linlin Su et al.   Scientific Reports

Disruption of Calcium Signaling in Fibroblasts and Attenuation of Bleomycin-Induced Fibrosis by Nifedipine

(2015) Subhendu Mukherjee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Emerging Therapies for Scar Prevention

(2015) Lisa Block et al.   Advances in Wound Care

Cadherin Adhesion and Mechanotransduction

(2014) D.E. Leckband et al.   Annual Review of Cell and Developmental Biology

Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction

(2014) R.J. Marjoram et al.   CURRENT MOLECULAR MEDICINE

Mechanotransduction and fibrosis

(2014) Dominik Duscher et al.   JOURNAL OF BIOMECHANICS

β-Catenin–regulated myeloid cell adhesion and migration determine wound healing

(2014) Saeid Amini-Nik et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

(2014) Shaik O. Rahaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Discussion

(2014) Dennis P. Orgill et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

A Randomized Controlled Trial of the embrace Advanced Scar Therapy Device to Reduce Incisional Scar Formation

(2014) Michael T. Longaker et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Loss of Keratinocyte Focal Adhesion Kinase Stimulates Dermal Proteolysis Through Upregulation of MMP9 in Wound Healing

(2013) Victor W. Wong et al.   ANNALS OF SURGERY

Mechanosignaling in Bone Health, Trauma and Inflammation

(2013) Derrick M. Knapik et al.   ANTIOXIDANTS & REDOX SIGNALING

Tissue mechanics and fibrosis

(2013) Rebecca G. Wells   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

β-Catenin protects the epidermis from mechanical stresses

(2013) Samriddha Ray et al.   JOURNAL OF CELL BIOLOGY

Mechanobiological dysregulation of the epidermis and dermis in skin disorders and in degeneration

(2013) Rei Ogawa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

YAP and TAZ Regulate Skin Wound Healing

(2013) Min-Jung Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Scar Zones

(2013) Victor W. Wong et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

The embrace Device Significantly Decreases Scarring following Scar Revision Surgery in a Randomized Controlled Trial

(2013) Angeline F. Lim et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

From Mechanical Force to RhoA Activation

(2012) Elizabeth C. Lessey et al.   BIOCHEMISTRY

German S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids)

(2012) Alexander Nast et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Yap Controls Stem/Progenitor Cell Proliferation in the Mouse Postnatal Epidermis

(2012) Annemiek Beverdam et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Wnt Signaling in Skin Development, Homeostasis, and Disease

(2012) X. Lim et al.   Cold Spring Harbor Perspectives in Biology

Pirfenidone treatment of idiopathic pulmonary fibrosis

(2012) Arata Azuma   Therapeutic Advances in Respiratory Disease

Improving Cutaneous Scar Formation by Controlling the Mechanical Environment

(2011) Geoffrey C. Gurtner et al.   ANNALS OF SURGERY

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

A mechanism of mechanotransduction at the cell-cell interface

(2011) Shigenobu Yonemura   BIOESSAYS

Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts

(2011) Hong Zhou et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

(2011) Lara Buscemi et al.   CURRENT BIOLOGY

G Protein-coupled Receptor Kinase-2 Is a Novel Regulator of Collagen Synthesis in Adult Human Cardiac Fibroblasts

(2011) Karen M. D'Souza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pushing Back: Wound Mechanotransduction in Repair and Regeneration

(2011) Victor W. Wong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Azelnidipine, a New Calcium Channel Blocker, Promotes Skin Wound Healing in Diabetic Rats

(2011) Mansooreh Bagheri et al.   JOURNAL OF SURGICAL RESEARCH

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling

(2011) Victor W Wong et al.   NATURE MEDICINE

Wound Contraction Is Attenuated by Fasudil Inhibition of Rho-Associated Kinase

(2011) Jennifer E. Bond et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis

(2010) Xiaofeng Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

Wnt signaling regulates mitochondrial physiology and insulin sensitivity

(2010) J. C. Yoon et al.   GENES & DEVELOPMENT

Surgical Approaches to Create Murine Models of Human Wound Healing

(2010) Victor W. Wong et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Antagonistic Effect of the Matricellular Signaling Protein CCN3 on TGF-β- and Wnt-Mediated Fibrillinogenesis in Systemic Sclerosis and Marfan Syndrome

(2010) Raphael Lemaire et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Akt-mediated mechanotransduction in murine fibroblasts during hypertrophic scar formation

(2010) Josemaria Paterno et al.   WOUND REPAIR AND REGENERATION

Wnt signaling in skin organogenesis

(2010) Randall B. Widelitz   Organogenesis

Effect of aging on cellular mechanotransduction

(2009) Miaozong Wu et al.   AGEING RESEARCH REVIEWS

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies

(2009) Mark WJ Ferguson et al.   LANCET

Evaluation of a New Wound Closure Device for Linear Surgical Incisions: 3M Steri-Strip S Surgical Skin Closure versus Subcuticular Closure

(2009) Carolyn L. Kerrigan et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Human skin wounds: A major and snowballing threat to public health and the economy

(2009) Chandan K. Sen et al.   WOUND REPAIR AND REGENERATION

Keloids: Pathogenesis, Clinical Features, and Management

(2009) Chuma Chike-Obi et al.   Seminars in Plastic Surgery

Distinct Roles for Mammalian Target of Rapamycin Complexes in the Fibroblast Response to Transforming Growth Factor- 

(2008) R. A. Rahimi et al.   CANCER RESEARCH

A synthetic peptide from transforming growth factor- 1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats

(2008) N. Hermida et al.   CARDIOVASCULAR RESEARCH

Prevention and reduction of scarring in the skin by Transforming Growth Factor beta 3 (TGFβ3): from laboratory discovery to clinical pharmaceutical

(2008) Nick L. Occleston et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Focal Adhesion Kinase Is Important for Fluid Shear Stress–Induced Mechanotransduction in Osteoblasts

(2008) Suzanne RL Young et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Akt Blockade Downregulates Collagen and Upregulates MMP1 in Human Dermal Fibroblasts

(2008) Andreea M. Bujor et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY