Review
Critical Care Medicine
Cormac McCarthy, Nishant Gupta, Simon R. Johnson, Jane J. Yu, Francis X. McCormack
Summary: Lymphangioleiomyomatosis (LAM) is a slowly progressing neoplasm affecting women, leading to lung destruction and respiratory failure. Despite advancements in understanding the disease, further research is needed to better understand its natural history and develop more effective treatments.
LANCET RESPIRATORY MEDICINE
(2021)
Review
Endocrinology & Metabolism
Jian Xu, Wenqi Liu, Fengjuan Fan, Bo Zhang, Fei Zhao, Yu Hu, Chunyan Sun
Summary: TEMPI syndrome is a rare and newly defined multisystemic disease, and its etiology, pathogenesis, and clinical features are largely unknown. Missed diagnosis and misdiagnosis are common due to its diverse and hidden clinical manifestations. Recent studies have reported special clinical manifestations and attempted to identify the pathogenesis of TEMPI syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Caroline R. Baumal, David Sarraf, Tara Bryant, Wei Gui, Nora Muakkassa, Francesco Pichi, Giuseppe Querques, Netan Choudhry, Mehmet Yasin Teke, Andrea Govetto, Alessandro Invernizzi, Dean Eliott, Alain Gaudric, Eduardo Cunha de Souza, Jonathan Naysan, Andrea Lembo, Grace C. Lee, K. Bailey Freund
Summary: This study described the clinical presentation and imaging features of deep retinal haemorrhages in the Henle fibre layer (HFL), and proposed the term 'Henle fiber layer hemorrhage (HH)' to describe this condition. The haemorrhages were associated with various disorders and often resolved spontaneously within 3 months in patients with follow-up.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Gastroenterology & Hepatology
Simona Deidda, Lorena Tora, Davide Firinu, Stefano Del Giacco, Marcello Campagna, Federico Meloni, Germano Orru, Luchino Chessa, Mauro Giovanni Carta, Alessandra Melis, Gaya Spolverato, Roberto Littera, Andrea Perra, Simona Onali, Luigi Zorcolo, Angelo Restivo
Summary: This article reviews the current published data on gastrointestinal involvement in COVID-19, including symptoms, potential biological mechanisms, prognosis, and management, suggesting direct virus infection in the gastrointestinal tract and indicating a possible risk of oral-fecal transmission.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Dermatology
Subuhi Kaul, Ishmeet Kaur, Shilpa Mehta, Archana Singal
Summary: Tuberculosis is a common infectious disease that has been prevalent for centuries and causes a significant number of deaths each year. Cutaneous tuberculosis, a manifestation of the disease on the skin, can be challenging to diagnose and confirm. Dermatologists play a crucial role in early recognition and treatment of this condition.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Rebekka Jerjen, Mandana Nikpour, Thomas Krieg, Christopher P. Denton, Amanda M. Saracino
Summary: Systemic sclerosis is a rare and complex immune-mediated connective tissue disease characterized by progressive skin fibrosis and other clinically heterogeneous features. Recent studies on autoantibodies and bioinformatic analyses have led to a reconsideration of the classification of systemic sclerosis subgroups based on skin manifestations. Early diagnosis and involvement of dermatologists are crucial for improving patient outcomes.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Sheila M. McSweeney, Evangelos A. A. Christou, Marcus Maurer, Clive E. Grattan, Christos Tziotzios, John A. McGrath
Summary: Physical urticaria is a type of urticaria characterized by recurrent wheals and/or angioedema after exposure to physical stimuli. It can be triggered by mechanical, thermal, or solar electromagnetic radiation. Differentiating physical urticaria from other chronic urticarias requires clinical assessment and provocation testing for accurate management. This review summarizes the epidemiology, clinical features, pathogenesis, diagnostic work-up, and management of physical urticaria.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Hao Zhang, Yongqian Bian, Congying Zhao, Yan Wang, Rong Huang, Bin Lin, Danying Qin, Wei Xiong, Jing Li, Xueyong Li
Summary: This study found bacterial colonization in keloids and hypertrophic scars, and the differences in the species and number of colonizing bacteria may cause the heterogeneity of clinical manifestations. The pathogenicity and athletic ability of colonizing bacteria were positively correlated with the degree of hyperplasia and invasions of scars.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Immunology
Xiaonan Song, Wei Wei, Weijia Cheng, Huiyin Zhu, Wei Wang, Haifeng Dong, Jian Li
Summary: This article reviews the clinical characteristics, pathogenesis, diagnosis, and clinical therapy of cerebral malaria, with the aim of providing insights into the development of novel tools for improved treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dermatology
Wael M. Seoudy, Sara M. Mohy El Dien, Talal A. Abdel Reheem, Mona M. Elfangary, Moatasem A. Erfan
Summary: This study suggests that M1 and M2 macrophages play important roles in the pathogenesis of keloid formation. Keloid formation might be a result of an abnormal response to tissue injury with excessive entry of inflammatory cells, including macrophages, into the wound, and the incidence of keloid might be related to a decrease in M1 and an increase in M2.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Ophthalmology
Veronica Castro-Navarro, Francine Behar-Cohen, Woohyok Chang, Antonia M. Joussen, Timothy Y. Y. Lai, Rafael Navarro, Ian Pearce, Yasuo Yanagi, Annabelle A. Okada
Summary: Pachychoroid is a newly described phenotype in retinal disorders, characterized by the presence of hypertrophic or congested vessels under an area of reduced or absent choriocapillaris. Understanding the important features and pathogenesis of disorders within the pachychoroid spectrum may aid in patient management.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Physiology
Surajit Dey, Mathew Suji Eapen, Collin Chia, Archana Vijay Gaikwad, Peter A. B. Wark, Sukhwinder Singh Sohal
Summary: Both asthma and COPD are characterized by airway obstruction, but ACO is not a single disease. Rather, it is a term used clinically to describe overlapping clinical phenotypes of chronic airways disease with different underlying mechanisms. Understanding the pathology of ACO, specifically the airway remodeling changes and inflammation aspects, is crucial for better management.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Hk Bjornsson, Es Bjornsson
Summary: Drug-induced liver injury (DILI) is an important adverse event that can range from mild enzyme elevations to severe liver failure or death. Different types of DILI and the role of the immune system in its pathogenesis have been identified. The diagnosis of DILI remains a challenge due to varying biochemical profiles and multiple clinical signatures of different drugs. Multicenter studies and public websites have provided tools for physicians to investigate suspected DILI cases.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Medicine, General & Internal
Wenli Qi, Xinyue Xiao, Jing Tong, Nengqiang Guo
Summary: Keloid is a pathological scar that forms higher than the skin surface following skin damage. Various treatment methods, including surgical intervention, physiotherapy, drug therapy, and biological therapy, have been developed. This paper reviews recent therapeutic progress and offers valuable insights for clinical treatment.
FRONTIERS IN MEDICINE
(2023)
Review
Clinical Neurology
Lisha Tang, Qianyi Huang, Zhen Qin, Xiangqi Tang
Summary: CIDP patients with autoantibodies represent a minority with distinct pathogenic mechanisms, histopathology, clinical manifestations, and therapeutic responses compared to those without autoantibodies. Therefore, CIDP with autoantibodies should be considered as an independent disease entity rather than just a subtype of CIDP.
JOURNAL OF NEUROLOGY
(2021)
