Chimeric antigen receptor signaling: Functional consequences and design implications

Engineering and Design of Chimeric Antigen Receptors

(2019) Sonia Guedan et al.   Molecular Therapy-Methods & Clinical Development

An immunoproteomic approach to characterize the CAR interactome and signalosome

(2019) Maria C. Ramello et al.   Science Signaling

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

(2019) Mohamed-Reda Benmebarek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells

(2019) Esther Drent et al.   CLINICAL CANCER RESEARCH

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

(2019) Katrin Mestermann et al.   Science Translational Medicine

A guide to manufacturing CAR T cell therapies

(2018) Philipp Vormittag et al.   CURRENT OPINION IN BIOTECHNOLOGY

Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells

(2018) Wei Xiong et al.   MOLECULAR THERAPY

Rewiring T-cell responses to soluble factors with chimeric antigen receptors

(2018) ZeNan L Chang et al.   Nature Chemical Biology

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

A novel chimeric antigen receptor containing a JAK–STAT signaling domain mediates superior antitumor effects

(2018) Yuki Kagoya et al.   NATURE MEDICINE

Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

(2018) John R. James   Science Signaling

TCR Signaling: Mechanisms of Initiation and Propagation

(2018) Adam H. Courtney et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex

(2018) Caleb R. Glassman et al.   Cell Reports

Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

(2018) Neel H Shah et al.   eLife

Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

(2018) John R. James   Science Signaling

Programming CAR-T cells to kill cancer

(2018) Louai Labanieh et al.   Nature Biomedical Engineering

Computational Model of Chimeric Antigen Receptors Explains Site-Specific Phosphorylation Kinetics

(2018) Jennifer A. Rohrs et al.   BIOPHYSICAL JOURNAL

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

(2018) Leah V. Sibener et al.   CELL

Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function

(2018) Alexander I. Salter et al.   Science Signaling

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

(2017) Le Qin et al.   Journal of Hematology & Oncology

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

Ionic CD3−Lck interaction regulates the initiation of T-cell receptor signaling

(2017) Lunyi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

CAR T Cells Releasing IL-18 Convert to T-Bet high FoxO1 low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

(2017) Markus Chmielewski et al.   Cell Reports

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants

(2017) Giedre Krenciute et al.   Cancer Immunology Research

Signaling and Polarized Communication Across the T Cell Immunological Synapse

(2016) Michael L. Dustin et al.   Annual Review of Cell and Developmental Biology

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

(2016) Omkar U. Kawalekar et al.   IMMUNITY

Correction for Pageon et al., Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

(2016)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Structural Model of the Extracellular Assembly of the TCR-CD3 Complex

(2016) Aswin Natarajan et al.   Cell Reports

Fine-tuning the CAR spacer improves T-cell potency

(2016) Norihiro Watanabe et al.   OncoImmunology

Clinical manufacturing of CAR T cells: foundation of a promising therapy

(2016) Xiuyan Wang et al.   Molecular Therapy-Oncolytics

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

(2015) D Sommermeyer et al.   LEUKEMIA

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

The pharmacology of second-generation chimeric antigen receptors

(2015) Sjoukje J. C. van der Stegen et al.   NATURE REVIEWS DRUG DISCOVERY

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

(2015) David L. Porter et al.   Science Translational Medicine

Engineering CAR-T cells: Design concepts

(2015) Shivani Srivastava et al.   TRENDS IN IMMUNOLOGY

Functional Tuning of CARs Reveals Signaling Threshold above Which CD8+ CTL Antitumor Potency Is Attenuated due to Cell Fas-FasL-Dependent AICD

(2015) A. Kunkele et al.   Cancer Immunology Research

IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumorsin vivo

(2015) Mythili Koneru et al.   OncoImmunology

Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

(2015) Hannah Karlsson et al.   PLoS One

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

(2014) Y. Xu et al.   BLOOD

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

(2014) Ondrej Stepanek et al.   CELL

GSK-3 - at the crossroads of cell death and survival

(2014) U. Maurer et al.   JOURNAL OF CELL SCIENCE

Molecular architecture of the αβ T cell receptor–CD3 complex

(2014) Michael E. Birnbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor

(2014) Javier Casas et al.   Nature Communications

CD3ζ-based chimeric antigen receptors mediate T cell activation viacis- andtrans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

(2013) J. S. Bridgeman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells

(2013) M. Hudecek et al.   CLINICAL CANCER RESEARCH

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

(2012) John R. James et al.   NATURE

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

Basic residues in the T-cell receptor   cytoplasmic domain mediate membrane association and modulate signaling

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

The Optimal Antigen Response of Chimeric Antigen Receptors Harboring the CD3  Transmembrane Domain Is Dependent upon Incorporation of the Receptor into the Endogenous TCR/CD3 Complex

(2010) J. S. Bridgeman et al.   JOURNAL OF IMMUNOLOGY

The structural basis for intramembrane assembly of an activating immunoreceptor complex

(2010) Matthew E Call et al.   NATURE IMMUNOLOGY

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

An Enigmatic Tail of CD28 Signaling

(2010) J. S. Boomer et al.   Cold Spring Harbor Perspectives in Biology

The promise and potential pitfalls of chimeric antigen receptors

(2009) Michel Sadelain et al.   CURRENT OPINION IN IMMUNOLOGY

Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication

(2009) Xiao-Song Zhong et al.   MOLECULAR THERAPY

Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities

(2008) Matthias Wölfl et al.   CYTOMETRY PART A