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Title
Immunogenicity of Protein Therapeutics: A Lymph Node Perspective
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-05-14
DOI
10.3389/fimmu.2020.00791
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- (2019) Antonino Cassotta et al. NATURE MEDICINE
- Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation
- (2019) James W. Austin et al. Science Translational Medicine
- Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
- (2019) Aikaterini Alexaki et al. Scientific Reports
- Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB
- (2019) Cees E. van der Poel et al. Cell Reports
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- (2019) Kimberly Shankwitz et al. AGING CELL
- Selection of a Ligand-Binding Neutralizing Antibody Assay for Benralizumab: Comparison with an Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) Cell-Based Assay
- (2018) Yuling Wu et al. AAPS Journal
- Characterization of drug-neutralizing antibodies in patients with Fabry disease during infusion
- (2018) Malte Lenders et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- T-cell–mediated immune response to pneumococcal conjugate vaccine (PCV-13) and tetanus toxoid vaccine in patients with moderate-to-severe psoriasis during tofacitinib treatment
- (2018) Kevin L. Winthrop et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Safety, Tolerability, and Pharmacokinetics of MEDI8897, an Extended Half-Life Single-Dose Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody Administered as a Single Dose to Healthy Preterm Infants
- (2018) Joseph B. Domachowske et al. PEDIATRIC INFECTIOUS DISEASE JOURNAL
- The B-Cell Follicle in HIV Infection: Barrier to a Cure
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- (2018) Tom S. Weber Frontiers in Immunology
- Dose-Dependent Effect of Enzyme Replacement Therapy on Neutralizing Antidrug Antibody Titers and Clinical Outcome in Patients with Fabry Disease
- (2018) Malte Lenders et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers
- (2018) Talar Tokatlian et al. SCIENCE
- Development and organization of the secondary and tertiary lymphoid organs: Influence of microbial and food antigens
- (2018) Thea Magrone et al. Endocrine Metabolic & Immune Disorders-Drug Targets
- Improving Immunotherapy Through Glycodesign
- (2018) Matthew J. Buettner et al. Frontiers in Immunology
- Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
- (2017) Jonatan Ersching et al. IMMUNITY
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- (2017) Myriam Baratin et al. IMMUNITY
- Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis
- (2017) Lucas Onder et al. IMMUNITY
- Dendritic cell and antigen dispersal landscapes regulate T cell immunity
- (2017) Michael Y. Gerner et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Persistency of Neutralizing Anti-Interferon-β Antibodies in Patients with Multiple Sclerosis Treated with Subcutaneous Interferon-β Depends on Antibody Titers, IgG Subclasses, and Affinity Maturation
- (2017) Irena Dujmovic et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Essential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response
- (2017) Aleksandr Barinov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The microanatomic segregation of selection by apoptosis in the germinal center
- (2017) Christian T. Mayer et al. SCIENCE
- Immunogenicity of Therapeutic Antibodies
- (2017) Karien Bloem et al. THERAPEUTIC DRUG MONITORING
- The Lymph Node in HIV Pathogenesis
- (2017) Yiannis Dimopoulos et al. Current HIV/AIDS Reports
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- (2017) Heather L. Thompson et al. Frontiers in Immunology
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- (2017) Robert J. Moots et al. PLoS One
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- (2016) V. D. Nazarov et al. BIOCHEMISTRY-MOSCOW
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- (2016) Sadegh Eivazi et al. BIOMEDICINE & PHARMACOTHERAPY
- Germinal Center B Cell Dynamics
- (2016) Luka Mesin et al. IMMUNITY
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- (2016) Yotam E. Bar-Ephraïm et al. IMMUNOLOGICAL REVIEWS
- Regulation of germinal center B-cell differentiation
- (2016) Yang Zhang et al. IMMUNOLOGICAL REVIEWS
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- (2016) M. A. Hauser et al. JOURNAL OF LEUKOCYTE BIOLOGY
- T cell and reticular network co-dependence in HIV infection
- (2016) Graham M. Donovan et al. JOURNAL OF THEORETICAL BIOLOGY
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- (2016) Alena Roth et al. PLoS One
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- (2016) Farideh Sabri et al. Retrovirology
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- (2013) Iain Comerford et al. CYTOKINE & GROWTH FACTOR REVIEWS
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- Immunogenicity to Biologics: Mechanisms, Prediction and Reduction
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- Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas
- (2012) G. D. Victora et al. BLOOD
- CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation
- (2012) Joanna R. Groom et al. IMMUNITY
- CD4 T follicular helper cell dynamics during SIV infection
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- Marketed therapeutic antibodies compendium
- (2012) Janice M. Reichert mAbs
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- (2011) Shane Crotty Annual Review of Immunology
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- (2011) Xiaoming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2011) Tanja A. Schwickert et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2010) Gabriel D. Victora et al. CELL
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- (2010) Alexandre Garin et al. IMMUNITY
- The germinal center reaction
- (2010) Dominique Gatto et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
- (2010) Michelle A. Linterman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism
- (2010) Dimitra Zotos et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2010) A. C. Poholek et al. JOURNAL OF IMMUNOLOGY
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- (2009) Kathleen P. Pratt et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- Inhibitors in factor IX deficiency a report of the ISTH-SSC international FIX inhibitor registry (1997-2006)
- (2009) M. CHITLUR et al. HAEMOPHILIA
- The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment
- (2009) Di Yu et al. IMMUNITY
- Dendritic Cells and Monocyte/Macrophages That Create the IL-6/APRIL-Rich Lymph Node Microenvironments Where Plasmablasts Mature
- (2009) E. Mohr et al. JOURNAL OF IMMUNOLOGY
- Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response
- (2009) N. H. Ruddle et al. JOURNAL OF IMMUNOLOGY
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- (2009) R. J. Johnston et al. SCIENCE
- Bcl6 Mediates the Development of T Follicular Helper Cells
- (2009) R. I. Nurieva et al. SCIENCE
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- (2009) D. Depoil et al. Science Signaling
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- (2008) T R D J Radstake et al. ANNALS OF THE RHEUMATIC DISEASES
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- (2008) Christine H. Chung et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2007) Benjamin Leader et al. NATURE REVIEWS DRUG DISCOVERY
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