- Home
- Publications
- Publication Search
- Publication Details
Title
Immunogenicity to Biologics: Mechanisms, Prediction and Reduction
Authors
Keywords
-
Journal
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
Volume 60, Issue 5, Pages 331-344
Publisher
Springer Nature
Online
2012-08-28
DOI
10.1007/s00005-012-0189-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Influence of the HLA-DRB1 Genotype on Antibody Development to Interferon Beta in Multiple Sclerosis
- (2011) Dorothea Buck et al. ARCHIVES OF NEUROLOGY
- Determinants of antigenicity and specificity in immune response for protein sequences
- (2011) Yulong Wang et al. BMC BIOINFORMATICS
- Immediate adverse reactions to biologicals: from pathogenic mechanisms to prophylactic management
- (2011) Alessandra Vultaggio et al. Current Opinion in Allergy and Clinical Immunology
- Antibody-Specified B-Cell Epitope Prediction in Line with the Principle of Context-Awareness
- (2011) Liang Zhao et al. IEEE-ACM Transactions on Computational Biology and Bioinformatics
- Impaired in vivo CD4+ T cell expansion and differentiation in aged mice is not solely due to T cell defects: Decreased stimulation by aged dendritic cells
- (2011) Luciana F. Pereira et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Persistency of neutralizing antibodies depends on titer and interferon-beta preparation
- (2011) Harald Hegen et al. Multiple Sclerosis Journal
- How were new medicines discovered?
- (2011) David C. Swinney et al. NATURE REVIEWS DRUG DISCOVERY
- Coupling of Aggregation and Immunogenicity in Biotherapeutics: T- and B-Cell Immune Epitopes May Contain Aggregation-Prone Regions
- (2011) Sandeep Kumar et al. PHARMACEUTICAL RESEARCH
- Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice
- (2011) Miranda M. C. van Beers et al. PHARMACEUTICAL RESEARCH
- Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift
- (2011) J. R. Cantor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Virus aggregating peptide enhances the cell-mediated response to influenza virus vaccine
- (2011) Jeremy C. Jones et al. VACCINE
- OPTIMIZATION OF THERAPEUTIC PROTEINS TO DELETE T-CELL EPITOPES WHILE MAINTAINING BENEFICIAL RESIDUE INTERACTIONS
- (2011) ANDREW S. PARKER et al. Journal of Bioinformatics and Computational Biology
- PEGylation of therapeutic proteins
- (2010) Simona JevsÌevar et al. Biotechnology Journal
- Characterization of anti-interferon-α antibodies appearing during recombinant interferon-α2a treatment
- (2010) L. E. RöNNBLOM et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs
- (2010) J A DiMasi et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Subset analysis of patients experiencing clinical events of a potentially immunogenic nature in the pivotal clinical trials of tocilizumab for rheumatoid arthritis: Evaluation of an antidrug antibody ELISA using clinical adverse event-driven immunogenicity testing
- (2010) Kay Stubenrauch et al. CLINICAL THERAPEUTICS
- HLA-DR-restricted T-cell responses to factor VIII epitopes in a mild haemophilia A family with missense substitution A2201P
- (2010) R. A. ETTINGER et al. HAEMOPHILIA
- Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems
- (2010) Deepa Mohanan et al. JOURNAL OF CONTROLLED RELEASE
- Complement drives Th17 cell differentiation and triggers autoimmune arthritis
- (2010) Motomu Hashimoto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Immune Complex-Mediated Enhancement of Secondary Antibody Responses
- (2010) C. L. Goins et al. JOURNAL OF IMMUNOLOGY
- On the Role of Aggregates in the Immunogenicity of Recombinant Human Interferon Beta in Patients with Multiple Sclerosis
- (2010) Miranda M.C. van Beers et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Impact of Product-Related Factors on Immunogenicity of Biotherapeutics
- (2010) Satish Kumar Singh JOURNAL OF PHARMACEUTICAL SCIENCES
- HLA antigens in hemophiliacs A with or without factor VIII antibodies in a Venezuelan Mestizo population
- (2010) N. Simonney et al. TISSUE ANTIGENS
- Anti-infliximab IgE and non-IgE antibodies and induction of infusion-related severe anaphylactic reactions
- (2009) A. Vultaggio et al. ALLERGY
- Reducing risk, improving outcomes: Bioengineering less immunogenic protein therapeutics
- (2009) Anne S. De Groot et al. CLINICAL IMMUNOLOGY
- Prediction of MHC-Peptide Binding: A Systematic and Comprehensive Overview
- (2009) Esther Lafuente et al. CURRENT PHARMACEUTICAL DESIGN
- C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells
- (2009) Donald J. Weaver et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Strategies to Improve the Effect of Vaccination in the Elderly: the Vaccine Producer's Perspective
- (2009) B. Guy JOURNAL OF COMPARATIVE PATHOLOGY
- Antibodies against interferon-beta in multiple sclerosis
- (2009) Nina Karin Aarskog et al. JOURNAL OF NEUROIMMUNOLOGY
- Evaluation of the Immuno-Stimulatory Potential of Stopper Extractables and Leachables by Using Dendritic Cells as Readout
- (2009) Robert Mueller et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Effect of Route of Administration of Human Recombinant Factor VIII on Its Immunogenicity in Hemophilia A Mice
- (2009) Aaron Peng et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies
- (2009) Rafael Ponce et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- HLA-DRB1∗0401 and HLA-DRB1∗0408 Are Strongly Associated with the Development of Antibodies against Interferon-β Therapy in Multiple Sclerosis
- (2008) Steve Hoffmann et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis
- (2008) T R D J Radstake et al. ANNALS OF THE RHEUMATIC DISEASES
- Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis
- (2008) P. N. Lalli et al. BLOOD
- Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation
- (2008) K. Li et al. BLOOD
- Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"
- (2008) A. S. De Groot et al. BLOOD
- Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells
- (2008) Michael G. Strainic et al. IMMUNITY
- Safety-Related Regulatory Actions for Biologicals Approved in the United States and the European Union
- (2008) JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Predicting linear B‐cell epitopes using string kernels
- (2008) Yasser EL‐Manzalawy et al. JOURNAL OF MOLECULAR RECOGNITION
- (Re)defining biopharmaceutical
- (2008) Ronald A Rader NATURE BIOTECHNOLOGY
- The association of anti-r-HuEpo-associated pure red cell aplasia with HLA-DRB1*09-DQB1*0309
- (2008) K. Praditpornsilpa et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Protein therapeutics: a summary and pharmacological classification
- (2007) Benjamin Leader et al. NATURE REVIEWS DRUG DISCOVERY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started