Protein Supramolecular Structures: From Self-Assembly to Nanovaccine Design

Controlling the Self-Assembly of Biomolecules into Functional Nanomaterials through Internal Interactions and External Stimulations: A Review

(2019) Li Wang et al.   Nanomaterials

Presentation and Delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand via Elongated Plant Viral Nanoparticle Enhances Antitumor Efficacy

(2019) Duc H. T. Le et al.   ACS Nano

Attachment of flagellin enhances the immunostimulatory activity of a hemagglutinin-ferritin nano-cage

(2019) Emerson B. Lee et al.   Nanomedicine-Nanotechnology Biology and Medicine

Functional Amyloids

(2019) Daniel Otzen et al.   Cold Spring Harbor Perspectives in Biology

Soluble Antigen Arrays Displaying Mimotopes Direct the Response of Diabetogenic T Cells

(2019) Martin A. Leon et al.   ACS Chemical Biology

Guiding the Morphology of Amyloid Assemblies by Electrostatic Capping: from Polymorphic Twisted Fibrils to Uniform Nanorods

(2019) Ximena Zottig et al.   Small

Bacterial Protein Toll-Like-Receptor Agonists: A Novel Perspective on Vaccine Adjuvants

(2019) Sudeep Kumar et al.   Frontiers in Immunology

Tailor-Made Functional Peptide Self-Assembling Nanostructures

(2018) Moran Amit et al.   ADVANCED MATERIALS

Synthetic approaches to construct viral capsid-like spherical nanomaterials

(2018) Kazunori Matsuura   CHEMICAL COMMUNICATIONS

IAPP and type 1 diabetes: implications for immunity, metabolism and islet transplants

(2018) Heather C Denroche et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Applications and perspectives of nanomaterials in novel vaccine development

(2018) Yingbin Shen et al.   MedChemComm

Polymer-Based Nanomaterials and Applications for Vaccines and Drugs

(2018) Jinyu Han et al.   Polymers

New Routes and Opportunities for Modular Construction of Particulate Vaccines: Stick, Click, and Glue

(2018) Karl D. Brune et al.   Frontiers in Immunology

Engineering and evaluation of amyloid assemblies as nanovaccine against the Chikungunya virus

(2018) Margaryta Babych et al.   Nanoscale

Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity

(2017) Li Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Tuning underwater adhesion with cation–π interactions

(2017) Matthew A. Gebbie et al.   Nature Chemistry

A structural model of flagellar filament switching across multiple bacterial species

(2017) Fengbin Wang et al.   Nature Communications

A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers

(2017) Yaoying Wu et al.   ACS Biomaterials-Science & Engineering

A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers

(2017) Yaoying Wu et al.   ACS Biomaterials Science & Engineering

Classification of self-assembling protein nanoparticle architectures for applications in vaccine design

(2017) G. Indelicato et al.   Royal Society Open Science

Switching the Immunogenicity of Peptide Assemblies Using Surface Properties

(2016) Yi Wen et al.   ACS Nano

Amyloid Fibrils as Building Blocks for Natural and Artificial Functional Materials

(2016) Tuomas P. J. Knowles et al.   ADVANCED MATERIALS

Vaccine technologies: From whole organisms to rationally designed protein assemblies

(2016) Christopher P. Karch et al.   BIOCHEMICAL PHARMACOLOGY

Viral-mimicking protein nanoparticle vaccine for eliciting anti-tumor responses

(2016) Nicholas M. Molino et al.   BIOMATERIALS

The design of symmetric protein nanomaterials comes of age in theory and practice

(2016) Todd O Yeates et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates

(2016) Clara Westwell-Roper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Supramolecular biomaterials

(2016) Matthew J. Webber et al.   NATURE MATERIALS

Structure of the Neisseria meningitidis Type IV pilus

(2016) Subramania Kolappan et al.   Nature Communications

A Modular Vaccine Development Platform Based on Sortase-Mediated Site-Specific Tagging of Antigens onto Virus-Like Particles

(2016) Shubing Tang et al.   Scientific Reports

Self-assembling protein nanoparticles in the design of vaccines

(2016) Jacinto López-Sagaseta et al.   Computational and Structural Biotechnology Journal

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

(2016) Karl D. Brune et al.   Scientific Reports

Post-Translational Modification of Bionanoparticles as a Modular Platform for Biosensor Assembly

(2015) Qing Sun et al.   ACS Nano

Controlling the Assembly of Coiled-Coil Peptide Nanotubes

(2015) Franziska Thomas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure, Dynamics, Assembly, and Evolution of Protein Complexes

(2015) Joseph A. Marsh et al.   Annual Review of Biochemistry

Hybrid flagellin as a T cell independent vaccine scaffold

(2015) Kaila M. Bennett et al.   BMC BIOTECHNOLOGY

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

(2015) Masaru Kanekiyo et al.   CELL

Sortase A-mediated multi-functionalization of protein nanoparticles

(2015) Qi Chen et al.   CHEMICAL COMMUNICATIONS

Secrets of a covalent interaction for biomaterials and biotechnology: SpyTag and SpyCatcher

(2015) Samuel C Reddington et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Supramolecular peptide vaccines: tuning adaptive immunity

(2015) Yi Wen et al.   CURRENT OPINION IN IMMUNOLOGY

His-tagged norovirus-like particles: A versatile platform for cellular delivery and surface display

(2015) Tiia Koho et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Sizing the optimal dimensions of a vaccine delivery system: a particulate matter

(2015) Bram Slütter et al.   Expert Opinion on Drug Delivery

Role of scavenger receptors in dendritic cell function

(2015) Dan Wang et al.   HUMAN IMMUNOLOGY

Flagellin as Carrier and Adjuvant in Cocaine Vaccine Development

(2015) Jonathan W. Lockner et al.   MOLECULAR PHARMACEUTICS

Local and macroscopic electrostatic interactions in single α-helices

(2015) Emily G Baker et al.   Nature Chemical Biology

A Novel Virus-Like Particle Based Vaccine Platform Displaying the Placental Malaria Antigen VAR2CSA

(2015) Susan Thrane et al.   PLoS One

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis

(2015) Phuong Trang Nguyen et al.   Journal of Diabetes Research

The Hydrophobic Effect Revisited-Studies with Supramolecular Complexes Imply High-Energy Water as a Noncovalent Driving Force

(2014) Frank Biedermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-adjuvanting vaccine against group A streptococcus: Application of fibrillized peptide and immunostimulatory lipid as adjuvant

(2014) Fazren Azmi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Autologous albumin enhances the humoral immune response to capsular polysaccharide covalently coattached to bacteria-sized latex beads

(2014) Jesus Colino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Extracellular environment modulates the formation and propagation of particular amyloid structures

(2014) Laura Westergard et al.   MOLECULAR MICROBIOLOGY

Novel Anti-Nicotine Vaccine Using a Trimeric Coiled-Coil Hapten Carrier

(2014) Keith D. Miller et al.   PLoS One

Prediction and Analysis of Surface Hydrophobic Residues in Tertiary Structure of Proteins

(2014) Shambhu Malleshappa Gowder et al.   TheScientificWorldJOURNAL

Effectiveness of a novel immunogenic nanoparticle platform for Toxoplasma peptide vaccine in HLA transgenic mice

(2014) Kamal El Bissati et al.   VACCINE

Titrating T-Cell Epitopes within Self-Assembled Vaccines Optimizes CD4+ Helper T Cell and Antibody Outputs

(2014) Rebecca R. Pompano et al.   Advanced Healthcare Materials

VaxCelerate II: Rapid development of a self-assembling vaccine for Lassa fever

(2014) Pierre Leblanc et al.   Human Vaccines & Immunotherapeutics

Biomimetic Protein Nanoparticles Facilitate Enhanced Dendritic Cell Activation and Cross-Presentation

(2013) Nicholas M. Molino et al.   ACS Nano

Molecular Structure of RADA16-I Designer Self-Assembling Peptide Nanofibers

(2013) Ashley R. Cormier et al.   ACS Nano

Size effect of amphiphilic poly(γ-glutamic acid) nanoparticles on cellular uptake and maturation of dendritic cells in vivo

(2013) Fumiaki Shima et al.   Acta Biomaterialia

Click Chemistry for Drug Development and Diverse Chemical–Biology Applications

(2013) Prakasam Thirumurugan et al.   CHEMICAL REVIEWS

New designed protein assemblies

(2013) Sabina Božič et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Practical approaches to designing novel protein assemblies

(2013) Neil P King et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

The respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid

(2013) S. E. Bakker et al.   JOURNAL OF GENERAL VIROLOGY

Structural Analysis and Optimization of the Covalent Association between SpyCatcher and a Peptide Tag

(2013) Long Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Colocalized Delivery of Adjuvant and Antigen Using Nanolipoprotein Particles Enhances the Immune Response to Recombinant Antigens

(2013) Nicholas O. Fischer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Novel Subnucleocapsid Nanoplatform for Mucosal Vaccination against Influenza Virus That Targets the Ectodomain of Matrix Protein 2

(2013) P.-L. Herve et al.   JOURNAL OF VIROLOGY

Nanoclusters self-assembled from conformation-stabilized influenza M2e as broadly cross-protective influenza vaccines

(2013) Li Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

Engineering synthetic vaccines using cues from natural immunity

(2013) Darrell J. Irvine et al.   NATURE MATERIALS

Effects of Microparticle Size and Fc Density on Macrophage Phagocytosis

(2013) Patricia Pacheco et al.   PLoS One

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

(2013) A. W. P. Fitzpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Antigenic peptide nanofibers elicit adjuvant-free CD8+ T cell responses

(2013) Charles B. Chesson et al.   VACCINE

Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases

(2013) Rodrigo Morales et al.   PLoS Pathogens

Mechanisms of Action of Adjuvants

(2013) Sunita Awate et al.   Frontiers in Immunology

Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope

(2012) Jai S. Rudra et al.   BIOMATERIALS

a Totally Synthetic, Self-Assembling, Adjuvant-Free MUC1 Glycopeptide Vaccine for Cancer Therapy

(2012) Zhi-Hua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoparticle Hydrophobicity Dictates Immune Response

(2012) Daniel F. Moyano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Organisation of Ebola Virus Reveals a Capacity for Extensive, Modular Polyploidy

(2012) Daniel R. Beniac et al.   PLoS One

Protective Antibody and CD8+ T-Cell Responses to the Plasmodium falciparum Circumsporozoite Protein Induced by a Nanoparticle Vaccine

(2012) Stephen A. Kaba et al.   PLoS One

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

(2012) B. Zakeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy

(2012) N. P. King et al.   SCIENCE

Functional Supramolecular Polymers

(2012) T. Aida et al.   SCIENCE

Rethinking the term “pi-stacking”

(2012) Chelsea R. Martinez et al.   Chemical Science

Structure of human adenovirus

(2012) Glen R Nemerow et al.   Current Opinion in Virology

Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form

(2011) K. El Omari et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Surface Functionalization of Virus-Like Particles by Direct Conjugation Using Azide−Alkyne Click Chemistry

(2011) Kedar G. Patel et al.   BIOCONJUGATE CHEMISTRY

Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity

(2011) P. J. Tacken et al.   BLOOD

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Self-Assembly in the Ferritin Nano-Cage Protein Superfamily

(2011) Yu Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Selective Molecular Recognition in Amyloid Growth and Transmission and Cross-Species Barriers

(2011) Buyong Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

A pH-responsive coiled-coil peptide hydrogel

(2011) Nicholas L. Fletcher et al.   Soft Matter

Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults

(2011) Christine B. Turley et al.   VACCINE

SplitCore: An exceptionally versatile viral nanoparticle for native whole protein display regardless of 3D structure

(2011) Andreas Walker et al.   Scientific Reports

Herpesvirus capsid assembly: insights from structural analysis

(2011) Jay C Brown et al.   Current Opinion in Virology

Amphiphilic Poly(Amino Acid) Nanoparticles Induce Size-Dependent Dendritic Cell Maturation

(2010) Hyungjin Kim et al.   ADVANCED FUNCTIONAL MATERIALS

Self-Assembled Synthetic Viral Capsids from a 24-mer Viral Peptide Fragment

(2010) Kazunori Matsuura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immune responses to coiled coil supramolecular biomaterials

(2010) Jai S. Rudra et al.   BIOMATERIALS

Building fibrous biomaterials from α-helical and collagen-like coiled-coil peptides

(2010) Derek N. Woolfson   BIOPOLYMERS

Toll-like receptors 1 and 2 cooperatively mediate immune responses to curli, a common amyloid from enterobacterial biofilms

(2010) Çagla Tükel et al.   CELLULAR MICROBIOLOGY

Next-generation peptide nanomaterials: molecular networks, interfaces and supramolecular functionality

(2010) Mischa Zelzer et al.   CHEMICAL SOCIETY REVIEWS

Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses

(2010) Moses O Oyewumi et al.   Expert Review of Vaccines

Adaptive immunity

(2010) Francisco A. Bonilla et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases

(2010) R. Morales et al.   JOURNAL OF NEUROSCIENCE

Extended Apolar β-Peptide Foldamers: The Role of Axis Chirality on β-Peptide Sheet Stability

(2010) Gábor Pohl et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Conformational change of flagellin for polymorphic supercoiling of the flagellar filament

(2010) Saori Maki-Yonekura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

(2009) Parag Aggarwal et al.   ADVANCED DRUG DELIVERY REVIEWS

Aromatic Interactions Promote Self-Association of Collagen Triple-Helical Peptides to Higher-Order Structures

(2009) Karunakar Kar et al.   BIOCHEMISTRY

Heterogeneity of CD4+ memory T cells: Functional modules for tailored immunity

(2009) Federica Sallusto et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Nonadjuvanted Polypeptide Nanoparticle Vaccine Confers Long-Lasting Protection against Rodent Malaria

(2009) S. A. Kaba et al.   JOURNAL OF IMMUNOLOGY

The Common Architecture of Cross-β Amyloid

(2009) Thomas R. Jahn et al.   JOURNAL OF MOLECULAR BIOLOGY

Invariant Polymorphism in Virus Capsid Assembly

(2009) Hung D. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A self-assembling peptide acting as an immune adjuvant

(2009) J. S. Rudra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus

(2009) R. G. Tawar et al.   SCIENCE

A Self-Assembled Protein Nanotube with High Aspect Ratio

(2009) Frederico F. Miranda et al.   Small

The Oligomerization Domain of C4-Binding Protein (C4bp) Acts as an Adjuvant, and the Fusion Protein Comprised of the 19-Kilodalton Merozoite Surface Protein 1 Fused with the Murine C4bp Domain Protects Mice against Malaria

(2008) S. A. Ogun et al.   INFECTION AND IMMUNITY

Immunomodulatory biomaterials

(2008) Surya K. Mallapragada et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Self-Assembly of α-Helical Coiled Coil Nanofibers

(2008) He Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle Biodistribution

(2008) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS

Mechanisms of Size Control and Polymorphism in Viral Capsid Assembly

(2008) Oren M. Elrad et al.   NANO LETTERS

Sequence dependence of kinetics and morphology of collagen model peptide self-assembly into higher order structures

(2008) Karunakar Kar et al.   PROTEIN SCIENCE

Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin

(2007) James W. Huleatt et al.   VACCINE