Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors

Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors

(2020) Jordan L. Doman et al.   NATURE BIOTECHNOLOGY

Continuous evolution of SpCas9 variants compatible with non-G PAMs

(2020) Shannon M. Miller et al.   NATURE BIOTECHNOLOGY

BIG-TREE: Base-Edited Isogenic hPSC Line Generation Using a Transient Reporter for Editing Enrichment

(2020) Nicholas Brookhouser et al.   Stem Cell Reports

Engineering of high-precision base editors for site-specific single nucleotide replacement

(2019) Junjie Tan et al.   Nature Communications

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos

(2019) Erwei Zuo et al.   SCIENCE

Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice

(2019) Shuai Jin et al.   SCIENCE

Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9

(2019) Hong-Xia Zhang et al.   MOLECULAR THERAPY

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

(2019) Tony P. Huang et al.   NATURE BIOTECHNOLOGY

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing

(2019) Erica McGrath et al.   Nature Communications

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

Genome Editing in Induced Pluripotent Stem Cells using CRISPR/Cas9

(2018) Ronen Ben Jehuda et al.   Stem Cell Reviews and Reports

Genome Editing in Induced Pluripotent Stem Cells using CRISPR/Cas9

(2018) Ronen Ben Jehuda et al.   Stem Cell Reviews and Reports

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities

(2018) Jason M Gehrke et al.   NATURE BIOTECHNOLOGY

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

A Review on Electroporation-Based Intracellular Delivery

(2018) Junfeng Shi et al.   MOLECULES

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

Correction to: Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells

(2017) Franziska K. Geis et al.   Retrovirology

Creating a patient carried Men1 gene point mutation on wild type iPSCs locus mediated by CRISPR/Cas9 and ssODN

(2017) Dongsheng Guo et al.   Stem Cell Research

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

(2017) Holly A. Rees et al.   Nature Communications

Functional Restoration of gp91phox-Oxidase Activity by BAC Transgenesis and Gene Targeting in X-linked Chronic Granulomatous Disease iPSCs

(2016) Magdalena Laugsch et al.   MOLECULAR THERAPY

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

(2016) K. Nishida et al.   SCIENCE

Efficient and transgene-free genome editing in wheat through transient expression of CRISPR/Cas9 DNA or RNA

(2016) Yi Zhang et al.   Nature Communications

Somatic TP53 Mutations in the Era of Genome Sequencing

(2016) Pierre Hainaut et al.   Cold Spring Harbor Perspectives in Medicine

Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing

(2016) Yuichiro Miyaoka et al.   Scientific Reports

CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells

(2015) Rowan Flynn et al.   EXPERIMENTAL HEMATOLOGY

SAMHD1 prevents autoimmunity by maintaining genome stability

(2014) Stefanie Kretschmer et al.   ANNALS OF THE RHEUMATIC DISEASES

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

(2014) Faye M. Drawnel et al.   Cell Reports

Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells

(2014) Foad Rouhani et al.   PLoS Genetics

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells

(2013) Su Mi Choi et al.   HEPATOLOGY

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

(2013) Seung Woo Cho et al.   NATURE BIOTECHNOLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

Human induced pluripotent stem cells—from mechanisms to clinical applications

(2012) Katharina Drews et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Aicardi-Goutières Syndrome and Systemic Lupus Erythematosus (SLE) in a 12-Year-Old Boy With SAMHD1 Mutations

(2011) Georgia Ramantani et al.   JOURNAL OF CHILD NEUROLOGY

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

(2010) B.-Y. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells

(2009) Limor Zwi et al.   CIRCULATION

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

(2009) Ángel Raya et al.   NATURE

Hematopoietic and endothelial differentiation of human induced pluripotent stem cells

(2009) Kyung-Dal Choi et al.   STEM CELLS

Retroviral vector silencing during iPS cell induction: An epigenetic beacon that signals distinct pluripotent states

(2008) Akitsu Hotta et al.   JOURNAL OF CELLULAR BIOCHEMISTRY