Article
Endocrinology & Metabolism
Benjamin C. Cossins, Inge van den Munckhof, Joost H. W. Rutten, Marinette van der Graaf, Rinke Stienstra, Leo A. B. Joosten, Mihai G. Netea, Yang Li, Niels P. Riksen
Summary: This study examined the association between adipocyte size, adipose tissue inflammation, systemic inflammation, and metabolic and atherosclerotic complications of obesity in a sex-specific manner. The results showed that inflammation in abdominal subcutaneous adipose tissue is more related to metabolic complications than atherosclerotic complications, and there are significant sex-specific differences in this association.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Laura Brabenec, Katharina E. M. Hellenthal, Melanie Mueller, Sebastian Kintrup, Finnja Zurek-Leffers, Marina Kardell, Mandy Otto, Nana-Maria Wagner
Summary: Procalcitonin contributes to endothelial dysfunction by antagonizing CGRP signaling in obesity, and targeting hyperprocalcitonemia may be a means to preserve endothelial function and reduce comorbidity burden in obese subjects.
Review
Biochemistry & Molecular Biology
Kelly Warmink, Prateeksha Vinod, Nicoline M. Korthagen, Harrie Weinans, Jaqueline L. Rios
Summary: Obesity is associated with osteoarthritis, as it alters adipokine release, increases pro-inflammatory macrophage activity, and affects joint immune regulation. Studying inflammatory macrophage expression and inhibiting inflammatory macrophage phenotype polarization may provide insights into disease pathogenesis and therapy. Imaging techniques and blood-based biomarker analysis can enable early detection of osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Delia-Maria Nicoara, Andrei-Ioan Munteanu, Alexandra-Cristina Scutca, Niculina Mang, Iulius Juganaru, Giorgiana-Flavia Brad, Otilia Marginean
Summary: Childhood obesity is a global concern due to its increasing incidence and potential long-term cardiovascular implications. This study investigated the diagnostic utility of various inflammatory indices in obese children with metabolic syndrome (MetS) and their relationship with cardiometabolic risk biomarkers. The results showed that the systemic immune-inflammation index (SII) had diagnostic value in distinguishing MetS patients among obese children and was positively associated with cardiometabolic risk biomarkers, indicating its potential role as an additional measure of cardiometabolic instability in obese children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Claudia Rodriguez, Ana Sanchez, Javier Saenz-Medina, Mercedes Munoz, Medardo Hernandez, Miguel Lopez, Luis Rivera, Cristina Contreras, Dolores Prieto
Summary: Obesity-induced dysregulation of AMPK activity is the underlying cause of kidney vascular dysfunction, and activation of AMPK improves metabolic state, protects renal endothelial function, and exerts potent vascular antioxidant and anti-inflammatory effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Physiology
Zarah B. Tabrizi, Nada S. Ahmed, Joseph L. Horder, Sarah J. Storr, Andrew V. Benest
Summary: The lymphatic system is a crucial vascular system with diverse functions in physiology and pathology, serving as an interface between the blood vascular and immune system. While much research has focused on phenotypic switching of blood endothelium, less attention has been given to the functional and molecular heterogeneity of the lymphatic system, where transcription factor activity likely plays an important role in controlling cellular responses during lymphatic remodelling.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Mushari Alharbi, Martina Chiurazzi, Gilda Nasti, Espedita Muscariello, Teresa Mastantuono, Christina Koechl, Blossom C. M. Stephan, Oliver M. Shannon, Antonio Colantuoni, Mario Siervo
Summary: This pilot study investigates the combined effects of caloric restriction and dietary nitrate supplementation on metabolic, vascular, and cognitive functions in overweight and obese middle-aged and older adults. The findings suggest that combining caloric restriction with dietary nitrate supplementation could lead to greater improvements in vascular and cognitive functions.
Article
Food Science & Technology
James Coleman Miller, Adhini Kuppuswamy Satheesh Babu, Chrissa Petersen, Umesh D. Wankhade, Michael S. I. I. I. I. Robeson, Madison Nicole Putich, Jennifer Ellen Mueller, Aubrey Sarah O'Farrell, Jae Min Cho, Sree Chintapalli, Thunder Jalili, John David Symons, Pon Velayutham Anandh Babu
Summary: This study found that dietary strawberry consumption can reduce the risk of vascular complications in an animal model of MetS, and this effect is associated with changes in the composition of gut microbes.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Cell Biology
Jingying Chen, Xiuhua Li, Rui Ni, Qi Chen, Qifen Yang, Jianbo He, Lingfei Luo
Summary: The study in zebrafish cerebrovascular injury models reveals that the earliest regenerated blood vessels originate from lymphatic transdifferentiation via Notch activation. This process only occurs in stand-alone lymphatic vessels, while late-regenerated blood vessels form through a different mechanism.
DEVELOPMENTAL CELL
(2021)
Review
Pharmacology & Pharmacy
Alejandra Gonzalez-Loyola, Tatiana V. Petrova
Summary: The lymphatic vasculature plays a crucial role in maintaining body fluid balance, immune surveillance, and dietary fat absorption. Recent studies have shed light on the mechanisms of lymphatic vascular development and function.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Physiology
Tomohiro Shiiya, Masanori Hirashima
Summary: During development, lymphatic endothelial cell (LEC) progenitors differentiate from venous endothelial cells only in limited regions of the body. LEC migration and subsequent tube formation are essential processes for the development of tubular lymphatic vascular network throughout the body. This review discusses the chemotactic factors, LEC-extracellular matrix interactions, and planar cell polarity regulating LEC migration and formation of tubular lymphatic vessels, providing insights into the molecular mechanisms underlying physiological lymphatic vascular development and lymphangiogenesis associated with pathological conditions.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cell Biology
Jun Zhang, Hui-Kai Yuan, Shuo Chen, Zhi-Ren Zhang
Summary: EnNaC, traditionally thought to be restricted to epithelial tissues, has also been found in non-epithelial tissues, particularly in vascular endothelial cells. The expression and regulatory mechanism of EnNaC remain controversial in different species and vessels. EnNaC activation can lead to increased endothelial stiffness and reduced nitric oxide production, but it is essential for maintaining endothelial barrier function in some blood vessels.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Shuzo Kobayashi, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Sumi Hidaka, Takayasu Ohtake
Summary: The prevalence of metabolic syndrome (Mets) was investigated in hemodialysis (HD) patients, along with the validation of waist circumference (WC) criteria using computed tomography (CT) measurement of visceral fatty area (VFA). The study found that Mets was more prevalent in male HD patients (31.9%) compared to female HD patients (13.6%), despite a low proportion of patients with a body mass index over 25 (11.2%). The VFA measured by CT showed a strong positive correlation with WC, and factors such as shorter duration of HD, higher high-sensitive C-reactive protein, and higher Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were associated with Mets in HD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
George E. Davis, Pieter R. Norden, Stephanie L. K. Bowers
CONNECTIVE TISSUE RESEARCH
(2015)
Article
Developmental Biology
David M. Barry, Ke Xu, Stryder M. Meadows, Yi Zheng, Pieter R. Norden, George E. Davis, Ondine Cleaver
Article
Cardiac & Cardiovascular Systems
David M. Barry, Yeon Koo, Pieter R. Norden, Lyndsay A. Wylie, Ke Xu, Chonlarat Wichaidit, D. Berfin Azizoglu, Yi Zheng, Melanie H. Cobb, George E. Davis, Ondine Cleaver
CIRCULATION RESEARCH
(2016)
Article
Medicine, Research & Experimental
Anees Fatima, Ying Wang, Yutaka Uchida, Pieter Norden, Ting Liu, Austin Culver, William H. Dietz, Ford Culver, Meredith Millay, Yoh-suke Mukouyama, Tsutomu Kume
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Biochemistry & Molecular Biology
Kamalendra Singh, Bruno Marchand, Devendra K. Rai, Bechan Sharma, Eleftherios Michailidis, Emily M. Ryan, Kayla B. Matzek, Maxwell D. Leslie, Ariel N. Hagedorn, Zhe Li, Pieter R. Norden, Atsuko Hachiya, Michael A. Parniak, Hong-Tao Xu, Mark A. Wainberg, Stefan G. Sarafianos
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Multidisciplinary Sciences
Pieter R. Norden, Dae Joong Kim, David M. Barry, Ondine B. Cleaver, George E. Davis
Article
Multidisciplinary Sciences
Dae Joong Kim, Pieter R. Norden, Jocelynda Salvador, David M. Barry, Stephanie L. K. Bowers, Ondine Cleaver, George E. Davis
Article
Multidisciplinary Sciences
Pieter R. Norden, Zheying Sun, George E. Davis
Article
Biology
Pieter R. Norden, Amelie Sabine, Ying Wang, Cansaran Saygili Demir, Ting Liu, Tatiana Petrova, Tsutomu Kume
Review
Cell Biology
Pieter R. Norden, Tsutomu Kume
Summary: The lymphatic system is crucial for maintaining fluid and protein balance in the body. Recent research has focused on the formation mechanisms of lymphatic vessels, but abnormalities and diseases in humans remain complex and poorly understood. Different types of junctions in lymphatic vessels play critical roles in maintaining integrity and function, with current knowledge centered around key signaling pathways such as VEGF and RhoA/ROCK.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Can Tan, Pieter R. Norden, Wei Yu, Ting Liu, Naoto Ujiie, Sun Kyong Lee, Xiaocai Yan, Yaryna Dyakiv, Kazushi Aoto, Sagrario Ortega, Isabelle G. De Plaen, Venkatesh Sampath, Tsutomu Kume
Summary: FOXC1 and FOXC2 play vital roles in intestinal regeneration by stimulating CXCL12 and Wnt signaling pathways. Deletion of Foxc1, Foxc2, or both results in defects in vascular regrowth, reduced expression of CXCL12 and RSPO3 in blood endothelial cells and lymphatic endothelial cells respectively, and increased activation of Wnt signaling in intestinal stem cells. Treatment with CXCL12 and RSPO3 rescues the intestinal damage induced by ischemia-reperfusion injury in mutant mice.
Article
Biology
Naoto Ujiie, Pieter R. Norden, Raymond Fang, Lisa Beckmann, Zhen Cai, Junghun Kweon, Ting Liu, Can Tan, Megan S. Kuhn, W. Daniel Stamer, Kazushi Aoto, Susan E. Quaggin, Hao F. Zhang, Tsutomu Kume
Summary: Impaired development of Schlemm's canal and elevated intraocular pressure are observed in mice with NC-specific Foxc2 deletion, suggesting the involvement of Foxc2 in the maintenance of SC identity and morphogenesis via interaction with the TM. Single-cell RNA-sequencing analysis revealed that this phenotype is associated with transcriptional changes related to extracellular matrix organization and stiffness in TM cell clusters.
LIFE SCIENCE ALLIANCE
(2023)