Biochemical Mechanism of HIV-1 Resistance to Rilpivirine

Subunit-Selective Mutational Analysis and Tissue Culture Evaluations of the Interactions of the E138K and M184I Mutations in HIV-1 Reverse Transcriptase

(2012) Hong-Tao Xu et al.   JOURNAL OF VIROLOGY

HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism

(2012) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

4′-C-Methyl-2′-Deoxyadenosine and 4′-C-Ethyl-2′-Deoxyadenosine Inhibit HIV-1 Replication

(2011) B. Christie Vu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human Mitochondrial RNA Polymerase: Evaluation of the Single-Nucleotide-Addition Cycle on Synthetic RNA/DNA Scaffolds

(2011) Eric D. Smidansky et al.   BIOCHEMISTRY

Role of Induced Fit in Limiting Discrimination against AZT by HIV Reverse Transcriptase

(2011) Matthew W. Kellinger et al.   BIOCHEMISTRY

The HIV-1 Reverse Transcriptase M184I Mutation Enhances the E138K-Associated Resistance to Rilpivirine and Decreases Viral Fitness

(2011) Rima Kulkarni et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Crystal Structure oftert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket

(2011) Kalyan Das et al.   JOURNAL OF MEDICINAL CHEMISTRY

Compensation by the E138K Mutation in HIV-1 Reverse Transcriptase for Deficits in Viral Replication Capacity and Enzyme Processivity Associated with the M184I/V Mutations

(2011) H.-T. Xu et al.   JOURNAL OF VIROLOGY

Interaction of Reverse Transcriptase (RT) Mutations Conferring Resistance to Lamivudine and Etravirine: Effects on Fitness and RT Activity of Human Immunodeficiency Virus Type 1

(2011) Z. Hu et al.   JOURNAL OF VIROLOGY

Rilpivirine: a step forward in tailored HIV treatment

(2011) Rik Schrijvers et al.   LANCET

Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial

(2011) Calvin J Cohen et al.   LANCET

Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial

(2011) Jean-Michel Molina et al.   LANCET

Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates

(2011) Mark A. Ditzler et al.   NUCLEIC ACIDS RESEARCH

The N348I Mutation at the Connection Subdomain of HIV-1 Reverse Transcriptase Decreases Binding to Nevirapine

(2010) Matthew M. Schuckmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design

(2010) Eric B. Lansdon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase

(2010) Matthew W. Kellinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C

(2010) Hong-Tao Xu et al.   Retrovirology

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

(2010) Kamalendra Singh et al.   Viruses-Basel

Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients

(2009) Atsuko Hachiya et al.   ANTIVIRAL RESEARCH

Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years (1989–2009)

(2009) Marie-Pierre de Béthune   ANTIVIRAL RESEARCH

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase Inhibitor

(2009) Eleftherios Michailidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced dNTP Binding Affinity of 3TC-resistant M184I HIV-1 Reverse Transcriptase Variants Responsible for Viral Infection Failure in Macrophage

(2008) Varuni K Jamburuthugoda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms

(2008) Maryam Ehteshami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

(2008) Stefan G. Sarafianos et al.   JOURNAL OF MOLECULAR BIOLOGY

Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors

(2008) A. Hachiya et al.   JOURNAL OF VIROLOGY

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

(2008) K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Slide into Action: Dynamic Shuttling of HIV Reverse Transcriptase on Nucleic Acid Substrates

(2008) S. Liu et al.   SCIENCE

Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase

(2008) Luis Menéndez-Arias   VIRUS RESEARCH

Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase

(2008) Jingshan Ren et al.   VIRUS RESEARCH

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by the Novel Broad-Range DNA Polymerase InhibitorN-{2-[4-(Aminosulfonyl)phenyl]ethyl}-2-(2-thienyl)acetamide†,‡

(2007) Alon Herschhorn et al.   BIOCHEMISTRY