Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1

Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice

(2015) D. M. Barry et al.   DEVELOPMENT

Single-cell analysis of endothelial morphogenesis in vivo

(2015) J. A. Yu et al.   DEVELOPMENT

Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation

(2015) A. Post et al.   MOLECULAR AND CELLULAR BIOLOGY

IQGAPs choreograph cellular signaling from the membrane to the nucleus

(2015) Jessica M. Smith et al.   TRENDS IN CELL BIOLOGY

IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function

(2014) Hironori Matsunaga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of de novo lumen formation

(2014) Sara Sigurbjörnsdóttir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hematopoietic Stem Cell Cytokines and Fibroblast Growth factor-2 Stimulate Human Endothelial Cell-Pericyte Tube Co-Assembly in 3D Fibrin Matrices under Serum-Free Defined Conditions

(2014) Annie O. Smith et al.   PLoS One

EB1, p150Glued, and Clasp1 control endothelial tubulogenesis through microtubule assembly, acetylation, and apical polarization

(2013) D. J. Kim et al.   BLOOD

Dynamic Regulation of the Cerebral Cavernous Malformation Pathway Controls Vascular Stability and Growth

(2012) Xiangjian Zheng et al.   DEVELOPMENTAL CELL

VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines

(2011) A. N. Stratman et al.   BLOOD

Molecular Mechanisms Controlling Vascular Lumen Formation in Three-Dimensional Extracellular Matrices

(2011) Anastasia Sacharidou et al.   CELLS TISSUES ORGANS

IQGAP1 and its binding proteins control diverse biological functions

(2011) Colin D. White et al.   CELLULAR SIGNALLING

Blood Vessel Tubulogenesis Requires Rasip1 Regulation of GTPase Signaling

(2011) Ke Xu et al.   DEVELOPMENTAL CELL

Endothelial Cell-Pericyte Interactions Stimulate Basement Membrane Matrix Assembly: Influence on Vascular Tube Remodeling, Maturation, and Stabilization

(2011) Amber N. Stratman et al.   MICROSCOPY AND MICROANALYSIS

Tubulogenesis during blood vessel formation

(2011) Ke Xu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events

(2010) A. Sacharidou et al.   BLOOD

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

(2010) Ann C. Zovein et al.   DEVELOPMENTAL CELL

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

(2010) M. G. Lampugnani et al.   JOURNAL OF CELL SCIENCE

Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis

(2010) Mien V. Hoang et al.   MICROVASCULAR RESEARCH

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation

(2009) A. N. Stratman et al.   BLOOD

Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices

(2009) A. N. Stratman et al.   BLOOD

Cellular and Molecular Mechanisms of Vascular Lumen Formation

(2009) M. Luisa Iruela-Arispe et al.   DEVELOPMENTAL CELL

Formation of endothelial lumens requires a coordinated PKC -, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation

(2009) W. Koh et al.   JOURNAL OF CELL SCIENCE

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

(2009) Kevin J Whitehead et al.   NATURE MEDICINE

Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway

(2009) Benjamin Kleaveland et al.   NATURE MEDICINE

Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling

(2008) W. Koh et al.   JOURNAL OF CELL SCIENCE