Engineering nanoparticles to reprogram radiotherapy and immunotherapy: recent advances and future challenges

Selenium‐Containing Nanoparticles Combine the NK Cells Mediated Immunotherapy with Radiotherapy and Chemotherapy

(2020) Shiqian Gao et al.   ADVANCED MATERIALS

Nanoparticle-Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy

(2019) Qian Chen et al.   ADVANCED MATERIALS

Nanoparticle-mediated internal radioisotope therapy to locally increase the tumor vasculature permeability for synergistically improved cancer therapies

(2019) Chao Liang et al.   BIOMATERIALS

Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release

(2019) Shu Lian et al.   EBioMedicine

Redox-Responsive Dual Drug Delivery Nanosystem Suppresses Cancer Repopulation by Abrogating Doxorubicin-Promoted Cancer Stemness, Metastasis, and Drug Resistance

(2019) Jia Liu et al.   Advanced Science

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

(2019) Huitong Ruan et al.   ADVANCED MATERIALS

Overview of recent advances in liposomal nanoparticle-based cancer immunotherapy

(2019) Ang Gao et al.   ACTA PHARMACOLOGICA SINICA

Augment of Oxidative Damage with Enhanced Photodynamic Process and MTH1 Inhibition for Tumor Therapy

(2019) Jing-Jing Hu et al.   NANO LETTERS

Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non–Small Cell Lung Cancer

(2019) Willemijn S. M. E. Theelen et al.   JAMA Oncology

Development of an In Situ Cancer Vaccine via Combinational Radiation and Bacterial‐Membrane‐Coated Nanoparticles

(2019) Ravi B. Patel et al.   ADVANCED MATERIALS

NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2–3, randomised, controlled trial

(2019) Sylvie Bonvalot et al.   LANCET ONCOLOGY

Dual-Blockade Immune Checkpoint for Breast Cancer Treatment Based on a Tumor-Penetrating Peptide Assembling Nanoparticle

(2019) Guorui Li et al.   ACS Applied Materials & Interfaces

Bioactive Polysaccharide Nanoparticles Improve Radiation-Induced Abscopal Effect through Manipulation of Dendritic Cells

(2019) Guibin Pang et al.   ACS Applied Materials & Interfaces

Erythrocyte leveraged chemotherapy (ELeCt): Nanoparticle assembly on erythrocyte surface to combat lung metastasis

(2019) Zongmin Zhao et al.   Science Advances

Diselenide-Pemetrexed Assemblies for Combined Cancer Immuno-, Radio-, and Chemotherapies

(2019) Tianyu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The potentiated checkpoint blockade immunotherapy by ROS-responsive nanocarrier-mediated cascade chemo-photodynamic therapy

(2019) Liqin Hu et al.   BIOMATERIALS

A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy

(2018) Yu Mi et al.   ADVANCED MATERIALS

A Cisplatin-Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for Enhanced Cervical Cancer Therapy

(2018) Na Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hybrid Nanoreactors Enable an Off-the-shelf Strategy for Concurrently Enhanced Chemo-immunotherapy

(2018) Yannan Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoparticle-mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

(2018) Xiaopin Duan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoparticle co-delivery of wortmannin and cisplatin synergistically enhances chemoradiotherapy and reverses platinum resistance in ovarian cancer models

(2018) Maofan Zhang et al.   BIOMATERIALS

Tumor targeted, stealthy and degradable bismuth nanoparticles for enhanced X-ray radiation therapy of breast cancer

(2018) Junjie Deng et al.   BIOMATERIALS

Engineering nanoparticle strategies for effective cancer immunotherapy

(2018) Hong Yeol Yoon et al.   BIOMATERIALS

Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence Following Radiation Therapy in Immunosuppressed Patients

(2018) Marjan Rafat et al.   CANCER RESEARCH

Nanoparticle drug delivery systems: an excellent carrier for tumor peptide vaccines

(2018) Jiemin Wang et al.   DRUG DELIVERY

Co-delivery nanoparticle to overcome metastasis promoted by insufficient chemotherapy

(2018) Qing Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer

(2018) Lina Liu et al.   MOLECULAR THERAPY

mRNA Vaccine with Antigen-Specific Checkpoint Blockade Induces an Enhanced Immune Response against Established Melanoma

(2018) Yuhua Wang et al.   MOLECULAR THERAPY

Cancer Radiosensitizers

(2018) Hao Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

(2018) Yan Liu et al.   Theranostics

Cancer Chemo-Radiotherapy Duo: Nano-Enabled Targeting of DNA Lesion Formation and DNA Damage Response

(2018) Wei Jiang et al.   ACS Applied Materials & Interfaces

Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects

(2018) Lingtong Meng et al.   ACS Nano

Synergistic combination of PEGylated selenium nanoparticles and X-ray-induced radiotherapy for enhanced anticancer effect in human lung carcinoma

(2018) Hejia Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade

(2018) Shanthi Ganesh et al.   MOLECULAR THERAPY

Nanocellulose templated growth of ultra-small bismuth nanoparticles for enhanced radiation therapy

(2018) Li Jiao et al.   Nanoscale

PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug

(2018) Fan Gao et al.   Small

Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion

(2018) Xiaojuan Liu et al.   Cell Reports

The application of nanotechnology in immune checkpoint blockade for cancer treatment

(2018) Huan Deng et al.   JOURNAL OF CONTROLLED RELEASE

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

(2018) Silvia C. Formenti et al.   NATURE MEDICINE

Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response

(2018) Shulei Zhang et al.   CARBOHYDRATE POLYMERS

Polymeric nanoparticles: Promising platform for drug delivery

(2017) Khalid M. El-Say et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Smart Radiation Therapy Biomaterials

(2017) Wilfred Ngwa et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Use of Stereotactic Ablative Radiotherapy (SABR) in Non–Small Cell Lung Cancer Measuring More Than 5 cm

(2017) Hilâl Tekatli et al.   Journal of Thoracic Oncology

A Nano-in-Nano Polymer–Dendrimer Nanoparticle-Based Nanosystem for Controlled Multidrug Delivery

(2017) Zongmin Zhao et al.   MOLECULAR PHARMACEUTICS

Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance–Computed Tomography Image Guided Radiation Therapy

(2017) Alexandre Detappe et al.   NANO LETTERS

Reactive oxygen species generation by copper(II) oxide nanoparticles determined by DNA damage assays and EPR spectroscopy

(2017) Carlos Angelé-Martínez et al.   Nanotoxicology

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

(2017) Yuanzeng Min et al.   Nature Nanotechnology

Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+T cells

(2017) Fiamma Salerno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of particle beam therapy and stereotactic body radiotherapy for early stage non-small cell lung cancer: A systematic review and hypothesis-generating meta-analysis

(2017) Alexander Chi et al.   RADIOTHERAPY AND ONCOLOGY

Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

(2017) Lei Cui et al.   RADIOTHERAPY AND ONCOLOGY

The effects of combined selenium nanoparticles and radiation therapy on breast cancer cells in vitro

(2017) Feng Chen et al.   Artificial Cells Nanomedicine and Biotechnology

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

Facile Synthesis of Uniform-Sized Bismuth Nanoparticles for CT Visualization of Gastrointestinal Tract in Vivo

(2016) Boxiong Wei et al.   ACS Applied Materials & Interfaces

Tumor Angiogenesis Targeted Radiosensitization Therapy Using Gold Nanoprobes Guided by MRI/SPECT Imaging

(2016) Yi Yang et al.   ACS Applied Materials & Interfaces

Hafnium-doped hydroxyapatite nanoparticles with ionizing radiation for lung cancer treatment

(2016) Min-Hua Chen et al.   Acta Biomaterialia

Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

(2016) Guosheng Song et al.   ADVANCED MATERIALS

Perfluorocarbon-Loaded Hollow Bi2Se3Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer

(2016) Guosheng Song et al.   ADVANCED MATERIALS

Nanoparticles in radiation oncology: From bench-side to bedside

(2016) Chloé Rancoule et al.   CANCER LETTERS

Mesenchymal stem cells generate pericytes to promote tumor recurrence via vasculogenesis after stereotactic body radiation therapy

(2016) Huan-Huan Wang et al.   CANCER LETTERS

First-in-Human Study Testing a New Radioenhancer Using Nanoparticles (NBTXR3) Activated by Radiation Therapy in Patients with Locally Advanced Soft Tissue Sarcomas

(2016) Sylvie Bonvalot et al.   CLINICAL CANCER RESEARCH

X-ray-responsive selenium nanoparticles for enhanced cancer chemo-radiotherapy

(2016) Bo Yu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Advanced multimodal nanoparticles delay tumor progression with clinical radiation therapy

(2016) Alexandre Detappe et al.   JOURNAL OF CONTROLLED RELEASE

Highly Integrated Nano-Platform for Breaking the Barrier between Chemotherapy and Immunotherapy

(2016) Di-Wei Zheng et al.   NANO LETTERS

Ultrasound Triggered Tumor Oxygenation with Oxygen-Shuttle Nanoperfluorocarbon to Overcome Hypoxia-Associated Resistance in Cancer Therapies

(2016) Xuejiao Song et al.   NANO LETTERS

Optimising element choice for nanoparticle radiosensitisers

(2016) Stephen J. McMahon et al.   Nanoscale

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

(2016) Danny N. Khalil et al.   Nature Reviews Clinical Oncology

Durable antitumor responses to CD47 blockade require adaptive immune stimulation

(2016) Jonathan T. Sockolosky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

(2016) Qian Chen et al.   Nature Communications

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy

(2016) Marka R. Crittenden et al.   Oncotarget

Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial

(2016) Shady Kotb et al.   Theranostics

Self-Monitoring Artificial Red Cells with Sufficient Oxygen Supply for Enhanced Photodynamic Therapy

(2016) Zhenyu Luo et al.   Scientific Reports

Clearance Pathways and Tumor Targeting of Imaging Nanoparticles

(2015) Mengxiao Yu et al.   ACS Nano

Improving Cancer Chemoradiotherapy Treatment by Dual Controlled Release of Wortmannin and Docetaxel in Polymeric Nanoparticles

(2015) Kin Man Au et al.   ACS Nano

Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

(2015) Ann L. White et al.   CANCER CELL

Nanoparticle–blood interactions: the implications on solid tumour targeting

(2015) James Lazarovits et al.   CHEMICAL COMMUNICATIONS

Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-α and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models

(2015) Nathan A. Koonce et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade

(2015) Elizabeth Buchbinder et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted gold nanoparticles enhance sensitization of prostate tumors to megavoltage radiation therapy in vivo

(2015) Tatiana Wolfe et al.   Nanomedicine-Nanotechnology Biology and Medicine

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

(2015) Eoin F. McKinney et al.   NATURE

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Revealing the Mechanism of the Low-Energy Electron Yield Enhancement from Sensitizing Nanoparticles

(2015) Alexey V. Verkhovtsev et al.   PHYSICAL REVIEW LETTERS

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment

(2015) Claire Vanpouille-Box et al.   VACCINE

Bioorthogonal oxime ligation mediated in vivo cancer targeting

(2015) Li Tang et al.   Chemical Science

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

Alterations of immune response of non-small cell lung cancer with Azacytidine

(2015) John Wrangle et al.   Oncotarget

Rational Design of Cancer-Targeted BSA Protein Nanoparticles as Radiosensitizer to Overcome Cancer Radioresistance

(2014) Yanyu Huang et al.   ACS Applied Materials & Interfaces

Nanoparticle-Delivered Transforming Growth Factor-β siRNA Enhances Vaccination against Advanced Melanoma by Modifying Tumor Microenvironment

(2014) Zhenghong Xu et al.   ACS Nano

Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs

(2014) Thiruganesh Ramasamy et al.   Acta Biomaterialia

The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?

(2014) J. Martin Brown et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells

(2014) Matthew Luchette et al.   Nanomedicine-Nanotechnology Biology and Medicine

Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles

(2014) Peipei Zhang et al.   Nanoscale

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Review of the Botanical Characteristics, Phytochemistry, and Pharmacology ofAstragalus membranaceus(Huangqi)

(2014) Juan Fu et al.   PHYTOTHERAPY RESEARCH

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

(2014) M. M. Martino et al.   SCIENCE

Trial Watch

(2014) Fernando Aranda et al.   OncoImmunology

Gold-Loaded Polymeric Micelles for Computed Tomography-Guided Radiation Therapy Treatment and Radiosensitization

(2013) Ajlan Al Zaki et al.   ACS Nano

Morphologically Virus-Like Fullerenol Nanoparticles Act as the Dual-Functional Nanoadjuvant for HIV-1 Vaccine

(2013) Ligeng Xu et al.   ADVANCED MATERIALS

Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles

(2013) Yanyu Huang et al.   BIOMATERIALS

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

(2013) U. Prabhakar et al.   CANCER RESEARCH

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

The Abscopal Effect Associated With a Systemic Anti-melanoma Immune Response

(2013) Emily F. Stamell et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Targeting by cmHsp70.1-antibody coated and survivin miRNA plasmid loaded nanoparticles to radiosensitize glioblastoma cells

(2013) Sebastian Gaca et al.   JOURNAL OF CONTROLLED RELEASE

Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis

(2013) Zhenghong Xu et al.   JOURNAL OF CONTROLLED RELEASE

Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents

(2013) H Yang et al.   LEUKEMIA

Cisplatin Enhances the Formation of DNA Single- and Double-Strand Breaks by Hydrated Electrons and Hydroxyl Radicals

(2013) Mohammad Rezaee et al.   RADIATION RESEARCH

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

(2013) S. Spranger et al.   Science Translational Medicine

Moderately hypofractionated radiotherapy for localized prostate cancer

(2013) M. Guckenberger et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Nanoparticulate X-ray Computed Tomography Contrast Agents: From Design Validation to in Vivo Applications

(2012) Yanlan Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Blood Compatibility of Iron-Doped Nanosize Hydroxyapatite and Its Drug Release

(2012) V. Sarath Chandra et al.   ACS Applied Materials & Interfaces

Selenium Nanoparticles as a Carrier of 5-Fluorouracil to Achieve Anticancer Synergism

(2012) Wen Liu et al.   ACS Nano

A Selenium-Based Cathode for a High-Voltage Tandem Photoelectrochemical Solar Cell

(2012) Jin Qian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy

(2012) Xiao-Dong Zhang et al.   BIOMATERIALS

pH-Dependent Synthesis and Stability of Aqueous, Elemental Bismuth Glyconanoparticle Colloids: Potentially Biocompatible X-ray Contrast Agents

(2012) Anna L. Brown et al.   CHEMISTRY OF MATERIALS

Nanoscale radiotherapy with hafnium oxide nanoparticles

(2012) Laurence Maggiorella et al.   Future Oncology

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

(2012) Joannes FM Jacobs et al.   LANCET ONCOLOGY

CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria

(2012) M J Barnes et al.   Mucosal Immunology

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

(2012) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis

(2011) Ling Kong et al.   BIOMATERIALS

Improving cancer immunotherapy by targeting tumor-induced immune suppression

(2011) Trina J. Stewart et al.   CANCER AND METASTASIS REVIEWS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma

(2011) Xiang-Yang Wang et al.   EXPERT OPINION ON PHARMACOTHERAPY

How Can We Overcome Tumor Hypoxia in Radiation Therapy?

(2011) Hiroshi HARADA   JOURNAL OF RADIATION RESEARCH

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Role of Gene Methylation in Antitumor Immune Response: Implication for Tumor Progression

(2011) Alfonso Serrano et al.   Cancers

Bacillus Calmette-Guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy

(2010) Jae-Min Yuk et al.   Autophagy

The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy

(2009) Chun-Han Hou et al.   BIOMATERIALS

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

(2009) C Flotho et al.   LEUKEMIA

Selenium in Oncology: From Chemistry to Clinics

(2009) Oliver Micke et al.   MOLECULES

Design considerations for tumour-targeted nanoparticles

(2009) Hak Soo Choi et al.   Nature Nanotechnology

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE