Protein- and Peptide-Based Virus Inactivators: Inactivating Viruses Before Their Entry Into Cells

Detection of Variants With Reduced Baloxavir Marboxil Susceptibility After Treatment of Children With Influenza A During the 2018–2019 Influenza Season

(2020) Masatoki Sato et al.   JOURNAL OF INFECTIOUS DISEASES

Current strategies in extending half-lives of therapeutic proteins

(2019) Rahela Zaman et al.   JOURNAL OF CONTROLLED RELEASE

Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019

(2019) Emi Takashita et al.   Eurosurveillance

Surface plasmon resonance (SPR) reveals direct binding of HSV glycoproteins gH/gL to gD and locates a gH/gL binding site on gD

(2019) Tina M. Cairns et al.   JOURNAL OF VIROLOGY

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine Development

(2019) Ayman Mubarak et al.   Journal of Immunology Research

Soluble Recombinant Hemagglutinin Protein of H1N1pdm09 Influenza Virus Elicits Cross-Protection Against a Lethal H5N1 Challenge in Mice

(2019) Shinya Yamada et al.   Frontiers in Microbiology

Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond

(2018) Shuvam Chaudhuri et al.   ANTIVIRAL RESEARCH

Restricted HIV-1 Env glycan engagement by lectin-reengineered DAVEI protein chimera is sufficient for lytic inactivation of the virus

(2018) Bibek Parajuli et al.   BIOCHEMICAL JOURNAL

Dengue Virus and Its Inhibitors: A Brief Review

(2018) Yu-Shi Tian et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Breach: Host Membrane Penetration and Entry by Nonenveloped Viruses

(2018) Chandra Shekhar Kumar et al.   TRENDS IN MICROBIOLOGY

Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry

(2018) Natalia Cheshenko et al.   PLoS Pathogens

Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement

(2018) Dan Dou et al.   Frontiers in Immunology

Investigational drugs for the treatment of Zika virus infection: a preclinical and clinical update

(2018) Yingshan Han et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The immune response against flaviviruses

(2018) Jose Luis Slon Campos et al.   NATURE IMMUNOLOGY

An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses

(2017) David J. Holthausen et al.   IMMUNITY

Peptides as Therapeutic Agents for Dengue Virus

(2017) Miaw-Fang Chew et al.   International Journal of Medical Sciences

A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

(2017) Yufeng Yu et al.   Nature Communications

HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions

(2017) Qianqian Qi et al.   Emerging Microbes & Infections

Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor

(2017) Alexander Falkenhagen et al.   Molecular Therapy-Nucleic Acids

Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging and re-emerging viruses

(2017) Xiaohuan Wang et al.   Frontiers of Medicine

Visual and Motor Deficits in Grown-up Mice with Congenital Zika Virus Infection

(2017) Liyuan Cui et al.   EBioMedicine

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

(2016) Kelly L. Warfield et al.   ANTIVIRAL RESEARCH

Lytic Inactivation of Human Immunodeficiency Virus by Dual Engagement of gp120 and gp41 Domains in the Virus Env Protein Trimer

(2016) Bibek Parajuli et al.   BIOCHEMISTRY

Heptapeptide ligands against receptor-binding sites of influenza hemagglutinin toward anti-influenza therapy

(2016) Teruhiko Matsubara et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Investigational hemagglutinin-targeted influenza virus inhibitors

(2016) Li-Yan Zeng et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

T cell epitope redundancy: cross-conservation of the TCR face between pathogens and self and its implications for vaccines and autoimmunity

(2016) Leonard Moise et al.   Expert Review of Vaccines

Peptides Derived from Glycoproteins H and B of Herpes Simplex Virus Type 1 and Herpes Simplex Virus Type 2 Are Capable of Blocking Herpetic Infection in vitro

(2016) Abraham Cetina-Corona et al.   INTERVIROLOGY

Regulation of Herpes Simplex Virus Glycoprotein-Induced Cascade of Events Governing Cell-Cell Fusion

(2016) Doina Atanasiu et al.   JOURNAL OF VIROLOGY

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B

(2016) Tzviya Zeev-Ben-Mordehai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Herpesvirus Entry into Host Cells Mediated by Endosomal Low pH

(2016) Anthony V. Nicola   TRAFFIC

Influenza Vaccines: Challenges and Solutions

(2015) Katherine Houser et al.   Cell Host & Microbe

A Peptide Inhibitor Derived from the Conserved Ectodomain Region of DENV Membrane (M) Protein with Activity Against Dengue Virus Infection

(2015) Aussara Panya et al.   Chemical Biology & Drug Design

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41

(2015) Lu Lu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Peptide triazole inactivators of HIV-1: how do they work and what is their potential?

(2015) Irwin Chaiken et al.   Future Medicinal Chemistry

Peptide Triazole Inactivators of HIV-1 Utilize a Conserved Two-Cavity Binding Site at the Junction of the Inner and Outer Domains of Env gp120

(2015) Rachna Aneja et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional Characterization of Glycoprotein H Chimeras Composed of Conserved Domains of the Pseudorabies Virus and Herpes Simplex Virus 1 Homologs

(2015) Sebastian W. Böhm et al.   JOURNAL OF VIROLOGY

Broad-spectrum antivirals against viral fusion

(2015) Frederic Vigant et al.   NATURE REVIEWS MICROBIOLOGY

Viral membrane fusion

(2015) Stephen C. Harrison   VIROLOGY

HIV infection

(2015) Steven G. Deeks et al.   Nature Reviews Disease Primers

Peptide Inhibitors Against Dengue Virus Infection

(2014) Aussara Panya et al.   Chemical Biology & Drug Design

Synergistic Effect Resulting From Combinations of a Bifunctional HIV-1 Antagonist With Antiretroviral Drugs

(2014) Wei Xu et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Mechanism of Multivalent Nanoparticle Encounter with HIV-1 for Potency Enhancement of Peptide Triazole Virus Inactivation

(2014) Arangassery Rosemary Bastian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonmuscle Myosin Heavy Chain IIB Mediates Herpes Simplex Virus 1 Entry

(2014) Jun Arii et al.   JOURNAL OF VIROLOGY

Structural basis for the antibody neutralization ofHerpes simplex virus

(2013) Cheng-Chung Lee et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression

(2013) Natalia Cheshenko et al.   FASEB JOURNAL

A novel gene therapy strategy using secreted multifunctional anti-HIV proteins to confer protection to gene-modified and unmodified target cells

(2013) A Falkenhagen et al.   GENE THERAPY

Inhibition of Dengue Virus Entry into Target Cells Using Synthetic Antiviral Peptides

(2013) Mohammed Abdelfatah Alhoot et al.   International Journal of Medical Sciences

Peptide inhibitors against herpes simplex virus infections

(2013) Stefania Galdiero et al.   JOURNAL OF PEPTIDE SCIENCE

Displacement of the C Terminus of Herpes Simplex Virus gD Is Sufficient To Expose the Fusion-Activating Interfaces on gD

(2013) John R. Gallagher et al.   JOURNAL OF VIROLOGY

Exceptionally Potent and Broadly Cross-Reactive, Bispecific Multivalent HIV-1 Inhibitors Based on Single Human CD4 and Antibody Domains

(2013) W. Chen et al.   JOURNAL OF VIROLOGY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions

(2013) Arangassery Bastian et al.   Retrovirology

Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin

(2013) Jie Yang et al.   Viruses-Basel

Concepts of papillomavirus entry into host cells

(2013) Patricia M. Day et al.   Current Opinion in Virology

HIV takes double hit before entry

(2012) Rogier W Sanders   BMC BIOLOGY

Theoretical Investigation on the Binding Specificity of Sialyldisaccharides with Hemagglutinins of Influenza A Virus by Molecular Dynamics Simulations

(2012) Thanu R. K. Priyadarzini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a Dengue Virus Envelope Protein Late-Stage Fusion Intermediate

(2012) D. E. Klein et al.   JOURNAL OF VIROLOGY

Antimicrobial Peptides for Therapeutic Applications: A Review

(2012) Min-Duk Seo et al.   MOLECULES

Cross-neutralization of influenza A viruses mediated by a single antibody loop

(2012) Damian C. Ekiert et al.   NATURE

Cryo-EM structure of the mature dengue virus at 3.5-Å resolution

(2012) Xiaokang Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Release of Dengue Virus Genome Induced by a Peptide Inhibitor

(2012) Shee-Mei Lok et al.   PLoS One

A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

(2012) Lu Lu et al.   Retrovirology

Herpes Virus Fusion and Entry: A Story with Many Characters

(2012) Roselyn J. Eisenberg et al.   Viruses-Basel

Pathogenic Mechanisms of HIV Disease

(2011) Susan Moir et al.   Annual Review of Pathology-Mechanisms of Disease

Cell-Free HIV-1 Virucidal Action by Modified Peptide Triazole Inhibitors of Env gp120

(2011) Arangassery R. Bastian et al.   ChemMedChem

Engineered Single Human CD4 Domains as Potent HIV-1 Inhibitors and Components of Vaccine Immunogens

(2011) W. Chen et al.   JOURNAL OF VIROLOGY

Secreted Antiviral Entry Inhibitory (SAVE) Peptides for Gene Therapy of HIV Infection

(2011) Lisa Egerer et al.   MOLECULAR THERAPY

Fusing structure and function: a structural view of the herpesvirus entry machinery

(2011) Sarah A. Connolly et al.   NATURE REVIEWS MICROBIOLOGY

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin

(2011) J. R. R. Whittle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1

(2011) Paolo Di Giovine et al.   PLoS Pathogens

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialic Acid-Mimic Peptides As Hemagglutinin Inhibitors for Anti-Influenza Therapy

(2010) Teruhiko Matsubara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem

(2010) A. G. Schmidt et al.   JOURNAL OF VIROLOGY

Recombinant Soluble, Multimeric HA and NA Exhibit Distinctive Types of Protection against Pandemic Swine-Origin 2009 A(H1N1) Influenza Virus Infection in Ferrets

(2010) B. J. Bosch et al.   JOURNAL OF VIROLOGY

Cascade of Events Governing Cell-Cell Fusion Induced by Herpes Simplex Virus Glycoproteins gD, gH/gL, and gB

(2010) D. Atanasiu et al.   JOURNAL OF VIROLOGY

Bimolecular Complementation Defines Functional Regions of Herpes Simplex Virus gB That Are Involved with gH/gL as a Necessary Step Leading to Cell Fusion

(2010) D. Atanasiu et al.   JOURNAL OF VIROLOGY

Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1

(2010) Jun Arii et al.   NATURE

Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL

(2010) Tirumala K Chowdary et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Optimization and De Novo Design of Dengue Virus Entry Inhibitory Peptides

(2010) Joshua M. Costin et al.   PLoS Neglected Tropical Diseases

Peptide Inhibitors of Dengue-Virus Entry Target a Late-Stage Fusion Intermediate

(2010) Aaron G. Schmidt et al.   PLoS Pathogens

T cell epitope: Friend or Foe? Immunogenicity of biologics in context☆

(2009) Constanze A. Weber et al.   ADVANCED DRUG DELIVERY REVIEWS

Combinations of the First and Next Generations of Human Immunodeficiency Virus (HIV) Fusion Inhibitors Exhibit a Highly Potent Synergistic Effect against Enfuvirtide- Sensitive and -Resistant HIV Type 1 Strains

(2009) C. Pan et al.   JOURNAL OF VIROLOGY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses

(2009) T. Suenaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Soluble CD4 and CD4-Mimetic Compounds Inhibit HIV-1 Infection by Induction of a Short-Lived Activated State

(2009) Hillel Haim et al.   PLoS Pathogens

Multiple Peptides Homologous to Herpes Simplex Virus Type 1 Glycoprotein B Inhibit Viral Infection

(2008) R. Akkarawongsa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The order Herpesvirales

(2008) Andrew J. Davison et al.   ARCHIVES OF VIROLOGY

Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

(2008) A. S. De Groot et al.   BLOOD

PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B

(2008) Takeshi Satoh et al.   CELL

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE

Viral membrane fusion

(2008) Stephen C Harrison   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers

(2008) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm

(2008) Gregory B Melikyan   Retrovirology

The Flavivirus Precursor Membrane-Envelope Protein Complex: Structure and Maturation

(2008) L. Li et al.   SCIENCE

Characterization of the interaction of domain III of the envelope protein of dengue virus with putative receptors from CHO cells

(2008) Vivian Huerta et al.   VIRUS RESEARCH