Exceptionally Potent and Broadly Cross-Reactive, Bispecific Multivalent HIV-1 Inhibitors Based on Single Human CD4 and Antibody Domains

Antibody-based candidate therapeutics against HIV-1: implications for virus eradication and vaccine design

(2013) Weizao Chen et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

(2013) Priyamvada Acharya et al.   STRUCTURE

Catching HIV ‘in the act’ with 3D electron microscopy

(2013) Lesley A. Earl et al.   TRENDS IN MICROBIOLOGY

Evidence for a Continuous Drift of the HIV-1 Species towards Higher Resistance to Neutralizing Antibodies over the Course of the Epidemic

(2013) Mélanie Bouvin-Pley et al.   PLoS Pathogens

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

Engineered T cells for anti-cancer therapy

(2012) Cameron J Turtle et al.   CURRENT OPINION IN IMMUNOLOGY

Broad Antiviral Activity and Crystal Structure of HIV-1 Fusion Inhibitor Sifuvirtide

(2012) Xue Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Monoclonal Antibodies Targeting Nonoverlapping Epitopes on Insulin-like Growth Factor II as a Novel Type of Candidate Cancer Therapeutics

(2012) W. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4

(2012) Y. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated selection of stabilizing mutations in designed and natural proteins

(2012) B. Borgo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Cell Transmission Enables HIV-1 to Evade Inhibition by Potent CD4bs Directed Antibodies

(2012) Irene A. Abela et al.   PLoS Pathogens

Bispecific antibodies engage T cells for antitumor immunotherapy

(2011) Bryan D Choi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Genetic and Neutralization Sensitivity of Diverse HIV-1envClones from Chronically Infected Patients in China

(2011) Hong Shang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered Single Human CD4 Domains as Potent HIV-1 Inhibitors and Components of Vaccine Immunogens

(2011) W. Chen et al.   JOURNAL OF VIROLOGY

Activity of Broadly Neutralizing Antibodies, Including PG9, PG16, and VRC01, against Recently Transmitted Subtype B HIV-1 Variants from Early and Late in the Epidemic

(2011) Z. Euler et al.   JOURNAL OF VIROLOGY

A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity

(2011) Yang Feng et al.   ARTHRITIS RESEARCH & THERAPY

Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates

(2010) Weizao Chen et al.   ANTIVIRAL RESEARCH

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

(2010) X. Wu et al.   SCIENCE

Replication competent molecular clones of HIV-1 expressing Renilla luciferase facilitate the analysis of antibody inhibition in PBMC

(2010) Tara G. Edmonds et al.   VIROLOGY

Engineered Human Antibody Constant Domains with Increased Stability

(2009) Rui Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A large human domain antibody library combining heavy and light chain CDR3 diversity

(2009) Weizao Chen et al.   MOLECULAR IMMUNOLOGY

Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target

(2009) L. M. Walker et al.   SCIENCE

Exceptionally Potent Cross‐Reactive Neutralization of Nipah and Hendra Viruses by a Human Monoclonal Antibody

(2008) Zhongyu Zhu et al.   JOURNAL OF INFECTIOUS DISEASES

Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

(2008) François Stricher et al.   JOURNAL OF MOLECULAR BIOLOGY

Construction of a Large Phage-Displayed Human Antibody Domain Library with a Scaffold Based On a Newly Identified Highly Soluble, Stable Heavy Chain Variable Domain

(2008) Weizao Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers

(2008) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-clade neutralization patterns among HIV-1 strains from the six major clades of the pandemic evaluated and compared in two different models

(2008) Bruce K. Brown et al.   VIROLOGY

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY

Cavities and Atomic Packing in Protein Structures and Interfaces

(2008) Shrihari Sonavane et al.   PLoS Computational Biology