Potential Antifungal Targets Based on Glucose Metabolism Pathways of Candida albicans

Nutrient and Stress Sensing in Pathogenic Yeasts

(2019) Julian C. Rutherford et al.   Frontiers in Microbiology

Hexokinase and Glucokinases Are Essential for Fitness and Virulence in the Pathogenic Yeast Candida albicans

(2019) Romain Laurian et al.   Frontiers in Microbiology

Sugar Sensing and Signaling in Candida albicans and Candida glabrata

(2019) Mieke Van Ende et al.   Frontiers in Microbiology

Monoterpenoid perillyl alcohol impairs metabolic flexibility of Candida albicans by inhibiting glyoxylate cycle

(2018) Moiz A. Ansari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functions of CaPhm7 in the regulation of ion homeostasis, drug tolerance, filamentation and virulence in Candida albicans

(2018) Linghuo Jiang et al.   BMC MICROBIOLOGY

Targeting FBPase is an emerging novel approach for cancer therapy

(2018) Gao-Min Liu et al.   Cancer Cell International

Antifungal activity of magnoflorine against Candida strains

(2018) Jaegoo Kim et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Further investigation of inhibitors of MRSA pyruvate kinase: Towards the conception of novel antimicrobial agents

(2017) Christophe Labrière et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fructose-1,6-bisphosphatase inhibitors: A new valid approach for management of type 2 diabetes mellitus

(2017) Ramandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Rational Design of Novel Inhibitors Against Fructose-1,6-Bisphosphate Aldolase from Candida albicans

(2017) Xinya Han et al.   Journal of Chemical Information and Modeling

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development

(2017) Arsa Thammahong et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Epidemiology, species distribution, clinical characteristics and mortality of candidaemia in a tertiary care university hospital in Turkey, 2007-2014

(2017) Ayşegül Yeşilkaya et al.   MYCOSES

Candida albicans Heat Shock Proteins and Hsps-Associated Signaling Pathways as Potential Antifungal Targets

(2017) Ying Gong et al.   Frontiers in Cellular and Infection Microbiology

Trehalose-6-Phosphate as a Potential Lead Candidate for the Development of Tps1 Inhibitors: Insights from the Trehalose Biosynthesis Pathway in Diverse Yeast Species

(2016) Rayne S. S. Magalhães et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Synthesis and biological activity of novel ester derivatives of N3-(4-metoxyfumaroyl)-(S)-2,3-diaminopropanoic acid containing amide and keto function as inhibitors of glucosamine-6-phosphate synthase

(2016) Dorota Pawlak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alkaloids as Inhibitors of Malate Synthase from Paracoccidioides spp.: Receptor-Ligand Interaction-Based Virtual Screening and Molecular Docking Studies, Antifungal Activity, and the Adhesion Process

(2015) Fausto Guimaraes Costa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis, anticandidal activity of N3-(4-methoxyfumaroyl)-(S)-2,3-diaminopropanoic amide derivatives – Novel inhibitors of glucosamine-6-phosphate synthase

(2015) Dorota Pawlak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Medically important fungi respond to azole drugs: an update

(2015) Martin Zavrel et al.   Future Microbiology

Mohangamides A and B, New Dilactone-Tethered Pseudo-Dimeric Peptides Inhibiting Candida albicans Isocitrate Lyase

(2015) Munhyung Bae et al.   ORGANIC LETTERS

The calcineurin inhibitor cyclosporin A exhibits synergism with antifungals against Candida parapsilosis species complex

(2014) R. d. A. Cordeiro et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Serum Antibody Signature Directed against Candida albicans Hsp90 and Enolase Detects Invasive Candidiasis in Non-Neutropenic Patients

(2014) Aida Pitarch et al.   JOURNAL OF PROTEOME RESEARCH

In Candida parapsilosis the ATC1 Gene Encodes for an Acid Trehalase Involved in Trehalose Hydrolysis, Stress Resistance and Virulence

(2014) Ruth Sánchez-Fresneda et al.   PLoS One

Inhibitors of the Glyoxylate Cycle Enzyme ICL1 in Candida albicans for Potential Use as Antifungal Agents

(2014) Hong-Leong Cheah et al.   PLoS One

Antifungal drug resistance mechanisms in pathogenic fungi: from bench to bedside

(2013) M. Cuenca-Estrella   CLINICAL MICROBIOLOGY AND INFECTION

Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence

(2013) Hui-Ching Ko et al.   JOURNAL OF MICROBIOLOGY

Hsp21 Potentiates Antifungal Drug Tolerance in Candida albicans

(2013) François L. Mayer et al.   PLoS One

Carbon Catabolite Control in Candida albicans: New Wrinkles in Metabolism

(2013) M. C. Lorenz   mBio

Tight Control of Trehalose Content Is Required for Efficient Heat-induced Cell Elongation inCandida albicans

(2012) Joke Serneels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of metal-chelating inhibitors for the Class II fructose 1,6-bisphosphate (FBP) aldolase

(2012) Geneviève Labbé et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Small but Crucial: The Novel Small Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in Candida albicans

(2012) François L. Mayer et al.   PLoS One

Efficacy of Oral E1210, a New Broad-Spectrum Antifungal with a Novel Mechanism of Action, in Murine Models of Candidiasis, Aspergillosis, and Fusariosis

(2011) Katsura Hata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphoenolpyruvate Carboxykinase as the Sole Anaplerotic Enzyme in Saccharomyces cerevisiae

(2010) R. M. Zelle et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Intracellular Acetyl Unit Transport in Fungal Carbon Metabolism

(2010) Karin Strijbis et al.   EUKARYOTIC CELL

Rational Design, Synthesis, and Evaluation of New Selective Inhibitors of Microbial Class II (Zinc Dependent) Fructose Bis-phosphate Aldolases

(2010) Racha Daher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of trehalose-6P phosphatase (TPS2) in stress tolerance and resistance to macrophage killing in Candida albicans

(2009) María Martínez-Esparza et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans

(2009) Christopher Askew et al.   PLoS Pathogens

Structural and kinetic differences between human andAspergillus fumigatusD-glucosamine-6-phosphateN-acetyltransferase

(2008) Ramon Hurtado-Guerrero et al.   BIOCHEMICAL JOURNAL

Combined Inactivation of the Candida albicans GPR1 and TPS2 Genes Results in Avirulence in a Mouse Model for Systemic Infection

(2008) M. M. Maidan et al.   INFECTION AND IMMUNITY