A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle

Divergent Cl-and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

(2020) Lilia Leisle et al.   eLife

Adaptive Partitioning QM/MM for Molecular Dynamics Simulations: 6. Proton Transport through a Biological Channel

(2019) Adam W. Duster et al.   Journal of Chemical Theory and Computation

Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl−/H+ antiporter

(2019) Kunwoong Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of CLCNKB mutations at dimer‐interface, calcium‐binding site, and pore reveals a variety of functional alterations in ClC‐Kb channel leading to Bartter syndrome

(2019) Yohan Bignon et al.   HUMAN MUTATION

Multiscale Kinetic Modeling Reveals an Ensemble of Cl–/H+ Exchange Pathways in ClC-ec1 Antiporter

(2018) Heather B. Mayes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A CLC-type F-/H+ antiporter in ion-swapped conformations

(2018) Nicholas B. Last et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease

(2018) Thomas J. Jentsch et al.   PHYSIOLOGICAL REVIEWS

A CLC-type F-/H+ antiporter in ion-swapped conformations

(2018) Nicholas B. Last et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the CLC-1 chloride channel from Homo sapiens

(2018) Eunyong Park et al.   eLife

Confidence Analysis of DEER Data and Its Structural Interpretation with Ensemble-Biased Metadynamics

(2018) Eric J. Hustedt et al.   BIOPHYSICAL JOURNAL

Modulating the Chemical Transport Properties of a Transmembrane Antiporter via Alternative Anion Flux

(2018) Zhi Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Basis for Differential Anion Binding and Proton Coupling in the Cl–/H+ Exchanger ClC-ec1

(2016) Tao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Revealing an outward-facing open conformational state in a CLC Cl–/H+ exchange transporter

(2016) Chandra M Khantwal et al.   eLife

Structural Symmetry in Membrane Proteins

(2015) Lucy R. Forrest   Annual Review of Biophysics

13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1

(2015) Sherwin J. Abraham et al.   JOURNAL OF BIOMOLECULAR NMR

Structure and gating of CLC channels and exchangers

(2015) Alessio Accardi   JOURNAL OF PHYSIOLOGY-LONDON

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

(2015) H Hu et al.   MOLECULAR PSYCHIATRY

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters

(2015) Daniel Basilio et al.   Jove-Journal of Visualized Experiments

Dipole Moment and Binding Energy of Water in Proteins from Crystallographic Analysis

(2014) A. Morozenko et al.   Journal of Chemical Theory and Computation

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Conformational changes required for H+/Cl− exchange mediated by a CLC transporter

(2014) Daniel Basilio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

(2014) Smriti Mishra et al.   eLife

Exome sequencing reveals new causal mutations in children with epileptic encephalopathies

(2013) Krishna R. Veeramah et al.   EPILEPSIA

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Water access points and hydration pathways in CLC H+/Cl−transporters

(2013) Wei Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

INVERTED TOPOLOGIES IN MEMBRANE PROTEINS: A MINI-REVIEW

(2013) Amanda M Duran et al.   Computational and Structural Biotechnology Journal

DEER Distance Measurements on Proteins

(2012) Gunnar Jeschke   Annual Review of Physical Chemistry

Surprises from an Unusual CLC Homolog

(2012) Sabrina Phillips et al.   BIOPHYSICAL JOURNAL

The global analysis of DEER data

(2012) Suzanne Brandon et al.   JOURNAL OF MAGNETIC RESONANCE

Improved Sensitivity for Long-Distance Measurements in Biomolecules: Five-Pulse Double Electron–Electron Resonance

(2012) Peter P. Borbat et al.   Journal of Physical Chemistry Letters

Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H+/Cl− exchanger

(2012) Alessandra Picollo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters

(2012) L. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoride resistance and transport by riboswitch-controlled CLC antiporters

(2012) R. B. Stockbridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Proton Access in a Cl−/H+ Antiporter

(2012) Hyun-Ho Lim et al.   PLOS BIOLOGY

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

(2012) Eva Chovancova et al.   PLoS Computational Biology

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ClC-7 is a slowly voltage-gated 2Cl−/1H+-exchanger and requires Ostm1 for transport activity

(2011) Lilia Leisle et al.   EMBO JOURNAL

Physiology and Pathophysiology of CLC-1: Mechanisms of a Chloride Channel Disease, Myotonia

(2011) Chih-Yung Tang et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

The Alternating-Access Mechanism of MFS Transporters Arises from Inverted-Topology Repeats

(2011) Sebastian Radestock et al.   JOURNAL OF MOLECULAR BIOLOGY

ClC-5 mutations associated with Dent’s disease: a major role of the dimer interface

(2011) Stéphane Lourdel et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Graphical analysis of pH-dependent properties of proteins predicted using PROPKA

(2011) Michał Rostkowski et al.   BMC STRUCTURAL BIOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The structural basis of secondary active transport mechanisms

(2010) Lucy R. Forrest et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Secondary Water Pore Formation for Proton Transport in a ClC Exchanger Revealed by an Atomistic Molecular-Dynamics Simulation

(2010) Youn Jo Ko et al.   BIOPHYSICAL JOURNAL

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Design, function and structure of a monomeric ClC transporter

(2010) Janice L. Robertson et al.   NATURE

Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle

(2010) Liang Feng et al.   SCIENCE

Proton Transport Pathway in the ClC Cl−/H+ Antiporter

(2009) Dong Wang et al.   BIOPHYSICAL JOURNAL

Substrate-driven conformational changes in ClC-ec1 observed by fluorine NMR

(2009) Shelley M Elvington et al.   EMBO JOURNAL

Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism

(2009) Ferdinando Palmieri et al.   FEBS LETTERS

Intracellular Proton-Transfer Mutants in a CLC Cl−/H+Exchanger

(2009) Hyun-Ho Lim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Crystallizing membrane proteins using lipidic mesophases

(2009) Martin Caffrey et al.   Nature Protocols

Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters

(2009) Alessandra Picollo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Rocking Bundle: A Mechanism for Ion-Coupled Solute Flux by Symmetrical Transporters

(2009) Lucy R. Forrest et al.   PHYSIOLOGY

Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats

(2009) T. J. Crisman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the ClC-4 Transport Mechanism from Studies of Zn2+ Inhibition

(2008) Jeremiah D. Osteen et al.   BIOPHYSICAL JOURNAL

Chronic renal failure in a boy with classic Bartter’s syndrome due to a novel mutation in CLCNKB coding for the chloride channel

(2008) Chien-Ming Lin et al.   EUROPEAN JOURNAL OF PEDIATRICS

The ClC-0 chloride channel is a 'broken' Cl−/H+ antiporter

(2008) Jiří Lísal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A provisional transport mechanism for a chloride channel-type Cl-/H+ exchanger

(2008) C. Miller et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mechanism for alternating access in neurotransmitter transporters

(2008) L. R. Forrest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA