Article
Biochemistry & Molecular Biology
Nadav Yayon, Oren Amsalem, Tamara Zorbaz, Or Yakov, Serafima Dubnov, Katarzyna Winek, Amir Dudai, Gil Adam, Anna K. Schmidtner, Marc Tessier-Lavigne, Nicolas Renier, Naomi Habib, Idan Segev, Michael London, Hermona Soreq
Summary: This study investigated the morphology and transcriptional diversity of cortical cholinergic VIP/ChAT interneurons (VChIs) and identified two distinct morphological types. After whisker deprivation, changes in dendritic arborization, cortical depth, and distribution patterns were observed in the barrel fields. The researchers also discovered key regulatory factors involved in morphological changes using a method for isolating nuclei from fixed tissues.
Article
Biology
Christina Georgiou, Vassilis Kehayas, Kok Sin Lee, Federico Brandalise, Daniela A. Sahlender, Jerome Blanc, Graham Knott, Anthony Holtmaat
Summary: This study identifies a subset of superficial multipolar inhibitory interneurons expressing VIP with high dynamics, located in layer 1 of the cortex, and exhibiting the electrophysiological characteristics of bursting cells. The structural plasticity of these neurons is distinct from that of excitatory neurons.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Arquimedes Cheffer, Marta Garcia-Miralles, Esther Maier, Ipek Akol, Henriette Franz, Vandana Shree Vedartham Srinivasan, Tanja Vogel
Summary: This study reveals that DOT1L plays a crucial role in the development of inhibitory neurons in the cortex, with its deletion resulting in a decrease in GABAergic interneuron numbers and altered distribution in the cortex.
Article
Cell Biology
Heng Kang Yao, Alexandre Guet-McCreight, Frank Mazza, Homeira Moradi Chameh, Thomas D. Prevot, John D. Griffiths, Shreejoy J. Tripathy, Taufik A. Valiante, Etienne Sibille, Etay Hay
Summary: This study investigated the impact of reduced somatostatin interneuron-mediated inhibition on cortical processing in human neuronal microcircuits using a data-driven computational approach. The findings demonstrate a decreased signal-to-noise ratio and increased false detection of stimuli in depression due to higher baseline activity. Ultimately, this research provides mechanistic insights into how reduced inhibition impairs cortical processing in depression and its quantitative links to cognitive deficits.
Article
Physiology
Jing Wu, Penglai Liu, Xingfeng Mao, Fang Qiu, Ling Gong, Jinyun Wu, Dejuan Wang, Miao He, Anan Li
Summary: VIP+ miRNAs are important factors in sensory processing, affecting olfactory function and olfactory neural activity.
Article
Biochemistry & Molecular Biology
Jinyun Wu, Zhirong Zhao, Yun Shi, Miao He
Summary: Different classes of interneurons in the cortex exhibit distinct laminar distribution patterns, contributing to the organization of cortical microcircuits. This study focused on VIP+ interneurons and uncovered significant laminar differences in their transcriptomic profiles. Upper layer and deeper layer VIP+ interneurons were found to be transcriptionally distinct, with differential expression of genes involved in synapse organization and regulation of membrane potential. The findings also identified potential marker genes for upper layer VIP+ interneurons in different cortical regions, including Tac2 and CxCl14.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yuanlei Yue, Ryan T. Ash, Natalie Boyle, Anna Kinter, Yipeng Li, Chen Zeng, Hui Lu
Summary: Mutation in the MECP2 gene causes Rett syndrome and loss of motor function. A study on mouse models revealed changes in circuit function in the motor cortex, which could be potential biomarkers for motor regression in Rett syndrome.
Review
Biochemistry & Molecular Biology
Ainhoa Pascual-Alonso, Antonio F. Martinez-Monseny, Clara Xiol, Judith Armstrong
Summary: Mutations in the MECP2 gene can lead to Rett syndrome, primarily affecting females, while males can have a wide range of clinical presentations. In addition, there are unknown variants in MECP2 that complicate diagnosis. Unlike RTT, MECP2 duplication syndrome predominantly affects males and is usually inherited from the mother.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Renata Batista-Brito, Antara Majumdar, Alejandro Nuno, Claire Ward, Clayton Barnes, Kasra Nikouei, Martin Vinck, Jessica A. Cardin
Summary: GABAergic inhibition is crucial in cortical circuit development. Neuregulin 1 (Nrg1) and its receptor ErbB4 play a key role in the maturation and synaptic connectivity of interneurons. Conditional deletion of ErbB4 in parvalbumin-expressing (PV) interneurons in mice results in alterations in the activity of cortical neurons and disruption of cortical temporal organization. It also leads to dysregulation of excitatory pyramidal neuron dendritic architecture and a redistribution of spine density. These findings highlight the importance of early developmental Nrg1/ErbB4 signaling in the maturation of cortical circuits.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Felix Leroy, Christopher A. de Solis, Lara M. Boyle, Tobias Bock, Olivia M. Lofaro, Eric W. Buss, Arun Asok, Eric R. Kandel, Steven A. Siegelbaum
Summary: Studies have shown that VIP-expressing interneurons participate in social memory storage by enhancing information transfer and causing long-term depression through release of enkephalin. Additionally, VIP neuron activity in the CA2 region increases selectively during exploration of a novel conspecific.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Ioana Genescu, Sonia Garel
Summary: The functioning of the neocortex relies on a complex architecture of circuits, with an important entry point located in the superficial layer 1 (L1) containing inputs and inhibitory interneurons. While evidence suggests L1 plays important physiological roles, understanding of its wiring during development remains limited.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Koun Onodera, Hiroyuki K. Kato
Summary: The authors demonstrate that translaminar feedback projections from layer 5 suppress activity in superficial layers and enhance feature selectivity in the primary auditory cortex.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Weiyi Hu, Yan Zhang, Dali Wang, Tingting Yang, Jiajia Qi, Yonghong Zhang, Hao Jiang, Jiabao Zhang, Boxing Sun, Shuang Liang
Summary: Research indicates that iron overload-induced ferroptosis impairs porcine oocyte meiosis and decreases oocyte quality by increasing oxidative stress, inducing mitochondrial dysfunction, and triggering autophagy, ultimately leading to inhibited meiotic process and reduced embryonic developmental competence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Amir Dudai, Nadav Yayon, Hermona Soreq, Michael London
Summary: The urgent task of neuroscience is to understand how neuronal circuits operate, what causes them to fail, and how they can be repaired. This review focuses on a specific type of cortical neurons marked by the expression of VIP and ChAT, which can release both GABA and ACh. Despite their sparse population, these neurons may have a significant impact on cortical circuit function.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Donald A. Wilson, G. Fleming, C. R. O. Williams, C. M. Teixeira, J. F. Smiley, Mariko Saito
Summary: This study aimed to investigate the effects of optogenetic manipulation on the neocortex of adult mice after early ethanol exposure. The results showed that in mice exposed to ethanol, optical stimulation of prefrontal cortex SST neurons failed to evoke slow-wave potentials and long-latency single-unit excitation, while this effect was observed in saline-treated mice. These findings suggest that SST neurons may contribute to slow-wave sleep impairment after developmental ethanol exposure.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Martin Vinck, Renata Batista-Brito, Ulf Knoblich, Jessica A. Cardin
Review
Neurosciences
Matthew J. McGinley, Martin Vinck, Jacob Reimer, Renata Batista-Brito, Edward Zagha, Cathryn R. Cadwell, Andreas S. Tolias, Jessica A. Cardin, David A. McCormick
Article
Neurosciences
Renata Batista-Brito, Martin Vinck, Katie A. Ferguson, Jeremy T. Chang, David Laubender, Gyorgy Lur, James M. Mossner, Victoria G. Hernandez, Charu Ramakrishnan, Karl Deisseroth, Michael J. Higley, Jessica A. Cardin
Article
Neurosciences
Sebnem N. Tuncdemir, Gord Fishell, Renata Batista-Brito
Article
Neurosciences
Renata Batista-Brito, Edward Zagha, Check For Jacob M. Ratliff, Martin Vinck
CURRENT OPINION IN NEUROBIOLOGY
(2018)
Article
Neurosciences
Renata Batista-Brito, Jennie Close, Robert Machold, Gord Fishell
JOURNAL OF NEUROSCIENCE
(2008)
Article
Neurosciences
Jennie Close, Han Xu, Natalia De Marco Garcia, Renata Batista-Brito, Elsa Rossignol, Bernardo Rudy, Gord Fishell
JOURNAL OF NEUROSCIENCE
(2012)
Article
Multidisciplinary Sciences
Christian Mayer, Christoph Hafemeister, Rachel C. Bandler, Robert Machold, Renata Batista Brito, Xavier Jaglin, Kathryn Allaway, Andrew Butler, Gord Fishell, Rahul Satija
Article
Neurosciences
Renata Batista-Brito, Elsa Rossignol, Jens Hjerling-Leffler, Myrto Denaxa, Michael Wegner, Veronique Lefebvre, Vassilis Pachnis, Gord Fishell
Article
Neurosciences
Michel Aime Picardo, Philippe Guigue, Paolo Bonifazi, Renata Batista-Brito, Camille Allene, Alain Ribas, Gord Fishell, Agnes Baude, Rosa Cossart
Article
Neurosciences
Xavier H. Jaglin, Jens Hjerling-Leffler, Gord Fishell, Renata Batista-Brito
FRONTIERS IN NEURAL CIRCUITS
(2012)
Editorial Material
Neurosciences
Renata Batista-Brito, Gord Fishell
Article
Neurosciences
Douglas Vormstein-Schneider, Jessica D. Lin, Kenneth A. Pelkey, Ramesh Chittajallu, Baolin Guo, Mario A. Arias-Garcia, Kathryn Allaway, Sofia Sakopoulos, Gates Schneider, Olivia Stevenson, Josselyn Vergara, Jitendra Sharma, Qiangge Zhang, Tom P. Franken, Jared Smith, Leena A. Ibrahim, Kevin J. M. Astro, Ehsan Sabri, Shuhan Huang, Emilia Favuzzi, Timothy Burbridge, Qing Xu, Lihua Guo, Ian Vogel, Vanessa Sanchez, Giuseppe A. Saldi, Bram L. Gorissen, Xiaoqing Yuan, Kareem A. Zaghloul, Orrin Devinsky, Bernardo L. Sabatini, Renata Batista-Brito, John Reynolds, Guoping Feng, Zhanyan Fu, Chris J. McBain, Gord Fishell, Jordane Dimidschstein
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Hermany Munguba, Bidisha Chattopadhyaya, Stephan Nilsson, Josianne N. Carrico, Fatima Memic, Polina Oberst, Renata Batista-Brito, Ana Belen Munoz-Manchado, Michael Wegner, Gordon Fishell, Graziella Di Cristo, Jens Hjerling-Leffler
Summary: Pvalb(+) neurons provide robust inhibition to neighboring pyramidal neurons and undergo extensive synaptic formation and maturation during the first weeks after birth and continue to dynamically maintain their synaptic output throughout adulthood. Sox6 plays a crucial role in the postnatal maturation and synaptic function of cortical Pvalb(+) neurons, with its loss leading to synaptic bouton growth failure and shrinkage of established boutons. These findings suggest a constitutive role for Sox6 in maintaining synaptic output from Pvalb(+) neurons into adulthood.
JOURNAL OF NEUROSCIENCE
(2021)
