A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses

Immune system development varies according to age, location, and anemia in African children

(2020) Danika L. Hill et al.   Science Translational Medicine

Dysfunctional peripheral T follicular helper cells dominate in people with impaired influenza vaccine responses: Results from the FLORAH study

(2019) Suresh Pallikkuth et al.   PLOS BIOLOGY

Searching for the origin of the enigmatic circulating T follicular helper cells

(2019) Savita Pahwa   JOURNAL OF CLINICAL INVESTIGATION

T follicular helper cells in human efferent lymph retain lymphoid characteristics

(2019) Laura A. Vella et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of B Cell Memory in Malaria

(2019) Ann Ly et al.   Frontiers in Immunology

Altered immune cell follicular dynamics in HIV infection following influenza vaccination

(2018) Eirini Moysi et al.   JOURNAL OF CLINICAL INVESTIGATION

Persistence of Long-lived Memory B Cells specific to Duffy Binding Protein in individuals exposed to Plasmodium vivax

(2018) Siriruk Changrob et al.   Scientific Reports

CXCR3+ T Follicular Helper Cells Induced by Co-Administration of RTS,S/AS01B and Viral-Vectored Vaccines Are Associated With Reduced Immunogenicity and Efficacy Against Malaria

(2018) Georgina Bowyer et al.   Frontiers in Immunology

Emerging concepts in T follicular helper cell responses to malaria

(2017) Diana S. Hansen et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Vaccination establishes clonal relatives of germinal center T cells in the blood of humans

(2017) Antje Heit et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction ofIL21in Peripheral T Follicular Helper Cells Is an Indicator of Influenza Vaccine Response in a Previously Vaccinated HIV-Infected Pediatric Cohort

(2017) Lesley R. de Armas et al.   JOURNAL OF IMMUNOLOGY

T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection

(2017) Suresh Pallikkuth et al.   Frontiers in Immunology

Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis

(2017) Sidhartha Chaudhury et al.   Scientific Reports

Circulating HIV-Specific Interleukin-21 + CD4 + T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions

(2016) Bruce T. Schultz et al.   IMMUNITY

Somatically Hypermutated Plasmodium-Specific IgM+ Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge

(2016) Akshay T. Krishnamurty et al.   IMMUNITY

Human Circulating T Follicular Helper Cell Subsets in Health and Disease

(2016) Hideki Ueno   JOURNAL OF CLINICAL IMMUNOLOGY

Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study

(2016) Jason A. Regules et al.   JOURNAL OF INFECTIOUS DISEASES

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

(2016) Colin Havenar-Daughton et al.   Cell Reports

Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans

(2016) Fabiana Spensieri et al.   PLoS One

Circulating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccine

(2016) Fouzia Farooq et al.   Scientific Reports

ICOS+PD-1+CXCR3+ T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

(2016) Salah-Eddine Bentebibel et al.   Scientific Reports

HIV infection Worsens Age-Associated Defects in Antibody Responses to Influenza Vaccine

(2015) Varghese K. George et al.   JOURNAL OF INFECTIOUS DISEASES

Ad35.CS.01 - RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults

(2015) Christian F. Ockenhouse et al.   PLoS One

Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

(2015) Silvia Portugal et al.   eLife

Circulating CXCR5+PD-1+Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

(2014) Ramin Sedaghat Herati et al.   JOURNAL OF IMMUNOLOGY

Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection

(2014) Kristin L. Boswell et al.   PLoS Pathogens

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Interleukin-21 and T follicular helper cells in HIV infection: research focus and future perspectives

(2013) Suresh Pallikkuth et al.   IMMUNOLOGIC RESEARCH

Inadequate T follicular cell help impairs B cell immunity during HIV infection

(2013) Rafael A Cubas et al.   NATURE MEDICINE

Changes in B Cell Populations and Merozoite Surface Protein-1-Specific Memory B Cell Responses after Prolonged Absence of Detectable P. falciparum Infection

(2013) Cyrus Ayieko et al.   PLoS One

The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection

(2013) Michael T. White et al.   PLoS One

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine

(2012) S. Pallikkuth et al.   BLOOD

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

Innate immune defects correlate with failure of antibody responses to H1N1/09 vaccine in HIV-infected patients

(2011) Suresh Pallikkuth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Upregulation of IL-21 Receptor on B Cells and IL-21 Secretion Distinguishes Novel 2009 H1N1 Vaccine Responders from Nonresponders among HIV-Infected Persons on Combination Antiretroviral Therapy

(2011) S. Pallikkuth et al.   JOURNAL OF IMMUNOLOGY

Protective Immunity Induced with the RTS,S/AS Vaccine Is Associated with IL-2 and TNF-α Producing Effector and Central Memory CD4+ T Cells

(2011) Joanne M. Lumsden et al.   PLoS One

Signals that influence T follicular helper cell differentiation and function

(2010) Michelle A. Linterman et al.   Seminars in Immunopathology

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

(2009) Nicholas Simpson et al.   ARTHRITIS AND RHEUMATISM

Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area

(2009) G. E. Weiss et al.   JOURNAL OF IMMUNOLOGY

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Development of the RTS,S/AS malaria candidate vaccine

(2009) Johan Vekemans et al.   VACCINE

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

Normalization of B Cell Counts and Subpopulations after Antiretroviral Therapy in Chronic HIV Disease

(2008) Susan Moir et al.   JOURNAL OF INFECTIOUS DISEASES

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

(2008) Jens Wrammert et al.   NATURE

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY