Immune system development varies according to age, location, and anemia in African children

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

(2019) Amy H. Lee et al.   Nature Communications

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

(2019) Ayelet Alpert et al.   NATURE MEDICINE

RTS,S malaria vaccine pilots in three African countries

(2019) Paul Adepoju   LANCET

The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

(2019) Danika L. Hill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses

(2019) Yuhang Jiang et al.   Nature Communications

Multi-omics profiling of mouse gastrulation at single-cell resolution

(2019) Ricard Argelaguet et al.   NATURE

Causes of impaired oral vaccine efficacy in developing countries

(2018) Edward PK Parker et al.   Future Microbiology

Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis

(2018) Carlson Tsui et al.   IMMUNITY

Lymphoid tissue fibrosis is associated with impaired vaccine responses

(2018) Cissy Kityo et al.   JOURNAL OF CLINICAL INVESTIGATION

Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets

(2018) Ricard Argelaguet et al.   Molecular Systems Biology

Non-specific effects of vaccines: Current evidence and potential implications

(2018) Charlotte L.C.J. de Bree et al.   SEMINARS IN IMMUNOLOGY

National and regional under-5 mortality rate by economic status for low-income and middle-income countries: a systematic assessment

(2018) Fengqing Chao et al.   Lancet Global Health

Stereotypic Immune System Development in Newborn Children

(2018) Axel Olin et al.   CELL

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

(2017) Tobias R. Kollmann et al.   IMMUNITY

Effects of nongenetic factors on immune cell dynamics in early childhood: The Generation R Study

(2017) Diana van den Heuvel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

(2017) Dmitri Kazmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccine responses in newborns

(2017) Anja Saso et al.   Seminars in Immunopathology

RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial

(2017) Gemma Moncunill et al.   Frontiers in Immunology

flowAI: automatic and interactive anomaly discerning tools for flow cytometry data

(2016) Gianni Monaco et al.   BIOINFORMATICS

The Generation R Study: design and cohort update 2017

(2016) Marjolein N. Kooijman et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Transient reduction in IgA + and IgG + memory B cell numbers in young EBV-seropositive children: the Generation R Study

(2016) Diana van den Heuvel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The cellular composition of the human immune system is shaped by age and cohabitation

(2016) Edward J Carr et al.   NATURE IMMUNOLOGY

Diffusion pseudotime robustly reconstructs lineage branching

(2016) Laleh Haghverdi et al.   NATURE METHODS

Shaping Variation in the Human Immune System

(2016) Adrian Liston et al.   TRENDS IN IMMUNOLOGY

The Immune System of HIV-Exposed Uninfected Infants

(2016) Bahaa Abu-Raya et al.   Frontiers in Immunology

destiny: diffusion maps for large-scale single-cell data in R

(2015) Philipp Angerer et al.   BIOINFORMATICS

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis

(2015) Mario Roederer et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Cytomegalovirus- and Epstein-Barr Virus–Induced T-Cell Expansions in Young Children Do Not Impair Naive T-cell Populations or Vaccination Responses: The Generation R Study

(2015) Diana van den Heuvel et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

(2015) Michael T White et al.   LANCET INFECTIOUS DISEASES

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

(2015) Haifa H Jabara et al.   NATURE GENETICS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

(2014) Enoch Muyanja et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Variants Regulating Immune Cell Levels in Health and Disease

(2013) Valeria Orrù et al.   CELL

Neonatal Follicular Th Cell Responses Are Impaired and Modulated by IL-4

(2013) I. Debock et al.   JOURNAL OF IMMUNOLOGY

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

(2013) Shuzhao Li et al.   NATURE IMMUNOLOGY

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Environmental and T Cell-Intrinsic Factors Limit the Expansion of Neonatal Follicular T Helper Cells but May Be Circumvented by Specific Adjuvants

(2012) B. Mastelic et al.   JOURNAL OF IMMUNOLOGY

Immunogenicity of the pentavalent rotavirus vaccine in African infants

(2012) George E. Armah et al.   VACCINE

Multiobjective evolutionary algorithms to identify highly autocorrelated areas: the case of spatial distribution in financially compromised farms

(2011) Carlos R. García-Alonso et al.   ANNALS OF OPERATIONS RESEARCH

Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2

(2011) M. Watanabe-Matsui et al.   BLOOD

Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood

(2011) Sytze de Roock et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development of standardized laboratory methods and quality processes for a phase III study of the RTS, S/AS01 candidate malaria vaccine

(2011) Christine Swysen et al.   MALARIA JOURNAL

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

"Default" Generation of Neonatal Regulatory T Cells

(2010) G. Wang et al.   JOURNAL OF IMMUNOLOGY

Effect of Human Rotavirus Vaccine on Severe Diarrhea in African Infants

(2010) Shabir A. Madhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells

(2008) E. Belnoue et al.   BLOOD