Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring

(2018) Elias Jabbour et al.   AMERICAN JOURNAL OF HEMATOLOGY

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

(2018) Jin-Young Lee et al.   Jove-Journal of Visualized Experiments

Hydroxycoumarin OT-55 kills CML cells alone or in synergy with imatinib or Synribo: Involvement of ER stress and DAMP release

(2018) Aloran Mazumder et al.   CANCER LETTERS

Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1’(R), 6’(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax

(2018) Cristina Florean et al.   Marine Drugs

Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery and Characterization of R/S-N-3-Cyanophenyl-N′-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines

(2017) Michael Schnekenburger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Global gene expression profiles of hematopoietic stem and progenitor cells from patients with chronic myeloid leukemia: the effect of in vitro culture with or without imatinib

(2017) Sócrates Avilés-Vázquez et al.   Cancer Medicine

4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer

(2016) Carole Seidel et al.   BIOCHEMICAL PHARMACOLOGY

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

(2016) Sheela A. Abraham et al.   NATURE

Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors

(2016) G Venton et al.   Blood Cancer Journal

Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition

(2016) M. T. Scott et al.   Cancer Discovery

Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

(2016) Cristina Florean et al.   Oncotarget

Epigenetic alterations as a universal feature of cancer hallmarks and a promising target for personalized treatments

(2015) Michael Schnekenburger et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Chronic myeloid leukaemia

(2015) Jane F Apperley   LANCET

Diagnosis and Treatment of Chronic Myeloid Leukemia in 2015

(2015) Philip A. Thompson et al.   MAYO CLINIC PROCEEDINGS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Leukemia stem cells: the root of chronic myeloid leukemia

(2015) Hong Zhou et al.   Protein & Cell

CML and tyrosine kinase inhibition: the hope becomes reality

(2015) Jane F Apperley   Lancet Haematology

HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities

(2015) Emily Koeneke et al.   Cells

STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia

(2015) Wolfgang Warsch et al.   Oncotarget

ArrayExpress update—simplifying data submissions

(2014) Nikolay Kolesnikov et al.   NUCLEIC ACIDS RESEARCH

5-aza-2′-deoxycytidine-mediated c-myc Down-regulation Triggers Telomere-dependent Senescence by Regulating Human Telomerase Reverse Transcriptase in Chronic Myeloid Leukemia

(2014) Cindy Grandjenette et al.   NEOPLASIA

Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases

(2013) Carole Seidel et al.   CANCER LETTERS

Protein Kinase and HDAC Inhibitors from the Endophytic Fungus Epicoccum nigrum

(2013) Mustapha El Amrani et al.   JOURNAL OF NATURAL PRODUCTS

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Chromatin-modifying agents in anti-cancer therapy

(2012) Carole Seidel et al.   BIOCHIMIE

Class I histone deacetylases localize to the endoplasmic reticulum and modulate the unfolded protein response

(2012) Soumen Kahali et al.   FASEB JOURNAL

Histone deacetylase modulators provided by Mother Nature

(2012) Carole Seidel et al.   Genes and Nutrition

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

(2012) N. Gammoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines

(2011) Tommy Karius et al.   BIOCHEMICAL PHARMACOLOGY

HDAC Inhibitors Potentiate the Activity of the BCR/ABL Kinase Inhibitor KW-2449 in Imatinib-Sensitive or -Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo

(2011) T. Nguyen et al.   CLINICAL CANCER RESEARCH

Novel Combination Treatments Targeting Chronic Myeloid Leukemia Stem Cells

(2011) Tareq Al Baghdadi et al.   Clinical Lymphoma Myeloma & Leukemia

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells

(2011) Luca A. Petruccelli et al.   PLoS One

Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells

(2011) Michele Cea et al.   PLoS One

Epigenomics of leukemia: from mechanisms to therapeutic applications

(2011) Cristina Florean et al.   Epigenomics

Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

(2010) Michael Schnekenburger et al.   BIOCHEMICAL PHARMACOLOGY

A framework for oligonucleotide microarray preprocessing

(2010) Benilton S. Carvalho et al.   BIOINFORMATICS

Treatment with Panobinostat Induces Glucose-Regulated Protein 78 Acetylation and Endoplasmic Reticulum Stress in Breast Cancer Cells

(2010) Rekha Rao et al.   MOLECULAR CANCER THERAPEUTICS

Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair

(2010) J.- H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

(2010) Julia M. Wagner et al.   Clinical Epigenetics

Histone Deacetylase Inhibitors in Cancer Therapy

(2009) Andrew A. Lane et al.   JOURNAL OF CLINICAL ONCOLOGY

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

(2008) Alan P. Kozikowski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Downregulation of Mcl-1 potentiates HDACi-mediated apoptosis in leukemic cells

(2008) S Inoue et al.   LEUKEMIA