Histone deacetylase modulators provided by Mother Nature

Urea cycle regulation by mitochondrial sirtuin, SIRT5

(2016) Takashi Nakagawa et al.   Aging-US

Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel

(2011) Chun-Fang Zou et al.   BMC CANCER

Epigenomics of leukemia: from mechanisms to therapeutic applications

(2011) Cristina Florean et al.   Epigenomics

Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells

(2010) Yun Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics

(2010) Alexander Link et al.   BIOCHEMICAL PHARMACOLOGY

Sustained exposure to the DNA demethylating agent, 2′-deoxy-5-azacytidine, leads to apoptotic cell death in chronic myeloid leukemia by promoting differentiation, senescence, and autophagy

(2010) Michael Schnekenburger et al.   BIOCHEMICAL PHARMACOLOGY

Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death

(2010) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells

(2010) Samir Attoub et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The DAC system and associations with acute leukemias and myelodysplastic syndromes

(2010) Gesine Bug et al.   INVESTIGATIONAL NEW DRUGS

The Role of HDAC6 in Cancer

(2010) Grace I. Aldana-Masangkay et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

(2010) Julia M. Wagner et al.   Clinical Epigenetics

3,3'-Diindolylmethane Enhances the Efficacy of Butyrate in Colon Cancer Prevention through Down-Regulation of Survivin

(2009) N. Bhatnagar et al.   Cancer Prevention Research

The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer

(2009) T. Liu et al.   CANCER RESEARCH

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells

(2009) Su Dao Xiong et al.   INTERNATIONAL JOURNAL OF CANCER

Activation of SIRT1 by Resveratrol Represses Transcription of the Gene for the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) by Deacetylating Hepatic Nuclear Factor 4α

(2009) Jianqi Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways

(2009) Michiko Aoyama et al.   NUTRITION

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A

(2008) Simon J. Crabb et al.   BIOCHEMICAL PHARMACOLOGY

Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter

(2008) H. Nian et al.   CARCINOGENESIS

Isoform-selective histone deacetylase inhibitors

(2008) Anton V. Bieliauskas et al.   CHEMICAL SOCIETY REVIEWS

Effects of FR235222, a novel HDAC inhibitor, in proliferation and apoptosis of human leukaemia cell lines: Role of Annexin A1

(2008) Antonello Petrella et al.   EUROPEAN JOURNAL OF CANCER

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation

(2008) Motonobu Watanabe et al.   INTERNATIONAL JOURNAL OF CANCER

Isoflavones Promote Mitochondrial Biogenesis

(2008) K. A. Rasbach et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor

(2008) Yongcheng Ying et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function

(2008) Shashwati Basak et al.   MOLECULAR CANCER THERAPEUTICS

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

(2008) Rui-Hong Wang et al.   MOLECULAR CELL

HDAC Inhibitors Act with 5-aza-2′-Deoxycytidine to Inhibit Cell Proliferation by Suppressing Removal of Incorporated Abases in Lung Cancer Cells

(2008) Guolin Chai et al.   PLoS One

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA