Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer

Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro

(2019) Brooke A. Pereira et al.   BIOMATERIALS

Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment

(2019) Elizabeth V Nguyen et al.   MOLECULAR & CELLULAR PROTEOMICS

Stromal Gene Expression is Predictive for Metastatic Primary Prostate Cancer

(2018) Fan Mo et al.   EUROPEAN UROLOGY

Enduring epigenetic landmarks define the cancer microenvironment

(2018) Ruth Pidsley et al.   GENOME RESEARCH

Genome-wide analysis of AR binding and comparison with transcript expression in primary human fetal prostate fibroblasts and cancer associated fibroblasts

(2018) Claire Nash et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

(2018) Rajeev Mishra et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner

(2018) Manabu Kato et al.   ONCOGENE

Complex formation between platelet-derived growth factor receptor β and transforming growth factor β receptor regulates the differentiation of mesenchymal stem cells into cancer-associated fibroblasts

(2018) Kaori Aoto et al.   Oncotarget

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Genomic hallmarks of localized, non-indolent prostate cancer

(2017) Michael Fraser et al.   NATURE

DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells

(2017) C Pistore et al.   ONCOGENE

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

(2017) Emarndeena H Cheteh et al.   Cell Death & Disease

Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

(2017) Svitlana Tyekucheva et al.   Nature Communications

Heterogeneous patterns of DNA methylation-based field effects in histologically normal prostate tissue from cancer patients

(2017) Mia Møller et al.   Scientific Reports

Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations

(2016) D. Bianchi-Frias et al.   MOLECULAR CANCER RESEARCH

10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer

(2016) Freddie C. Hamdy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients

(2016) Ahva Shahabi et al.   PROSTATE

Improved age determination of blood and teeth samples using a selected set of DNA methylation markers

(2015) Bram Bekaert et al.   Epigenetics

The Application of Synthetic Biology to Elucidation of Plant Mono-, Sesqui-, and Diterpenoid Metabolism

(2015) Naoki Kitaoka et al.   Molecular Plant

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

(2015) Colin S Cooper et al.   NATURE GENETICS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention

(2015) Malin Åkerfelt et al.   Oncotarget

Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study

(2015) H. Ross-Adams et al.   EBioMedicine

PROGgeneV2: enhancements on the existing database

(2015) Chirayu Pankaj Goswami et al.   BMC CANCER

Methylation Profiling Defines an Extensive Field Defect in Histologically Normal Prostate Tissues Associated with Prostate Cancer

(2015) Bing Yang et al.   NEOPLASIA

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

(2014) Martin J. Aryee et al.   BIOINFORMATICS

A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment

(2014) Stuart J Ellem et al.   JOURNAL OF PATHOLOGY

Ectodysplasin research—Where to next?

(2014) Sylvie Lefebvre et al.   SEMINARS IN IMMUNOLOGY

A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer

(2013) Ashlee K. Clark et al.   BIOMATERIALS

Prognostic Gleason grade grouping: data based on the modified Gleason scoring system

(2013) Phillip M. Pierorazio et al.   BJU INTERNATIONAL

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

A preclinical xenograft model of prostate cancer using human tumors

(2013) Mitchell G Lawrence et al.   Nature Protocols

A reciprocal role of prostate cancer on stromal DNA damage

(2013) J Banerjee et al.   ONCOGENE

Methylation of APC and GSTP1 in Non-Neoplastic Tissue Adjacent to Prostate Tumour and Mortality from Prostate Cancer

(2013) Lorenzo Richiardi et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

The ectodysplasin pathway: from diseases to adaptations

(2013) Alexa Sadier et al.   TRENDS IN GENETICS

Prostate Cancer Cell Telomere Length Variability and Stromal Cell Telomere Length as Prognostic Markers for Metastasis and Death

(2013) C. M. Heaphy et al.   Cancer Discovery

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Using the Epigenetic Field Defect to Detect Prostate Cancer in Biopsy Negative Patients

(2012) Matthew Truong et al.   JOURNAL OF UROLOGY

Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1

(2012) Z G Gulzar et al.   ONCOGENE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions

(2012) Kasper D Hansen et al.   GENOME BIOLOGY

Determining Prostate Cancer-Specific Death through Quantification of Stromogenic Carcinoma Area in Prostatectomy Specimens

(2011) Gustavo E. Ayala et al.   AMERICAN JOURNAL OF PATHOLOGY

Diagnosis of Prostate Cancer Using Differentially Expressed Genes in Stroma

(2011) Z. Jia et al.   CANCER RESEARCH

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate

(2011) B Orr et al.   ONCOGENE

Epigenetic Predictor of Age

(2011) Sven Bocklandt et al.   PLoS One

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Evidence for field cancerization of the prostate

(2009) Larisa Nonn et al.   PROSTATE