XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

(2018) Roberto Bellelli et al.   MOLECULAR CELL

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

(2018) Hind Ghezraoui et al.   NATURE

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells

(2018) Juan I. Garaycoechea et al.   NATURE

Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia

(2018) Carine Domenech et al.   Stem Cell Reports

ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes

(2017) Georgia Chatzinikolaou et al.   NATURE CELL BIOLOGY

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

(2015) Lucas B. Pontel et al.   MOLECULAR CELL

XPF-ERCC1 Acts in Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4

(2014) Daisy Klein Douwel et al.   MOLECULAR CELL

Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair

(2014) Michael R.G. Hodskinson et al.   MOLECULAR CELL

Understanding nucleotide excision repair and its roles in cancer and ageing

(2014) Jurgen A. Marteijn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency

(2014) Sander Barnhoorn et al.   PLoS Genetics

Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia

(2013) Kazuya Kashiyama et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fetal origins of hematopoietic failure in a murine model of Fanconi anemia

(2013) A. N. Kamimae-Lanning et al.   BLOOD

Cockayne syndrome: The expanding clinical and mutational spectrum

(2013) Vincent Laugel   MECHANISMS OF AGEING AND DEVELOPMENT

Shining a Light on Xeroderma Pigmentosum

(2012) John J. DiGiovanna et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

XPG and XPF Endonucleases Trigger Chromatin Looping and DNA Demethylation for Accurate Expression of Activated Genes

(2012) Nicolas Le May et al.   MOLECULAR CELL

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

(2012) Juan I. Garaycoechea et al.   NATURE

TFIIH: when transcription met DNA repair

(2012) Emmanuel Compe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis

(2012) Milica Enoiu et al.   NUCLEIC ACIDS RESEARCH

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria

(2012) I. Kamileri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Autonomous and Nonautonomous Mechanisms Drive Hematopoietic Stem/progenitor Cell Loss in the Absence of DNA Repair

(2012) Joon Seok Cho et al.   STEM CELLS

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

(2011) A. T. Wang et al.   GENES & DEVELOPMENT

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

(2011) Frédéric Langevin et al.   NATURE

Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology

(2011) Dick Jaarsma et al.   PLoS Genetics

Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair

(2010) P. T. Bradford et al.   JOURNAL OF MEDICAL GENETICS

NER Factors Are Recruited to Active Promoters and Facilitate Chromatin Modification for Transcription in the Absence of Exogenous Genotoxic Attack

(2010) Nicolas Le May et al.   MOLECULAR CELL

Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1

(2010) Kalindi Parmar et al.   STEM CELLS

Repair of Laser-localized DNA Interstrand Cross-links in G1Phase Mammalian Cells

(2009) Parameswary A. Muniandy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE

ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

(2008) A. Ahmad et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics