Deep reinforcement learning for the control of microbial co-cultures in bioreactors

The genetic basis for adaptation of model-designed syntrophic co-cultures

(2019) Colton J. Lloyd et al.   PLoS Computational Biology

Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance

(2019) Jeff Maltas et al.   PLOS BIOLOGY

Global stabilisation of continuous bioreactors: Tools for analysis and design of feeding laws

(2018) Hernán De Battista et al.   AUTOMATICA

Precise, automated control of conditions for high-throughput growth of yeast and bacteria with eVOLVER

(2018) Brandon G Wong et al.   NATURE BIOTECHNOLOGY

Control of a bioreactor using a new partially supervised reinforcement learning algorithm

(2018) B. Jaganatha Pandian et al.   JOURNAL OF PROCESS CONTROL

A user-friendly, low-cost turbidostat with versatile growth rate estimation based on an extended Kalman filter

(2017) Stefan A. Hoffmann et al.   PLoS One

Synchronized cycles of bacterial lysis for in vivo delivery

(2016) M. Omar Din et al.   NATURE

Metabolic Burden: Cornerstones in Synthetic Biology and Metabolic Engineering Applications

(2016) Gang Wu et al.   TRENDS IN BIOTECHNOLOGY

Population Density Modulates Drug Inhibition and Gives Rise to Potential Bistability of Treatment Outcomes for Bacterial Infections

(2016) Jason Karslake et al.   PLoS Computational Biology

Bioreactor control improves bioprocess performance

(2015) Rimvydas Simutis et al.   Biotechnology Journal

A synthetic growth switch based on controlled expression of RNA polymerase

(2015) J. Izard et al.   Molecular Systems Biology

Human-level control through deep reinforcement learning

(2015) Volodymyr Mnih et al.   NATURE

Distributing a metabolic pathway among a microbial consortium enhances production of natural products

(2015) Kang Zhou et al.   NATURE BIOTECHNOLOGY

The value of monitoring to control evolving populations

(2015) Andrej Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EngineeringEscherichia colicoculture systems for the production of biochemical products

(2015) Haoran Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioreactor control improves bioprocess performance

(2015) Rimvydas Simutis et al.   Biotechnology Journal

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

A Low Cost, Customizable Turbidostat for Use in Synthetic Circuit Characterization

(2014) Chris N. Takahashi et al.   ACS Synthetic Biology

Fitness and stability of obligate cross-feeding interactions that emerge upon gene loss in bacteria

(2013) Samay Pande et al.   ISME Journal

High-throughput gene expression analysis at the level of single proteins using a microfluidic turbidostat and automated cell tracking

(2012) G. Ullman et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Programmable Escherichia coli Consortium via Tunable Symbiosis

(2012) Alissa Kerner et al.   PLoS One

On-line optimization of fedbatch bioreactors by adaptive extremum seeking control

(2011) Pascal Cougnon et al.   JOURNAL OF PROCESS CONTROL

Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture

(2011) Kevin S. Lee et al.   LAB ON A CHIP

Stable coexistence of two Caldicellulosiruptor species in a de novo constructed hydrogen-producing co-culture

(2011) Ahmad A Zeidan et al.   Microbial Cell Factories

Simultaneous cell growth and ethanol production from cellulose by an engineered yeast consortium displaying a functional mini-cellulosome

(2011) Garima Goyal et al.   Microbial Cell Factories

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection

(2011) Erdal Toprak et al.   NATURE GENETICS

Advances and perspectives in in vitro human gut fermentation modeling

(2011) Amanda N. Payne et al.   TRENDS IN BIOTECHNOLOGY

Escherichia coli Binary Culture Engineered for Direct Fermentation of Hemicellulose to a Biofuel

(2010) H.-D. Shin et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Design of nonlinear PID controller and nonlinear model predictive controller for a continuous stirred tank reactor

(2009) J. Prakash et al.   ISA TRANSACTIONS

A synthetic Escherichia coli predator–prey ecosystem

(2008) Frederick K Balagaddé et al.   Molecular Systems Biology

How biotech can transform biofuels

(2008) Lee R Lynd et al.   NATURE BIOTECHNOLOGY

Engineering microbial consortia: a new frontier in synthetic biology

(2008) Katie Brenner et al.   TRENDS IN BIOTECHNOLOGY

A co-fermentation strategy to consume sugar mixtures effectively

(2008) Mark A Eiteman et al.   Journal of Biological Engineering