Activation of the SOX‐5, SOX‐6, and SOX‐9 Trio of Transcription Factors Using a Gene‐Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification

An In Vitro and In Vivo Comparison of Cartilage Growth in Chondrocyte-Laden Matrix Metalloproteinase-Sensitive Poly(Ethylene Glycol) Hydrogels with Localized Transforming Growth Factor β3

(2019) Margaret C. Schneider et al.   Acta Biomaterialia

Scaffold‐Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair

(2019) Domhnall C Kelly et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Surgical and tissue engineering strategies for articular cartilage and meniscus repair

(2019) Heenam Kwon et al.   Nature Reviews Rheumatology

Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: From development to application in tissue engineering

(2019) Rosanne M. Raftery et al.   BIOMATERIALS

In vitro efficacy of a gene-activated nerve guidance conduit incorporating non-viral PEI-pDNA nanoparticles carrying genes encoding for NGF, GDNF and c-Jun

(2018) William A. Lackington et al.   Acta Biomaterialia

Biomaterials for articular cartilage tissue engineering: Learning from biology

(2018) A.R. Armiento et al.   Acta Biomaterialia

Pro-angiogenic impact of SDF-1α gene-activated collagen-based scaffolds in stem cell driven angiogenesis

(2018) Ashang Luwang Laiva et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Delivery of the improved BMP-2-Advanced plasmid DNA within a gene-activated scaffold accelerates mesenchymal stem cell osteogenesis and critical size defect repair

(2018) Rosanne M. Raftery et al.   JOURNAL OF CONTROLLED RELEASE

Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration

(2018) Yoojun Nam et al.   Stem Cells International

In Vivo Evaluation of Biocompatibility and Chondrogenic Potential of a Cell-Free Collagen-Based Scaffold

(2017) Giovanna Calabrese et al.   Frontiers in Physiology

Multifunctional biomaterials from the sea: Assessing the effects of chitosan incorporation into collagen scaffolds on mechanical and biological functionality

(2016) Rosanne M. Raftery et al.   Acta Biomaterialia

Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits

(2016) Tanya J. Levingstone et al.   Acta Biomaterialia

Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives

(2016) Rosanne M. Raftery et al.   ADVANCED MATERIALS

Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints

(2016) Tanya J. Levingstone et al.   BIOMATERIALS

Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete

(2016) J. David Stack et al.   Journal of Tissue Engineering and Regenerative Medicine

Gene Transfer Strategies to Promote Chondrogenesis and Cartilage Regeneration

(2016) Gun-Il Im   TISSUE ENGINEERING PART B-REVIEWS

Development of a gene-activated scaffold platform for tissue engineering applications using chitosan-pDNA nanoparticles on collagen-based scaffolds

(2015) Rosanne M. Raftery et al.   JOURNAL OF CONTROLLED RELEASE

Scaffold Mean Pore Size Influences Mesenchymal Stem Cell Chondrogenic Differentiation and Matrix Deposition

(2015) Amos Matsiko et al.   TISSUE ENGINEERING PART A

Incorporation of TGF-Beta 3 within Collagen-Hyaluronic Acid Scaffolds Improves their Chondrogenic Potential

(2015) Amos Matsiko et al.   Advanced Healthcare Materials

A biomimetic multi-layered collagen-based scaffold for osteochondral repair

(2014) Tanya J. Levingstone et al.   Acta Biomaterialia

Recapitulating endochondral ossification: a promising route toin vivobone regeneration

(2014) Emmet M. Thompson et al.   Journal of Tissue Engineering and Regenerative Medicine

Control of chondrogenesis by the transcription factor Sox9

(2014) Haruhiko Akiyama   Modern Rheumatology

Combinatorial Gene Therapy Accelerates Bone Regeneration: Non-Viral Dual Delivery of VEGF and BMP2 in a Collagen-Nanohydroxyapatite Scaffold

(2014) Caroline M. Curtin et al.   Advanced Healthcare Materials

Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size

(2013) Qiu Li Loh et al.   TISSUE ENGINEERING PART B-REVIEWS

Advanced Strategies for Articular Cartilage Defect Repair

(2013) Amos Matsiko et al.   Materials

Mesenchymal Stem Cells in Tissue Repair

(2013) Amy M. DiMarino et al.   Frontiers in Immunology

Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation

(2012) Caroline M. Curtin et al.   ADVANCED MATERIALS

The postnatal role of Sox9 in cartilage

(2012) Stephen P Henry et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transcriptional Regulatory Cascades in Runx2-Dependent Bone Development

(2012) Tong Ming Liu et al.   TISSUE ENGINEERING PART B-REVIEWS

SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells

(2012) Jagadeesh K Venkatesan et al.   Stem Cell Research & Therapy

Chondrogenesis of human mesenchymal stem cells mediated by the combination of SOX trio SOX5, 6, and 9 genes complexed with PEI-modified PLGA nanoparticles

(2011) Ji Sun Park et al.   BIOMATERIALS

Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes

(2011) Gun-Il Im et al.   BIOMATERIALS

The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds

(2011) Erica G. Tierney et al.   JOURNAL OF CONTROLLED RELEASE

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering

(2011) Amos Matsiko et al.   Journal of the Mechanical Behavior of Biomedical Materials

Fibroblast Growth Factor-2 Primes Human Mesenchymal Stem Cells for Enhanced Chondrogenesis

(2011) Andrew M. Handorf et al.   PLoS One

Metabolic Activities and Chondrogenic Differentiation of Human Mesenchymal Stem Cells Following Recombinant Adeno-Associated Virus–Mediated Gene Transfer and Overexpression of Fibroblast Growth Factor 2

(2011) Magali Cucchiarini et al.   TISSUE ENGINEERING PART A

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

(2010) T. Hattori et al.   DEVELOPMENT

Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering

(2010) C. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of chitosan scaffold microstructure on mesenchymal stem cell chondrogenesis

(2009) Guillaume R. Ragetly et al.   Acta Biomaterialia

The effect of mean pore size on cell attachment, proliferation and migration in collagen–glycosaminoglycan scaffolds for bone tissue engineering

(2009) Ciara M. Murphy et al.   BIOMATERIALS

FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling

(2009) Hee-Jin Ahn et al.   FEBS LETTERS

Immunohistochemical study of collagen types I and II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantation

(2009) S. Roberts et al.   KNEE

Developmental Engineering: A New Paradigm for the Design and Manufacturing of Cell-Based Products. Part I: From Three-Dimensional Cell Growth to Biomimetics of In Vivo Development

(2009) Petros Lenas et al.   TISSUE ENGINEERING PART B-REVIEWS

Novel Freeze-Drying Methods to Produce a Range of Collagen–Glycosaminoglycan Scaffolds with Tailored Mean Pore Sizes

(2009) Matthew G. Haugh et al.   TISSUE ENGINEERING PART C-METHODS

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells

(2008) Michael B. Mueller et al.   ARTHRITIS AND RHEUMATISM

Marrow stimulation techniques

(2008) M.R. Steinwachs et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer

(2008) Y. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

The Potential of IGF-1 and TGFβ1 for Promoting “Adult” Articular Cartilage Repair: An In Vitro Study

(2008) Lindsay C. Davies et al.   TISSUE ENGINEERING PART A

Enhanced In Vitro Chondrogenesis of Primary Mesenchymal Stem Cells by Combined Gene Transfer

(2008) Andre F. Steinert et al.   TISSUE ENGINEERING PART A

How the Smads regulate transcription

(2007) Sarah Ross et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY