Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives
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Title
Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives
Authors
Keywords
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Journal
ADVANCED MATERIALS
Volume 28, Issue 27, Pages 5447-5469
Publisher
Wiley
Online
2016-02-04
DOI
10.1002/adma.201505088
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- (2015) Gouya Ram-Liebig et al. ADVANCED DRUG DELIVERY REVIEWS
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- (2015) Kelsey R. Beavers et al. ADVANCED DRUG DELIVERY REVIEWS
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- (2015) Bo Peng et al. ADVANCED DRUG DELIVERY REVIEWS
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- (2015) Kathleen A. Fitzgerald et al. BIOMATERIALS
- A Pilot Study Evaluating Combinatorial and Simultaneous Delivery of Polyethylenimine-Plasmid DNA Complexes Encoding for VEGF and PDGF for Bone Regeneration in Calvarial Bone Defects
- (2015) Sheetal D'Mello et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Biomaterials mediated microRNA delivery for bone tissue engineering
- (2015) M. Sriram et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Life in 3D is never flat: 3D models to optimise drug delivery
- (2015) Kathleen A. Fitzgerald et al. JOURNAL OF CONTROLLED RELEASE
- A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells
- (2015) Irene Mencía Castaño et al. JOURNAL OF CONTROLLED RELEASE
- Development of collagen–hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering
- (2015) Elaine Quinlan et al. JOURNAL OF CONTROLLED RELEASE
- Long-term controlled delivery of rhBMP-2 from collagen–hydroxyapatite scaffolds for superior bone tissue regeneration
- (2015) Elaine Quinlan et al. JOURNAL OF CONTROLLED RELEASE
- Development of a gene-activated scaffold platform for tissue engineering applications using chitosan-pDNA nanoparticles on collagen-based scaffolds
- (2015) Rosanne M. Raftery et al. JOURNAL OF CONTROLLED RELEASE
- Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a thoroughbred filly
- (2015) Florent David et al. Journal of Tissue Engineering and Regenerative Medicine
- Star-Shaped Polypeptides: Synthesis and Opportunities for Delivery of Therapeutics
- (2015) Mark Byrne et al. MACROMOLECULAR RAPID COMMUNICATIONS
- 23andMe sets sights on UK/Canada, signs up Genentech
- (2015) Asher Mullard NATURE BIOTECHNOLOGY
- IL-17–targeting biologics aim to become standard of care in psoriasis
- (2015) Mark Ratner NATURE BIOTECHNOLOGY
- Incorporation of TGF-Beta 3 within Collagen-Hyaluronic Acid Scaffolds Improves their Chondrogenic Potential
- (2015) Amos Matsiko et al. Advanced Healthcare Materials
- Switchable Release of Entrapped Nanoparticles from Alginate Hydrogels
- (2015) Cathal J. Kearney et al. Advanced Healthcare Materials
- Coupling Freshly Isolated CD44+Infrapatellar Fat Pad-Derived Stromal Cells with a TGF-β3 Eluting Cartilage ECM-Derived Scaffold as a Single-Stage Strategy for Promoting Chondrogenesis
- (2015) Henrique V. Almeida et al. Advanced Healthcare Materials
- Regulatory approval for autologous human cells and tissue products in the United States, the European Union, and Japan
- (2015) Kazuo Yano et al. Regenerative Therapy
- Osteochondral tissue regeneration through polymeric delivery of DNA encoding for the SOX trio and RUNX2
- (2014) Clark J. Needham et al. Acta Biomaterialia
- Post-transcriptional regulation in osteoblasts using localized delivery of miR-29a inhibitor from nanofibers to enhance extracellular matrix deposition
- (2014) Eric N. James et al. Acta Biomaterialia
- A biomimetic multi-layered collagen-based scaffold for osteochondral repair
- (2014) Tanya J. Levingstone et al. Acta Biomaterialia
- Bone Morphogenetic Proteins: Structure, biological function and therapeutic applications
- (2014) Ana Claudia Carreira et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Novel Microhydroxyapatite Particles in a Collagen Scaffold: A Bioactive Bone Void Filler?
- (2014) Frank G. Lyons et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- The role of transcription factors in prostate cancer and potential for future RNA interference therapy
- (2014) Kathleen A Fitzgerald et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Thermally triggered release of a pro-osteogenic peptide from a functionalized collagen-based scaffold using thermosensitive liposomes
- (2014) Adolfo López-Noriega et al. JOURNAL OF CONTROLLED RELEASE
- Target-specific delivery of siRNA by stabilized calcium phosphate nanoparticles using dopa–hyaluronic acid conjugate
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- Non-viral vectors for gene-based therapy
- (2014) Hao Yin et al. NATURE REVIEWS GENETICS
- Engineered Tissues as Customized Organ Germs
- (2014) Ivan Martin TISSUE ENGINEERING PART A
- Combinatorial Gene Therapy Accelerates Bone Regeneration: Non-Viral Dual Delivery of VEGF and BMP2 in a Collagen-Nanohydroxyapatite Scaffold
- (2014) Caroline M. Curtin et al. Advanced Healthcare Materials
- Synthetic Chemically Modified mRNA (modRNA): Toward a New Technology Platform for Cardiovascular Biology and Medicine
- (2014) K. R. Chien et al. Cold Spring Harbor Perspectives in Medicine
- Dendrimers: synthesis, applications, and properties
- (2014) Elham Abbasi et al. Nanoscale Research Letters
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- (2013) Satheesh Elangovan et al. BIOMATERIALS
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- (2013) Leandro G. Nandi et al. CARBOHYDRATE POLYMERS
- History of gene therapy
- (2013) Thomas Wirth et al. GENE
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- (2013) Kyuri Lee et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
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- (2013) Simon Fischer et al. JOURNAL OF BIOTECHNOLOGY
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- (2013) Zuzana Kadlecova et al. JOURNAL OF CONTROLLED RELEASE
- Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system
- (2013) J. McCarthy et al. JOURNAL OF CONTROLLED RELEASE
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- (2013) Anders Jacobsen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Treatment of HCV Infection by Targeting MicroRNA
- (2013) Harry L.A. Janssen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery
- (2013) C. A. Alabi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Marker-free plasmids for biotechnological applications – implications and perspectives
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- (2013) Erica G. Tierney et al. Organogenesis
- Molecular weight and architectural dependence of well-defined star-shaped poly(lysine) as a gene delivery vector
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- Silk constructs for delivery of musculoskeletal therapeutics
- (2012) Lorenz Meinel et al. ADVANCED DRUG DELIVERY REVIEWS
- Gene therapy approaches to regenerating bone
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- Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential
- (2012) Masato Sato et al. BMC MUSCULOSKELETAL DISORDERS
- Abstract 15: Phosphorylation defective mutant Bcl-xL knockin mice exhibit behavioral abnormalities linked with neurodevelopmental disorders
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- (2012) Stephanie Pritchard et al. CIRCULATION RESEARCH
- Low molecular weight oligochitosans for non-viral retinal gene therapy
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- Development of a microRNA delivery system based on bacteriophage MS2 virus-like particles
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- (2012) Conn L. Hastings et al. JOURNAL OF CONTROLLED RELEASE
- Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems
- (2012) Polina Ilina et al. JOURNAL OF CONTROLLED RELEASE
- High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix
- (2012) Erica G. Tierney et al. JOURNAL OF CONTROLLED RELEASE
- Evaluation of bone regeneration using the rat critical size calvarial defect
- (2012) Patrick P Spicer et al. Nature Protocols
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- (2012) Uelinton M. Pinto et al. NATURE REVIEWS MICROBIOLOGY
- Star polypeptides by NCA polymerisation from dendritic initiators: synthesis and enzyme controlled payload release
- (2012) Mark Byrne et al. Polymer Chemistry
- Engineering Complex Tissues
- (2012) A. Atala et al. Science Translational Medicine
- Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review
- (2011) Susmita Bose et al. Acta Biomaterialia
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- (2011) Peter F. M. Choong ANZ JOURNAL OF SURGERY
- Directing stem cell fate by controlled RNA interference
- (2011) Winifred Wing Yiu Yau et al. BIOMATERIALS
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- The MSC: An Injury Drugstore
- (2011) Arnold I. Caplan et al. Cell Stem Cell
- The Art of MicroRNA Research
- (2011) Eva van Rooij CIRCULATION RESEARCH
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- (2011) Gráinne M. Cunniffe et al. JOM
- The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds
- (2011) Erica G. Tierney et al. JOURNAL OF CONTROLLED RELEASE
- Addition of hyaluronic acid improves cellular infiltration and promotes early-stage chondrogenesis in a collagen-based scaffold for cartilage tissue engineering
- (2011) Amos Matsiko et al. Journal of the Mechanical Behavior of Biomedical Materials
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- (2011) Peter D. Mariner et al. Journal of Tissue Engineering and Regenerative Medicine
- Tissue-engineered autologous urethras for patients who need reconstruction: an observational study
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- (2011) Kirsten Severing MACROMOLECULAR BIOSCIENCE
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- (2011) Fergal J. O'Brien Materials Today
- Research Highlights
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- (2011) Ioannis V. Yannas et al. PLASTIC AND RECONSTRUCTIVE SURGERY
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- (2011) T. Eskildsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Table of Contents
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- Engineering RNA for Targeted siRNA Delivery and Medical Application
- (2010) Peixuan Guo et al. ADVANCED DRUG DELIVERY REVIEWS
- Genetically modified cells in regenerative medicine and tissue engineering☆
- (2010) Dima Sheyn et al. ADVANCED DRUG DELIVERY REVIEWS
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- (2010) Wilhelm K. Aicher et al. ADVANCED DRUG DELIVERY REVIEWS
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- Cyclodextrin-based gene delivery systems
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- (2010) T. Hattori et al. DEVELOPMENT
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- (2010) Rong Hu et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Gene therapy for bone healing
- (2010) Christopher H. Evans EXPERT REVIEWS IN MOLECULAR MEDICINE
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- (2010) Helen Atkinson et al. GENETICA
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- (2010) Gráinne M. Cunniffe et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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- (2010) Kenji Osawa et al. JOURNAL OF GENE MEDICINE
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- 20 years of gene therapy for SCID
- (2010) Alain Fischer et al. NATURE IMMUNOLOGY
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- (2010) P Jayakumar et al. PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
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- (2010) Jason W. Drexler et al. TISSUE ENGINEERING PART C-METHODS
- The Clinical Use of Human Culture–Expanded Autologous Bone Marrow Mesenchymal Stem Cells Transplanted on Platelet-Rich Fibrin Glue in the Treatment of Articular Cartilage Defects
- (2010) Amgad M. Haleem et al. Cartilage
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- (2009) Mariko Kawai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfection
- (2009) Sebastian Neumann et al. BIOMATERIALS
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- (2009) Ciara M. Murphy et al. BIOMATERIALS
- The ability of a collagen/calcium phosphate scaffold to act as its own vector for gene delivery and to promote bone formation via transfection with VEGF165
- (2009) Michael Keeney et al. BIOMATERIALS
- Physical methods of nucleic acid transfer: general concepts and applications
- (2009) Julien Villemejane et al. BRITISH JOURNAL OF PHARMACOLOGY
- Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
- (2009) Patrick Midoux et al. BRITISH JOURNAL OF PHARMACOLOGY
- Sleuthing the Source of Regeneration by MSCs
- (2009) Mark Pittenger Cell Stem Cell
- Cartilage repair: past and future - lessons for regenerative medicine
- (2009) Gerjo J. V. M. van Osch et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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- (2009) Yufeng Zhang et al. JOURNAL OF CONTROLLED RELEASE
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- (2009) J.T. Koh et al. JOURNAL OF DENTAL RESEARCH
- Nonviral siRNA Delivery to the Lung: Investigation of PEG−PEI Polyplexes and Their In Vivo Performance
- (2009) Olivia M. Merkel et al. MOLECULAR PHARMACEUTICS
- Complexity in biomaterials for tissue engineering
- (2009) Elsie S. Place et al. NATURE MATERIALS
- Functional Profiling Reveals Critical Role for miRNA in Differentiation of Human Mesenchymal Stem Cells
- (2009) Angela Schoolmeesters et al. PLoS One
- Progress in Tissue Engineering
- (2009) Ali Khademhosseini et al. SCIENTIFIC AMERICAN
- Improved Cartilage Regeneration Utilizing Mesenchymal Stem Cells in TGF-β1 Gene–Activated Scaffolds
- (2009) Huajia Diao et al. TISSUE ENGINEERING PART A
- Novel Freeze-Drying Methods to Produce a Range of Collagen–Glycosaminoglycan Scaffolds with Tailored Mean Pore Sizes
- (2009) Matthew G. Haugh et al. TISSUE ENGINEERING PART C-METHODS
- Liposomal gene delivery mediated by tissue-engineered scaffolds
- (2009) Mangesh Kulkarni et al. TRENDS IN BIOTECHNOLOGY
- Long-term delivery enhances in vivo osteogenic efficacy of bone morphogenetic protein-2 compared to short-term delivery
- (2008) Oju Jeon et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Bone regeneration after topical BMP-2-gene delivery in circumferential peri-implant bone defects
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- ESCGT 2008: Progress in Clinical Gene Therapy
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- (2008) Stephan Barrientos et al. WOUND REPAIR AND REGENERATION
- Genetic manipulation of human mesenchymal progenitors to promote chondrogenesis using “bead-in-bead” polysaccharide capsules
- (2007) Jodie C. Babister et al. BIOMATERIALS
- Non-viral gene transfection technologies for genetic engineering of stem cells
- (2007) Jun-ichiro Jo et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation
- (2007) Karen English et al. IMMUNOLOGY LETTERS
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