4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

(2016) Vassilios Bavetsias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Progress in Histone Demethylase Inhibitors

(2016) Tom E. McAllister et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

(2016) Ludovica Morera et al.   Clinical Epigenetics

SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2A

(2015) Weihua Xu et al.   BIOLOGICAL CHEMISTRY

Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A

(2015) Nicole Rüger et al.   ChemMedChem

Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation

(2015) Ke Liu et al.   PHARMACOLOGY & THERAPEUTICS

Targeting histone lysine methylation in cancer

(2015) John McGrath et al.   PHARMACOLOGY & THERAPEUTICS

Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells

(2015) Yukihiro Itoh et al.   ACS Medicinal Chemistry Letters

A Coding Single-Nucleotide Polymorphism in Lysine Demethylase KDM4A Associates with Increased Sensitivity to mTOR Inhibitors

(2015) C. Van Rechem et al.   Cancer Discovery

Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents

(2014) Jianjun Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor

(2014) Chia-Han Chu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase

(2013) Xuan Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G1/S transition

(2013) Masaharu Kogure et al.   CANCER LETTERS

Synthesis and Biological Evaluation of Biphenyl Amides That Modulate the US28 Receptor

(2013) Ana Kralj et al.   ChemMedChem

Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

(2013) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pan-Histone Demethylase Inhibitors Simultaneously Targeting Jumonji C and Lysine-Specific Demethylases Display High Anticancer Activities

(2013) Dante Rotili et al.   JOURNAL OF MEDICINAL CHEMISTRY

Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

(2012) Esther C. Y. Woon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An epigenetic role for PRL-3 as a regulator of H3K9 methylation in colorectal cancer

(2012) Yongxia Liu et al.   GUT

HDAC6 as a target for antileukemic drugs in acute myeloid leukemia

(2012) Björn Hackanson et al.   LEUKEMIA RESEARCH

The role of histone demethylases in cancer therapy

(2012) Inga Hoffmann et al.   Molecular Oncology

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Synthesis and biological evaluation of 3-aryltyramines as fragments binding to BACE-1 and BACE-2

(2012) Stefanie K. Fehler et al.   TETRAHEDRON LETTERS

Inhibitors of histone demethylases

(2011) Brian Lohse et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases

(2011) Xuelai Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer

(2011) Eric C. Kauffman et al.   MOLECULAR CARCINOGENESIS

Radical arylation of tyrosine and its application in the synthesis of a highly selective neurotensin receptor 2 ligand

(2011) Gerald Pratsch et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor   and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth

(2010) J. Yang et al.   CANCER RESEARCH

Radical Arylation of Phenols, Phenyl Ethers, and Furans

(2010) Alexander Wetzel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors

(2010) Shohei Hamada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

(2010) Oliver N. F. King et al.   PLoS One

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(ii)

(2009) Rok Sekirnik et al.   CHEMICAL COMMUNICATIONS

A Novel Mammalian Flavin-dependent Histone Demethylase

(2009) Aristotele Karytinos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of Amino- and Hydroxybiphenyls by Radical Chain Reaction of Arenediazonium Salts

(2008) Alexander Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases⊥

(2008) Nathan R. Rose et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

(2008) Agustín Valenzuela-Fernández et al.   TRENDS IN CELL BIOLOGY