Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds

A Fluxional Copper Acetylide Cluster in CuAAC Catalysis

(2015) Ata Makarem et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease

(2015) Lin Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

New, Non-quinone Fluorogeldanamycin Derivatives Strongly Inhibit Hsp90

(2015) Jekaterina Hermane et al.   CHEMBIOCHEM

Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid

(2015) Sabrina Nickel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies

(2015) Nasir K Bashiruddin et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Study of the Interface Interaction Mechanism Between 9,10-Bis(4-(1,2,2-triphenylvinyl) styryl)anthracene Film and Si Substrate

(2015) Shunyu Jin et al.   Science of Advanced Materials

Designing logical codon reassignment – Expanding the chemistry in biology

(2015) Anaëlle Dumas et al.   Chemical Science

In situ imaging and proteome profiling indicate andrographolide is a highly promiscuous compound

(2015) Lin Li et al.   Scientific Reports

Clickable Analogue of Cerulenin as Chemical Probe to Explore Protein Palmitoylation

(2014) Baohui Zheng et al.   ACS Chemical Biology

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

Reprogramming Nonribosomal Peptide Synthetases for “Clickable” Amino Acids

(2014) Hajo Kries et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Probes for the Functionalization of Polyketide Intermediates

(2014) Elena Riva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preparation of new alkyne-modified ansamitocins by mutasynthesis

(2014) Kirsten Harmrolfs et al.   Beilstein Journal of Organic Chemistry

A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

(2014) Xiamin Cheng et al.   CHEMICAL COMMUNICATIONS

Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation

(2014) Craig S. McKay et al.   CHEMISTRY & BIOLOGY

Building better bioorthogonal reactions

(2014) Hui-Wen Shih et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

(2013) Zhengqiu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advancements in the mechanistic understanding of the copper-catalyzed azide–alkyne cycloaddition

(2013) Regina Berg et al.   Beilstein Journal of Organic Chemistry

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Drug discovery considerations in the development of covalent inhibitors

(2013) Robert Mah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Copper-Assisted Click Reactions for Activity-Based Proteomics: Fine-Tuned Ligands and Refined Conditions Extend the Scope of Application

(2013) Georg C. Rudolf et al.   CHEMBIOCHEM

Identification of Widespread Adenosine Nucleotide Binding in Mycobacterium tuberculosis

(2013) Charles Ansong et al.   CHEMISTRY & BIOLOGY

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

(2013) Reggy Ekkebus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Simultaneous structure–activity studies and arming of natural products by C–H amination reveal cellular targets of eupalmerin acetate

(2013) Jing Li et al.   Nature Chemistry

Activity-Based Probes for Studying the Activity of Flavin-Dependent Oxidases and for the Protein Target Profiling of Monoamine Oxidase Inhibitors

(2012) Joanna M. Krysiak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

(2012) Tanja Wirth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells

(2012) Zhipeng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rugulactone and its Analogues Exert Antibacterial Effects through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis

(2012) Matthew B. Nodwell et al.   CHEMBIOCHEM

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy

(2012) Jürgen Eirich et al.   Molecular BioSystems

Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification

(2012) Oliver A. Battenberg et al.   Molecular BioSystems

Employing a polyketide synthase module and thioesterase in the semipreparative biocatalysis of diverse triketide pyrones

(2012) Amanda J. Hughes et al.   MedChemComm

Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes

(2011) Evelyn Zeiler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study

(2011) Christen Besanceney-Webler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: A comparative study

(2011) Wouter A. van der Linden et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Unraveling the Protein Targets of Vancomycin in Living S. aureus and E. faecalis Cells

(2011) Jürgen Eirich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

A Concise Asymmetric Total Synthesis of (+)-Brevisamide

(2011) Aaron T. Herrmann et al.   ORGANIC LETTERS

Identification of Direct Protein Targets of Small Molecules

(2010) Brett Lomenick et al.   ACS Chemical Biology

Bioorthogonal chemistry: recent progress and future directions

(2010) Reyna K. V. Lim et al.   CHEMICAL COMMUNICATIONS

Conversion of carbonyl compounds to alkynes: general overview and recent developments

(2010) Damien Habrant et al.   CHEMICAL SOCIETY REVIEWS

Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria

(2010) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteomics strategies for target identification and biomarker discovery in cancer

(2009) Uros Rajcevic   Frontiers in Bioscience-Landmark

A Suite of Activity-Based Probes for Human Cytochrome P450 Enzymes

(2009) Aaron T. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Myristoyl transferase-mediated protein labelling in vivo

(2008) William P. Heal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY