Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats

A comprehensive review on biological activities and toxicology of crocetin

(2019) Maryam Hashemi et al.   FOOD AND CHEMICAL TOXICOLOGY

Eugenol, a plant-derived phenolic nutraceutical, protects thiol (SH) group in myocardium from ROS-mediated oxidation under chemotherapeutic stress induced by arsenic trioxide – a in vivo model study

(2018) P. Binu et al.   DRUG AND CHEMICAL TOXICOLOGY

Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study

(2018) Naofumi Umigai et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Crocetin inhibits PDGF-BB-induced proliferation and migration of retinal pigment epithelial cells

(2018) He Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice

(2018) Jin Zhang et al.   Immunity & Ageing

Ellagic acid protects against arsenic trioxide–induced cardiotoxicity in rat

(2017) AA Hemmati et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Anti-tumor effects of crocetin and related molecular targets

(2017) Maliheh Moradzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Crocetin attenuates spared nerve injury-induced neuropathic pain in mice

(2017) Xiaolei Wang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I

(2017) Sunbin Ling et al.   Cell Death & Disease

Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2

(2017) Guanghong Xie et al.   Oncotarget

Crocetin treatment inhibits proliferation of colon cancer cells through down-regulation of genes involved in the inflammation

(2017) Xinying Zhuang et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats

(2016) Daqian Yang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Arsenic trioxide induces ROS activity and DNA damage, leading to G0/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway

(2016) Jutapon Chayapong et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells

(2016) Sreetama Choudhury et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective effects of oxymatrine against arsenic trioxide-induced liver injury

(2016) Li Li et al.   Oncotarget

Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway

(2016) Yue Zhang et al.   Oncotarget

T3 and T4 decrease ROS levels and increase endothelial nitric oxide synthase expression in the myocardium of infarcted rats

(2015) Alexandre Luz de Castro et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hepatic and Nephric NRF2 Pathway Up-Regulation, an Early Antioxidant Response, in Acute Arsenic-Exposed Mice

(2015) Jinlong Li et al.   International Journal of Environmental Research and Public Health

Protective effect of Emblica-officinalis in arsenic induced biochemical alteration and inflammation in mice

(2015) Manish K. Singh et al.   SpringerPlus

Effects and mechanisms of resveratrol on the amelioration of oxidative stress and hepatic steatosis in KKAy mice

(2014) Wei Zhu et al.   Nutrition & Metabolism

Resveratrol, a Natural Antioxidant, Has a Protective Effect on Liver Injury Induced by Inorganic Arsenic Exposure

(2014) Zhigang Zhang et al.   Biomed Research International

Crocetin Attenuates Spatial Learning Dysfunction and Hippocampal Injury in a Model of Vascular Dementia

(2013) Faezeh Tashakori-Sabzevar et al.   CURRENT NEUROVASCULAR RESEARCH

Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion

(2013) Shuang Gao et al.   FOOD AND CHEMICAL TOXICOLOGY

Activation of the Nrf2 Pathway by Inorganic Arsenic in Human Hepatocytes and the Role of Transcriptional Repressor Bach1

(2013) Dan Liu et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress induced by the chemotherapeutic agent arsenic trioxide

(2013) Mathews V. Varghese et al.   3 Biotech

Arsenic-Mediated Activation of the Nrf2-Keap1 Antioxidant Pathway

(2012) Alexandria Lau et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Evaluation of Adverse Cardiac Effects Induced by Arsenic Trioxide, a Potent Anti-APL Drug

(2012) K. G. Raghu et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells

(2010) Kyong Nyon Nam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats

(2008) Ismail Celik et al.   FOOD AND CHEMICAL TOXICOLOGY

Apoptosis in arsenic trioxide-treated Calu-6 lung cells is correlated with the depletion of GSH levels rather than the changes of ROS levels

(2008) Yong Hwan Han et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dithiothreitol abrogates the effect of arsenic trioxide on normal rat liver mitochondria and human hepatocellular carcinoma cells

(2007) Manash K. Paul et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY