Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 18, Issue 8, Pages 934-940Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op500083y
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An improved process for the preparation of solifenacin succinate (1) involving resolution through diastereomeric crystallization is described. (1S)-IQL derivative (5) is esterified to form (1S)-ethoxycarbonyl IQL derivative (6) which is condensed with (RS)-3-quinuclidinol (7) to form a solifenacin diastereomeric mixture (8); this is subjected to resolution through diastereomeric crystallization to produce solifenacin succinate (1), which is used for the treatment of an overactive bladder.
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