Journal
LEUKEMIA RESEARCH
Volume 35, Issue 10, Pages 1395-1401Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2011.03.012
Keywords
DQAsomes; Dequalinium; Antitumoral; Leukemia; Apoptosis; Glutathione; JNK; p38
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Funding
- Instituto de Salud Carlos III
- Comunidad de Madrid
- University of Alcala (UAH)
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Dequalinium, an amphiphilic quinolinium derivative, selectively accumulates in mitochondria and displays anticancer activity in cells from different malignancies. Previous studies indicate a differential DQA-induced cytotoxicity in NB4 and K562 human leukemia cells as a consequence of an early disturbance in mitochondrial function. Results in this paper show that DQA induces a concentration-dependent oxidative stress by decreasing GSH level and increasing ROS in a cell type specific way. Inhibitors of the JNK and p38 stress regulated kinases potentiate DQA-induced NB4 cell death suggesting a protective function for these enzymes. K562 cells with relatively high GSH levels remained resistant to DQA action. (C) 2011 Elsevier Ltd. All rights reserved.
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