Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

(2019) Luke Whitesell et al.   Nature Communications

On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds

(2019) Arturo Casadevall et al.   mBio

Candida auris and multidrug resistance: Defining the new normal

(2019) Shawn R. Lockhart   FUNGAL GENETICS AND BIOLOGY

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

(2019) Praveen R. Juvvadi et al.   Nature Communications

Understanding Echinocandin Resistance in the Emerging Pathogen Candida auris

(2018) Milena Kordalewska et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009–17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance

(2018) Anuradha Chowdhary et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

An outbreak due to Candida auris with prolonged colonisation and candidaemia in a tertiary care European hospital

(2018) Alba Ruiz-Gaitán et al.   MYCOSES

Rocaglates as dual-targeting agents for experimental cerebral malaria

(2018) David Langlais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA

(2018) Shintaro Iwasaki et al.   MOLECULAR CELL

A Candida auris Outbreak and Its Control in an Intensive Care Setting

(2018) David W. Eyre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species

(2018) José F. Muñoz et al.   Nature Communications

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma

(2017) Salomon Manier et al.   Science Translational Medicine

Regulated Forms of Cell Death in Fungi

(2017) A. Pedro Gonçalves et al.   Frontiers in Microbiology

Silvestrol induces early autophagy and apoptosis in human melanoma cells

(2016) Wei-Lun Chen et al.   BMC CANCER

Calcium and reactive oxygen species in regulation of the mitochondrial permeability transition and of programmed cell death in yeast

(2016) Michela Carraro et al.   CELL CALCIUM

Simultaneous Emergence of Multidrug-ResistantCandida aurison 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses

(2016) Shawn R. Lockhart et al.   CLINICAL INFECTIOUS DISEASES

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

(2016) Shintaro Iwasaki et al.   NATURE

Inhibiting fungal multidrug resistance by disrupting an activator–Mediator interaction

(2016) Joy L. Nishikawa et al.   NATURE

F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

(2016) Jason D. Oliver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organelle acidification negatively regulates vacuole membrane fusion in vivo

(2016) Yann Desfougères et al.   Scientific Reports

Cytotoxic Rocaglate Derivatives from Leaves of Aglaia perviridis

(2016) Fa-Liang An et al.   Scientific Reports

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A

(2016) Jennifer Chu et al.   Cell Reports

Programmed Cell Death Initiation and Execution in Budding Yeast

(2015) Randy Strich   GENETICS

The yeast Saccharomyces cerevisiae: An overview of methods to study autophagy progression

(2015) Elizabeth Delorme-Axford et al.   METHODS

Programmed Cell Death Initiation and Execution in Budding Yeast

(2015) Randy Strich   GENETICS

Activation of a TRP-like channel and intracellular Ca2+ dynamics during phospholipase-C-mediated cell death

(2014) A. P. Goncalves et al.   JOURNAL OF CELL SCIENCE

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

(2014) A. Y. Lee et al.   SCIENCE

Evidence for a Functionally Relevant Rocaglamide Binding Site on the eIF4A–RNA Complex

(2013) Heather Sadlish et al.   ACS Chemical Biology

Homotypic Vacuole Fusion in Yeast Requires Organelle Acidification and Not the V-ATPase Membrane Domain

(2013) Emily M. Coonrod et al.   DEVELOPMENTAL CELL

Therapeutic Potential of the Translation Inhibitor Silvestrol in Hepatocellular Cancer

(2013) Takayuki Kogure et al.   PLoS One

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

(2013) S. Santagata et al.   SCIENCE

Multifunction of autophagy-related genes in filamentous fungi

(2012) Irshad Ali Khan et al.   MICROBIOLOGICAL RESEARCH

First Three Reported Cases of Nosocomial Fungemia Caused by Candida auris

(2011) Wee Gyo Lee et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

(2011) R. S. Shapiro et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Systematic exploration of synergistic drug pairs

(2011) M. Cokol et al.   Molecular Systems Biology

Discovery of new antimalarial chemotypes through chemical methodology and library development

(2011) L. E. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation

(2010) Stéphane P. Roche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phylogenetic conservation of the preapoptotic calreticulin exposure pathway from yeast to mammals

(2010) Frank Madeo et al.   CELL CYCLE

Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry

(2009) Rebecca M. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Regulation of autophagy in yeast Saccharomyces cerevisiae

(2009) Eduardo Cebollero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells

(2009) Regina Cencic et al.   LEUKEMIA RESEARCH

Candida aurissp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital

(2009) Kazuo Satoh et al.   MICROBIOLOGY AND IMMUNOLOGY

Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

(2009) Regina Cencic et al.   PLoS One

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

(2009) Sheena D. Singh et al.   PLoS Pathogens

Programmed cell death in pathogenic fungi

(2008) Mark Ramsdale   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

(2008) Marie-Eve Bordeleau et al.   JOURNAL OF CLINICAL INVESTIGATION

Voa1p Functions in V-ATPase Assembly in the Yeast Endoplasmic Reticulum

(2008) Margret Ryan et al.   MOLECULAR BIOLOGY OF THE CELL

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE