Dihydroartemisinin Prevents Progression and Metastasis of Head and Neck Squamous Cell Carcinoma by Inhibiting Polarization of Macrophages in Tumor Microenvironment

Dihydroartemisinin Prevents Distant Metastasis of Laryngeal Carcinoma by Inactivating STAT3 in Cancer Stem Cells

(2020) Weiyi Wang et al.   MEDICAL SCIENCE MONITOR

Dihydroartemisinin attenuates lipopolysaccharide‑induced acute lung injury in mice by suppressing NF‑κB signaling in an Nrf2‑dependent manner

(2019) Xiao‑Ting Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Tumor associated macrophages in gynecologic cancers

(2018) Venkatesh Krishnan et al.   GYNECOLOGIC ONCOLOGY

Abberent expression of NOR1 protein in tumor associated macrophages contributes to the development of DEN-induced hepatocellular carcinoma

(2018) Shengnan Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Prognostic significance of CD68, CD163 and Folate receptor‑β positive macrophages in hepatocellular carcinoma

(2018) Koji Minami et al.   Experimental and Therapeutic Medicine

IL-6 influences the polarization of macrophages and the formation and growth of colorectal tumor

(2018) Lechuang Chen et al.   Oncotarget

Hemozoin-induced activation of human monocytes toward M2-like phenotype is partially reversed by antimalarial drugs-chloroquine and artemisinin

(2018) Deepali Bobade et al.   MicrobiologyOpen

Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling

(2018) Fei Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumor associated macrophages provide the survival resistance of tumor cells to hypoxic microenvironmental condition through IL-6 receptor-mediated signals

(2017) Soo Kyung Jeong et al.   IMMUNOBIOLOGY

Safety, tolerability, and efficacy of repeated doses of dihydroartemisinin-piperaquine for prevention and treatment of malaria: a systematic review and meta-analysis

(2017) Julie Gutman et al.   LANCET INFECTIOUS DISEASES

Clinical Outcome of Reconstruction Using Frozen Autograft for a Humeral Bone Tumor

(2016) HIROAKI KIMURA et al.   ANTICANCER RESEARCH

Celastrus orbiculatus extract inhibits the migration and invasion of human glioblastoma cells in vitro

(2016) Hao Gu et al.   BMC Complementary and Alternative Medicine

CD163 + M2-type tumor-associated macrophage support the suppression of tumor-infiltrating T cells in osteosarcoma

(2016) Qinglin Han et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

(2016) Yong Hu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Prognostic significance of macrophage polarization in early stage oral squamous cell carcinomas

(2016) Manuel Weber et al.   ORAL ONCOLOGY

Downregulation of sphingosine kinase-1 induces protective tumor immunity by promoting M1 macrophage response in melanoma

(2016) Marguerite Mrad et al.   Oncotarget

Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling

(2016) Lifeng Jia et al.   PLoS One

M2-polarized macrophages contribute to neovasculogenesis, leading to relapse of oral cancer following radiation

(2016) Makiko Okubo et al.   Scientific Reports

Macrophage polarisation changes within the time between diagnostic biopsy and tumour resection in oral squamous cell carcinomas—an immunohistochemical study

(2015) M Weber et al.   BRITISH JOURNAL OF CANCER

Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling

(2015) Yu-Peng Liu et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

High infiltration of tumor-associated macrophages is associated with a poor response to chemotherapy and poor prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer

(2015) Keijiro Sugimura et al.   JOURNAL OF SURGICAL ONCOLOGY

Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways

(2015) Banudevi Sivanantham et al.   ACS Combinatorial Science

Association of macrophages with angiogenesis in oral verrucous and squamous cell carcinomas

(2015) Dalia H. El-Rouby   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Inhibition of JAK1, 2/STAT3 Signaling Induces Apoptosis, Cell Cycle Arrest, and Reduces Tumor Cell Invasion in Colorectal Cancer Cells

(2015) Hua Xiong et al.   NEOPLASIA

Insights into the role of components of the tumor microenvironment in oral carcinoma call for new therapeutic approaches

(2014) Tuula Salo et al.   EXPERIMENTAL CELL RESEARCH

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Induction of Murine Macrophage M2 Polarization by Cigarette Smoke Extract via the JAK2/STAT3 Pathway

(2014) Fengjiao Yuan et al.   PLoS One

CD163+ Tumor-Associated Macrophages Correlated with Poor Prognosis and Cancer Stem Cells in Oral Squamous Cell Carcinoma

(2014) Ke-Fei He et al.   Biomed Research International

Dihydroartemisinin induces autophagy by suppressing NF-κB activation

(2013) Wei Hu et al.   CANCER LETTERS

ROS sets the stage for macrophage differentiation

(2013) Anthony Covarrubias et al.   CELL RESEARCH

Inhibitory effect of dihydroartemisinin against phorbol ester-induced cyclooxygenase-2 expression in macrophages

(2013) Hyung Gyun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Effects of celecoxib treatment over the AKT pathway in head and neck squamous cell carcinoma

(2013) Aline Corrêa Abrahão et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Design, Synthesis and Evaluation of the Antibacterial Enhancement Activities of Amino Dihydroartemisinin Derivatives

(2013) Chong Wu et al.   MOLECULES

Tracking metastasis and tricking cancer

(2013) Vivien Marx   NATURE

Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma

(2013) C. Lu-Emerson et al.   NEURO-ONCOLOGY

Activation of STAT3 in Human Gastric Cancer Cells via Interleukin (IL)-6-Type Cytokine Signaling Correlates with Clinical Implications

(2013) Zhengguang Wang et al.   PLoS One

Enhanced IL-12p40 production in LPS-stimulated macrophages by inhibiting JNK activation by artemisinin

(2012) Young-Chang Cho et al.   ARCHIVES OF PHARMACAL RESEARCH

Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation

(2012) Daisuke Shiraishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo

(2012) Chris Zhiyi Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

Dihydroartemisinin shift the immune response towards Th1, inhibit the tumor growth in vitro and in vivo

(2011) Shokoofe Noori et al.   CELLULAR IMMUNOLOGY

Stat3 Mediates Expression of Autotaxin in Breast Cancer

(2011) Janeen Azare et al.   PLoS One

Infiltration of M2 Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma Correlates with Tumor Malignancy

(2011) Kazumasa Mori et al.   Cancers

Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma

(2010) Horlad Hasita et al.   CANCER SCIENCE

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination

(2009) B. D. Robinson et al.   CLINICAL CANCER RESEARCH

Head and Neck Cancer: Changing Epidemiology, Diagnosis, and Treatment

(2009) Shanthi Marur et al.   MAYO CLINIC PROCEEDINGS