Hemozoin-induced activation of human monocytes toward M2-like phenotype is partially reversed by antimalarial drugs-chloroquine and artemisinin

Chloroquine (CQ) exerts anti-breast cancer through modulating microenvironment and inducing apoptosis

(2017) Yanjun Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway

(2017) Ruiling Liu et al.   PLoS One

The M2 macrophages induce autophagic vascular disorder and promote mouse sensitivity to urethane-related lung carcinogenesis

(2016) G.-G. Li et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model

(2016) María E. Cabalén et al.   Oncotarget

Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity

(2016) J. Brice Weinberg et al.   Scientific Reports

Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation

(2015) Yanwei Wu et al.   Cellular & Molecular Immunology

Malaria-derived hemozoin exerts early modulatory effects on the phenotype and maturation of human dendritic cells

(2015) Ioana Bujila et al.   CELLULAR MICROBIOLOGY

Orosomucoid 1 drives opportunistic infections through the polarization of monocytes to the M2b phenotype

(2015) Kiwamu Nakamura et al.   CYTOKINE

M2b Monocytes Provoke Bacterial Pneumonia and Gut Bacteria-Associated Sepsis in Alcoholics

(2015) Y. Tsuchimoto et al.   JOURNAL OF IMMUNOLOGY

Infection-related hemolysis and susceptibility to Gram-negative bacterial co-infection

(2015) Katharine Orf et al.   Frontiers in Microbiology

M2 Polarization of Human Macrophages Favors Survival of the Intracellular Pathogen Chlamydia pneumoniae

(2015) Tanja Buchacher et al.   PLoS One

Critical role of p38 MAPK in IL-4-induced alternative activation of peritoneal macrophages

(2014) Lidia Jiménez-Garcia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Malarial Pigment Hemozoin and the Innate Inflammatory Response

(2014) Martin Olivier et al.   Frontiers in Immunology

Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis

(2013) Minghua Yang et al.   BIOCHEMICAL PHARMACOLOGY

Inhibitory effect of dihydroartemisinin against phorbol ester-induced cyclooxygenase-2 expression in macrophages

(2013) Hyung Gyun Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Human immune responses to Plasmodium falciparum infection: molecular evidence for a suboptimal THαβ and TH17 bias over ideal and effective traditional TH1 immune response

(2013) Wan-Chung Hu   MALARIA JOURNAL

Association of high plasma TNF-alpha levels and TNF-alpha/IL-10 ratios with TNF2 allele in severeP. falciparummalaria patients in Sri Lanka

(2013) M. K. Perera et al.   Pathogens and Global Health

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Haemozoin Induces Early Cytokine-Mediated Lysozyme Release from Human Monocytes through p38 MAPK- and NF-kappaB- Dependent Mechanisms

(2012) Manuela Polimeni et al.   PLoS One

Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action

(2011) V. Barrera et al.   BLOOD

Artemisinins and immune system

(2011) Lubna Shakir et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Obstacles and opportunities for understanding macrophage polarization

(2011) P. J. Murray et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology

(2010) P. A. Buffet et al.   BLOOD

Role of the NF-κB transcription pathway in the haemozoin- and 15-HETE-mediated activation of matrix metalloproteinase-9 in human adherent monocytes

(2010) Mauro Prato et al.   CELLULAR MICROBIOLOGY

Complement driven innate immune response to malaria: fuelling severe malarial diseases

(2010) Karlee L. Silver et al.   CELLULAR MICROBIOLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Involvement of Inflammatory Chemokines in Survival of Human Monocytes Fed with Malarial Pigment

(2010) G. Giribaldi et al.   INFECTION AND IMMUNITY

Efficacy of artemisinin in experimental visceral leishmaniasis

(2010) Rupashree Sen et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes

(2010) Wang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

M2b Monocytes Predominated in Peripheral Blood of Severely Burned Patients

(2010) M. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization

(2010) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

Innate inflammatory response to the malarial pigment hemozoin

(2010) Marina T. Shio et al.   MICROBES AND INFECTION

SM905, an artemisinin derivative, inhibited NO and pro-inflammatory cytokine production by suppressing MAPK and NF-κB pathways in RAW 264.7 macrophages

(2009) Jun-xia Wang et al.   ACTA PHARMACOLOGICA SINICA

Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics

(2009) Kellen L. Olszewski et al.   Cell Host & Microbe

Filarial Lymphedema Is Characterized by Antigen-Specific Th1 and Th17 Proinflammatory Responses and a Lack of Regulatory T Cells

(2009) Subash Babu et al.   PLoS Neglected Tropical Diseases

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: Involvement of p38 MAPK and ERK

(2007) Masakazu Kono et al.   ANTIVIRAL RESEARCH