HIV-1 Proviral Transcription and Latency in the New Era

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

(2020) Julia Bergild McBrien et al.   NATURE

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

(2020) Christopher C. Nixon et al.   NATURE

Chromatin maturation of the HIV-1 provirus in primary resting CD4+ T cells

(2020) Birgitta Lindqvist et al.   PLoS Pathogens

Curing HIV: Seeking to Target and Clear Persistent Infection

(2020) David M. Margolis et al.   CELL

HIV/AIDS Research for the Future

(2020) Robert C. Gallo   Cell Host & Microbe

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies

(2020) Lillian B. Cohn et al.   Cell Host & Microbe

KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs

(2020) Curtis W. Bacon et al.   MOLECULAR CELL

NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release

(2020) Yuki Aoi et al.   MOLECULAR CELL

Physical principles of retroviral integration in the human genome

(2019) D. Michieletto et al.   Nature Communications

Entry of Polarized Effector Cells into Quiescence Forces HIV Latency

(2019) Curtis Dobrowolski et al.   mBio

Cat and Mouse: HIV Transcription in Latency, Immune Evasion and Cure/Remission Strategies

(2019) Aurélie Delannoy et al.   Viruses-Basel

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

(2019) Katherine M. Bruner et al.   NATURE

Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy

(2019) Kevin B. Einkauf et al.   JOURNAL OF CLINICAL INVESTIGATION

Ending the HIV Epidemic

(2019) Anthony S. Fauci et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transcriptional Circuit Fragility Influences HIV Proviral Fate

(2019) Emily L. Morton et al.   Cell Reports

An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion

(2019) Kizhakke Mattada Sathyan et al.   GENES & DEVELOPMENT

Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform

(2019) Eytan Herzig et al.   CELL

The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation

(2019) Melissa-Rose Abrahams et al.   Science Translational Medicine

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

(2019) Pilar Garcia-Broncano et al.   Science Translational Medicine

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

(2019) Bojana Lucic et al.   Nature Communications

Targeting HIV-1 proviral transcription

(2019) Alex Olson et al.   Current Opinion in Virology

CD4+ T Cell Subsets and Pathways to HIV Latency

(2018) Luis M. Agosto et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV

(2018) Youry Kim et al.   Cell Host & Microbe

Targeting the Latent Reservoir for HIV-1

(2018) Srona Sengupta et al.   IMMUNITY

The dTAG system for immediate and target-specific protein degradation

(2018) Behnam Nabet et al.   Nature Chemical Biology

Born to run: control of transcription elongation by RNA polymerase II

(2018) Fei Xavier Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane

(2018) Zheng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell RNA-Seq Reveals Transcriptional Heterogeneity in Latent and Reactivated HIV-Infected Cells

(2018) Monica Golumbeanu et al.   Cell Reports

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

(2018) Tyler B Faust et al.   eLife

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

(2018) Pilar Mendoza et al.   NATURE

High-throughput chromatin accessibility profiling at single-cell resolution

(2018) Anja Mezger et al.   Nature Communications

HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact

(2018) Luis M. Agosto et al.   Cell Reports

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

(2018) Melissa Kane et al.   eLife

The role of integration and clonal expansion in HIV infection: live long and prosper

(2018) Elizabeth M. Anderson et al.   Retrovirology

CRISPR-Cas9-based Genome Engineering to Generate Jurkat Reporter Models for HIV-1 Infection with Selected Proviral Integration Sites

(2018) Julia K. Bialek et al.   Jove-Journal of Visualized Experiments

HIV-1 Latency by Transition

(2017) Boris Julg et al.   IMMUNITY

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4 + T Cells Permissive for Latent HIV-1 Infection

(2017) Liang Shan et al.   IMMUNITY

Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells

(2017) Guinevere Q. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Proliferation of latently infected CD4+T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics

(2017) Nina N. Hosmane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes

(2017) Ryan J. Conrad et al.   MOLECULAR CELL

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

(2017) Georg E. Winter et al.   MOLECULAR CELL

Paused RNA polymerase II inhibits new transcriptional initiation

(2017) Wanqing Shao et al.   NATURE GENETICS

Unravelling HIV-1 Latency, One Cell at a Time

(2017) Yik Lim Kok et al.   TRENDS IN MICROBIOLOGY

Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

(2017) Kien Nguyen et al.   mBio

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

(2017) Cari F. Kessing et al.   Cell Reports

Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation

(2017) Alberto Bosque et al.   Cell Reports

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4 + T Cells from Effectively Treated Participants

(2017) Bonnie Hiener et al.   Cell Reports

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

(2017) John K. Bui et al.   PLoS Pathogens

CDK9-dependent RNA polymerase II pausing controls transcription initiation

(2017) Saskia Gressel et al.   eLife

Simultaneous measurement of chromatin accessibility, DNA methylation, and nucleosome phasing in single cells

(2017) Sebastian Pott   eLife

The Molecular Basis for Human Immunodeficiency Virus Latency

(2017) Uri Mbonye et al.   Annual Review of Virology

The 3D Genome as Moderator of Chromosomal Communication

(2016) Job Dekker et al.   CELL

What Integration Sites Tell Us about HIV Persistence

(2016) Stephen H. Hughes et al.   Cell Host & Microbe

Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+T CellsIn Vitro

(2016) Jennifer M. Zerbato et al.   JOURNAL OF VIROLOGY

A Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency

(2016) Zichong Li et al.   MOLECULAR AND CELLULAR BIOLOGY

KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II

(2016) Ryan P. McNamara et al.   MOLECULAR CELL

Defective proviruses rapidly accumulate during acute HIV-1 infection

(2016) Katherine M Bruner et al.   NATURE MEDICINE

Regulatory activities of transposable elements: from conflicts to benefits

(2016) Edward B. Chuong et al.   NATURE REVIEWS GENETICS

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Nuclear landscape of HIV-1 infection and integration

(2016) Marina Lusic et al.   NATURE REVIEWS MICROBIOLOGY

Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

(2016) Katharine J. Bar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy

(2016) Hiromi Imamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA

(2016) Julio C. C. Lorenzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonally expanded CD4+T cells can produce infectious HIV-1 in vivo

(2016) Francesco R. Simonetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

7SKiing on chromatin: Move globally, act locally

(2016) Iván D'Orso   RNA Biology

The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer

(2016) Courtney Hodges et al.   Cold Spring Harbor Perspectives in Medicine

Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal

(2016) Mateusz Stoszko et al.   EBioMedicine

A Hardwired HIV Latency Program

(2015) Brandon S. Razooky et al.   CELL

HIV-1 Integration Landscape during Latent and Active Infection

(2015) Lillian B. Cohn et al.   CELL

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

(2015) Lars Pache et al.   Cell Host & Microbe

Didehydro-Cortistatin A Inhibits HIV-1 Tat Mediated Neuroinflammation and Prevents Potentiation of Cocaine Reward in Tat Transgenic Mice

(2015) Sonia Mediouni et al.   CURRENT HIV RESEARCH

The interplay of histone modifications - writers that read

(2015) T. Zhang et al.   EMBO REPORTS

FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency

(2015) Huachao Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies

(2015) Amanda M. Crooks et al.   JOURNAL OF INFECTIOUS DISEASES

Impact of Nucleoporin-Mediated Chromatin Localization and Nuclear Architecture on HIV Integration Site Selection

(2015) Richard W. Wong et al.   JOURNAL OF VIROLOGY

Nuclear architecture dictates HIV-1 integration site selection

(2015) Bruna Marini et al.   NATURE

Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state

(2015) Assaf Rotem et al.   NATURE BIOTECHNOLOGY

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells

(2015) Leonard Chavez et al.   PLoS Pathogens

Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

(2015) C. Kadoch et al.   Science Advances

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat

(2014) N. M. Archin et al.   JOURNAL OF INFECTIOUS DISEASES

Negative Elongation Factor Is Required for the Maintenance of Proviral Latency but Does Not Induce Promoter-Proximal Pausing of RNA Polymerase II on the HIV Long Terminal Repeat

(2014) J. K. Jadlowsky et al.   MOLECULAR AND CELLULAR BIOLOGY

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Eradicating HIV-1 infection: seeking to clear a persistent pathogen

(2014) Nancie M. Archin et al.   NATURE REVIEWS MICROBIOLOGY

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones

(2014) Tomohiko Kanno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stochastic variability in HIV affects viral eradication: Fig. 1.

(2014) Igor M. Rouzine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

(2014) A. R. Cillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure

(2014) Uri Mbonye et al.   VIROLOGY

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Correction: Yeast Genetic Analysis Reveals the Involvement of Chromatin Reassembly Factors in Repressing HIV-1 Basal Transcription

(2014) Manuela Vanti et al.   PLoS Genetics

Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause Regions

(2014) John M. Pagano et al.   PLoS Genetics

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

An Integrated Overview of HIV-1 Latency

(2013) Debbie S. Ruelas et al.   CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release

(2013) Wen Liu et al.   CELL

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

(2013) Daniela Boehm et al.   CELL CYCLE

Single-cell Hi-C reveals cell-to-cell variability in chromosome structure

(2013) Takashi Nagano et al.   NATURE

AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation

(2013) H. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV latency and integration site placement in five cell-based models

(2013) Scott Sherrill-Mix et al.   Retrovirology

Reactivation of latent HIV by histone deacetylase inhibitors

(2013) Kotaro Shirakawa et al.   TRENDS IN MICROBIOLOGY

Epigenetic analysis of HIV-1 proviral genomes from infected individuals: Predominance of unmethylated CpG's

(2013) Stefanie Weber et al.   VIROLOGY

Lost in Transcription: Molecular Mechanisms that Control HIV Latency

(2013) Ran Taube et al.   Viruses-Basel

Transcription Factors Mediate the Enzymatic Disassembly of Promoter-Bound 7SK snRNP to Locally Recruit P-TEFb for Transcription Elongation

(2013) Ryan P. McNamara et al.   Cell Reports

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

An Analog of the Natural Steroidal Alkaloid Cortistatin A Potently Suppresses Tat-Dependent HIV Transcription

(2012) Guillaume Mousseau et al.   Cell Host & Microbe

Control of HIV Latency by Epigenetic and Non-Epigenetic Mechanisms

(2012) Jonathan Karn et al.   CURRENT HIV RESEARCH

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules

(2012) T. K. Kelly et al.   GENOME RESEARCH

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

(2012) Camellia Banerjee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An AP-1 Binding Site in the Enhancer/Core Element of the HIV-1 Promoter Controls the Ability of HIV-1 To Establish Latent Infection

(2012) A. Duverger et al.   JOURNAL OF VIROLOGY

Paucity of HIV DNA Methylation in Latently Infected, Resting CD4+ T Cells from Infected Individuals Receiving Antiretroviral Therapy

(2012) J. Blazkova et al.   JOURNAL OF VIROLOGY

Transition Step during Assembly of HIV Tat:P-TEFb Transcription Complexes and Transfer to TAR RNA

(2012) I. D'Orso et al.   MOLECULAR AND CELLULAR BIOLOGY

The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output

(2012) Z. Luo et al.   MOLECULAR AND CELLULAR BIOLOGY

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

A Flexible Model of HIV-1 Latency Permitting Evaluation of Many Primary CD4 T-Cell Reservoirs

(2012) Kara G. Lassen et al.   PLoS One

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold

(2012) S. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

(2012) B. N. Devaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway

(2011) Young Kyeung Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

Chromatin Reassembly Factors Are Involved in Transcriptional Interference Promoting HIV Latency

(2011) E. Gallastegui et al.   JOURNAL OF VIROLOGY

Global landscape of HIV–human protein complexes

(2011) Stefanie Jäger et al.   NATURE

Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency

(2011) Haleh Rafati et al.   PLOS BIOLOGY

Transcriptional Bursting from the HIV-1 Promoter Is a Significant Source of Stochastic Noise in HIV-1 Gene Expression

(2010) Abhyudai Singh et al.   BIOPHYSICAL JOURNAL

Pausing of RNA Polymerase II Disrupts DNA-Specified Nucleosome Organization to Enable Precise Gene Regulation

(2010) Daniel A. Gilchrist et al.   CELL

Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II

(2010) S. H. Kwon et al.   GENES & DEVELOPMENT

Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294

(2010) Kenichi Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction

(2010) M. Tyagi et al.   JOURNAL OF VIROLOGY

Mapping the architecture of the HIV-1 Tat circuit: A decision-making circuit that lacks bistability and exploits stochastic noise

(2010) Brandon S. Razooky et al.   METHODS

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

(2010) Chengqi Lin et al.   MOLECULAR CELL

HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

(2010) Bijan Sobhian et al.   MOLECULAR CELL

KAP1 controls endogenous retroviruses in embryonic stem cells

(2010) Helen M. Rowe et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation

(2010) Iván D'Orso et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex

(2010) A. Missra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription through the HIV-1 nucleosomes: Effects of the PBAF complex in Tat activated transcription

(2010) Rebecca Easley et al.   VIROLOGY

NF-κB/Rel: agonist and antagonist roles in HIV-1 latency

(2010) Jonathan KL Chan et al.   Current Opinion in HIV and AIDS

The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit

(2010) Jonathan Karn   Current Opinion in HIV and AIDS

Loss of the Brm-Type SWI/SNF Chromatin Remodeling Complex Is a Strong Barrier to the Tat-Independent Transcriptional Elongation of Human Immunodeficiency Virus Type 1 Transcripts

(2009) T. Mizutani et al.   JOURNAL OF VIROLOGY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Nucleosome positioning and gene regulation: advances through genomics

(2009) Cizhong Jiang et al.   NATURE REVIEWS GENETICS

A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP

(2009) Y. Xue et al.   NUCLEIC ACIDS RESEARCH

In vitro nuclear interactome of the HIV-1 Tat protein

(2009) Virginie W Gautier et al.   Retrovirology

CpG Methylation Controls Reactivation of HIV from Latency

(2009) Jana Blazkova et al.   PLoS Pathogens

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells

(2008) A. Bosque et al.   BLOOD

Orientation-Dependent Regulation of Integrated HIV-1 Expression by Host Gene Transcriptional Readthrough

(2008) Yefei Han et al.   Cell Host & Microbe

Transcriptional Interference Antagonizes Proviral Gene Expression to Promote HIV Latency

(2008) Tina Lenasi et al.   Cell Host & Microbe

Regulation of an inducible promoter by an HP1β–HP1γ switch

(2008) Bogdan Mateescu et al.   EMBO REPORTS

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

(2008) R. Pearson et al.   JOURNAL OF VIROLOGY

A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis

(2008) Nanhai He et al.   MOLECULAR CELL

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

(2008) B. J. Krueger et al.   NUCLEIC ACIDS RESEARCH

The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription

(2008) Chiara Vardabasso et al.   Retrovirology

Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR

(2008) Rachel Van Duyne et al.   Retrovirology