SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient

(2020) Sean Wei Xiang Ong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Presumed Asymptomatic Carrier Transmission of COVID-19

(2020) Yan Bai et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

(2020) Calvin J Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Augmented Intelligence (AI) in Detecting and Preventing the Spread of Novel Coronavirus

(2020) Justin B. Long et al.   JOURNAL OF MEDICAL SYSTEMS

Development and Clinical Application of A Rapid IgM‐IgG Combined Antibody Test for SARS‐CoV‐2 Infection Diagnosis

(2020) Zhengtu Li et al.   JOURNAL OF MEDICAL VIROLOGY

Genomic variance of the 2019‐nCoV coronavirus

(2020) Carmine Ceraolo et al.   JOURNAL OF MEDICAL VIROLOGY

Combination of RT‐qPCR Testing and Clinical Features For Diagnosis of COVID‐19 facilitates management of SARS‐CoV‐2 Outbreak

(2020) Yishan Wang et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

(2020) Lirong Zou et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

(2020) Emmie de Wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

Active Monitoring of Persons Exposed to Patients with Confirmed COVID-19 — United States, January–February 2020

(2020) Rachel M. Burke et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

On the origin and continuing evolution of SARS-CoV-2

(2020) Xiaolu Tang et al.   National Science Review

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines

(2020) Weilong Shang et al.   npj Vaccines

Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks

(2020) Hossam M. Ashour et al.   Pathogens

Is BCG vaccination affecting the spread and severity of COVID‐19?

(2020) Cevdet Ozdemir et al.   ALLERGY

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

(2020) Junwen Luan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia

(2020) Shengyu Zhang et al.   CLINICAL DRUG INVESTIGATION

Whole genome and phylogenetic analysis of two SARS-CoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe

(2020) Paola Stefanelli et al.   Eurosurveillance

SARS-CoV-2 Vaccines: Status Report

(2020) Fatima Amanat et al.   IMMUNITY

Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies

(2020) Ming Zhao   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

(2020) Chi Zhang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A Review of SARS-CoV-2 and the Ongoing Clinical Trials

(2020) Yung-Fang Tu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

(2020) Maria Pachetti et al.   Journal of Translational Medicine

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

WITHDRAWN: Is global BCG vaccination coverage relevant to the progression of SARS-CoV-2 pandemic?

(2020) Mayda Gursel et al.   MEDICAL HYPOTHESES

The race for coronavirus vaccines: a graphical guide

(2020) Ewen Callaway   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

The pandemic pipeline

(2020) John Hodgson   NATURE BIOTECHNOLOGY

Fast, portable tests come online to curb coronavirus pandemic

(2020) Cormac Sheridan   NATURE BIOTECHNOLOGY

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

The COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

(2020) Neeltje van Doremalen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phylogenetic network analysis of SARS-CoV-2 genomes

(2020) Peter Forster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

(2020) Kai Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)

(2020) Ruiyun Li et al.   SCIENCE

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

(2020) Jianjun Gao et al.   BioScience Trends

Tocilizumab: A new opportunity in the possible therapeutic arsenal against COVID-19

(2020) Yeimer Ortiz-Martínez   Travel Medicine and Infectious Disease

Airborne Transmission Route of COVID-19: Why 2 Meters/6 Feet of Inter-Personal Distance Could Not Be Enough

(2020) Leonardo Setti et al.   International Journal of Environmental Research and Public Health

Seasonality of Respiratory Viral Infections

(2020) Miyu Moriyama et al.   Annual Review of Virology

Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) — United States, February 12–March 16, 2020

(2020) et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Favorable changes of CT findings in a patient with COVID-19 pneumonia after treatment with tocilizumab

(2020) M. Cellina et al.   Diagnostic and Interventional Imaging

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study

(2020) Qingxian Cai et al.   Engineering

Airborne transmission of SARS-CoV-2: The world should face the reality

(2020) Lidia Morawska et al.   ENVIRONMENT INTERNATIONAL

No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection

(2020) J.M. Molina et al.   MEDECINE ET MALADIES INFECTIEUSES

Association between climate variables and global transmission oF SARS-CoV-2

(2020) Marcos Felipe Falcão Sobral et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Impact of temperature on the dynamics of the COVID-19 outbreak in China

(2020) Peng Shi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica)

(2019) Ping Liu et al.   Viruses-Basel

Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience

(2018) Jae-Hoon Ko et al.   ANTIVIRAL THERAPY

Nextstrain: real-time tracking of pathogen evolution

(2018) James Hadfield et al.   BIOINFORMATICS

Why are RNA virus mutation rates so damn high?

(2018) Siobain Duffy   PLOS BIOLOGY

RNA Virus Fidelity Mutants: A Useful Tool for Evolutionary Biology or a Complex Challenge?

(2018) Tiffany Kautz et al.   Viruses-Basel

1,2,3-Triazolyl ester of Ketorolac: A “Click Chemistry”-based highly potent PAK1-blocking cancer-killer

(2017) Binh Cao Quan Nguyen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase

(2017) Nidhi Kaushik et al.   JOURNAL OF VIROLOGY

Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase

(2017) Yousuke FURUTA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

The not-so-infinite malleability of RNA viruses: Viral and cellular determinants of RNA virus mutation rates

(2017) Everett Clinton Smith   PLoS Pathogens

Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice

(2017) Chunfeng Li et al.   EBioMedicine

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo- and Paramyxoviruses

(2017) Michael K. Lo et al.   Scientific Reports

Anti-inflammatory activity of chloroquine and amodiaquine through p21-mediated suppression of T cell proliferation and Th1 cell differentiation

(2016) Sera Oh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chloroquine could be used for the treatment of filoviral infections and other viral infections that emerge or emerged from viruses requiring an acidic pH for infectivity

(2016) Hephzibah Akpovwa   CELL BIOCHEMISTRY AND FUNCTION

RNA Recombination Enhances Adaptability and Is Required for Virus Spread and Virulence

(2016) Yinghong Xiao et al.   Cell Host & Microbe

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model

(2015) Stuart D. Dowall et al.   JOURNAL OF GENERAL VIROLOGY

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

(2015) Jasper Fuk-Woo Chan et al.   JOURNAL OF INFECTIOUS DISEASES

Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

(2015) Satish Patil et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

(2015) Guangwen Lu et al.   TRENDS IN MICROBIOLOGY

Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer’s Disease

(2015) Steven H. Liang et al.   ACS Medicinal Chemistry Letters

Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

(2014) Adriaan H. de Wilde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Coronaviruses Induce Entry-Independent, Continuous Macropinocytosis

(2014) M. C. Freeman et al.   mBio

Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

(2014) Christine Burkard et al.   PLoS Pathogens

Synergistic combinations of favipiravir and oseltamivir against wild-type pandemic and oseltamivir-resistant influenza A virus infections in mice

(2013) Donald F Smee et al.   Future Virology

Development of novel entry inhibitors targeting emerging viruses

(2012) Yanchen Zhou et al.   Expert Review of Anti-Infective Therapy

Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

(2012) Sandrine Belouzard et al.   Viruses-Basel

Role of the p21-activated kinases (PAKs) in influenza A virus replication

(2011) Philippe Noriel Q. Pascua et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Convalescent Plasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza A (H1N1) 2009 Virus Infection

(2011) I. F. Hung et al.   CLINICAL INFECTIOUS DISEASES

SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission

(2011) Meagan Bolles et al.   Current Opinion in Virology

Effects of Air Temperature and Relative Humidity on Coronavirus Survival on Surfaces

(2010) L. M. Casanova et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

An emerging role for p21-activated kinases (Paks) in viral infections

(2010) Celine Van den Broeke et al.   TRENDS IN CELL BIOLOGY