Development of novel entry inhibitors targeting emerging viruses

Ebola virus entry requires the host-programmed recognition of an intracellular receptor

(2012) Emily Happy Miller et al.   EMBO JOURNAL

A New Class of Synthetic Peptide Inhibitors Blocks Attachment and Entry of Human Pathogenic Viruses

(2012) Marcel Krepstakies et al.   JOURNAL OF INFECTIOUS DISEASES

Filoviruses Require Endosomal Cysteine Proteases for Entry but Exhibit Distinct Protease Preferences

(2012) J. Misasi et al.   JOURNAL OF VIROLOGY

Rapid Screening for Entry Inhibitors of Highly Pathogenic Viruses under Low-Level Biocontainment

(2012) Aparna Talekar et al.   PLoS One

Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression

(2012) Kerstin Gnirß et al.   VIROLOGY

The Curious Case of Arenavirus Entry, and Its Inhibition

(2012) Jack H. Nunberg et al.   Viruses-Basel

PD 404,182 Is a Virocidal Small Molecule That Disrupts Hepatitis C Virus and Human Immunodeficiency Virus

(2011) Ana Maria Chamoun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitors of SARS-CoV entry – Identification using an internally-controlled dual envelope pseudovirion assay

(2011) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Class II enveloped viruses

(2011) Marie-Christine Vaney et al.   CELLULAR MICROBIOLOGY

Small molecule HIV entry inhibitors: Part II. Attachment and fusion inhibitors: 2004 – 2010

(2011) Inder Pal Singh et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Promotion of vesicular stomatitis virus fusion by the endosome-specific phospholipid bis(monoacylglycero)phosphate (BMP)

(2011) Shoshannah L. Roth et al.   FEBS LETTERS

Capturing a Fusion Intermediate of Influenza Hemagglutinin with a Cholesterol-conjugated Peptide, a New Antiviral Strategy for Influenza Virus

(2011) Kelly K. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Ebola Virus Entry by a C-peptide Targeted to Endosomes

(2011) Emily Happy Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions

(2011) Megan J. Brooks et al.   JOURNAL OF MEDICAL VIROLOGY

Discovery, Synthesis, and Biological Evaluation of a Novel Group of Selective Inhibitors of Filoviral Entry

(2011) Maria V. Yermolina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Identification of a Small-Molecule Entry Inhibitor for Filoviruses

(2011) A. Basu et al.   JOURNAL OF VIROLOGY

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

Fusing structure and function: a structural view of the herpesvirus entry machinery

(2011) Sarah A. Connolly et al.   NATURE REVIEWS MICROBIOLOGY

Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol

(2011) Elodie Teissier et al.   PLoS One

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

(2011) H.-H. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus

(2011) A. S. Kondratowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway

(2011) Nirupama Mulherkar et al.   VIROLOGY

Different host cell proteases activate the SARS-coronavirus spike-protein for cell–cell and virus–cell fusion

(2011) Graham Simmons et al.   VIROLOGY

Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus

(2011) Mohammad F. Saeed et al.   PLoS Pathogens

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

Identification of a Dendrimeric Heparan Sulfate-Binding Peptide That Inhibits Infectivity of Genital Types of Human Papillomaviruses

(2010) M. Donalisio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Specific Interaction of Small Molecule Entry Inhibitors with the Envelope Glycoprotein Complex of the Junín Hemorrhagic Fever Arenavirus

(2010) Celestine J. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Viral Entry Inhibitors Targeted to the Membrane Site of Action

(2010) M. Porotto et al.   JOURNAL OF VIROLOGY

A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells

(2010) P. P. Shah et al.   MOLECULAR PHARMACOLOGY

Structural changes of envelope proteins during alphavirus fusion

(2010) Long Li et al.   NATURE

A broad-spectrum antiviral targeting entry of enveloped viruses

(2010) M. C. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Small Molecule Inhibitor of Hepatitis C Virus Entry

(2010) Carl J. Baldick et al.   PLoS Pathogens

Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes

(2010) Mohammad F. Saeed et al.   PLoS Pathogens

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

Dengue Virus Ensures Its Fusion in Late Endosomes Using Compartment-Specific Lipids

(2010) Elena Zaitseva et al.   PLoS Pathogens

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections

(2009) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

A Forward Genetic Strategy Reveals Destabilizing Mutations in the Ebolavirus Glycoprotein That Alter Its Protease Dependence during Cell Entry

(2009) A. C. Wong et al.   JOURNAL OF VIROLOGY

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Trapping Moving Targets with Small Molecules

(2009) G. M. Lee et al.   SCIENCE

Nipah virus entry can occur by macropinocytosis

(2009) Olivier Pernet et al.   VIROLOGY

A catalytically and genetically optimized β-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics

(2009) Mike C Wolf et al.   Virology Journal

Capturing a Flavivirus Pre-Fusion Intermediate

(2009) Bärbel Kaufmann et al.   PLoS Pathogens

Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N

(2008) D SMEE et al.   ANTIVIRAL RESEARCH

Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol

(2008) Irina A. Leneva et al.   ANTIVIRAL RESEARCH

Arbidol: A Broad-Spectrum Antiviral Compound that Blocks Viral Fusion

(2008) Y. Boriskin et al.   CURRENT MEDICINAL CHEMISTRY

Protease-Mediated Entry via the Endosome of Human Coronavirus 229E

(2008) M. Kawase et al.   JOURNAL OF VIROLOGY

Identification of a Broad-Spectrum Arenavirus Entry Inhibitor

(2008) R. A. Larson et al.   JOURNAL OF VIROLOGY

pH-Induced Activation of Arenavirus Membrane Fusion Is Antagonized by Small-Molecule Inhibitors

(2008) J. York et al.   JOURNAL OF VIROLOGY

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE

Surfen, a small molecule antagonist of heparan sulfate

(2008) M. Schuksz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of endocytosis and cathepsin-mediated activation in Nipah virus entry

(2008) Sandra Diederich et al.   VIROLOGY