Journal
ORGANIC LETTERS
Volume 16, Issue 21, Pages 5824-5826Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol502956j
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Funding
- National Natural Science Foundation of China [NSFC 21404096]
- Fundamental Research Funds for the Central Universities of China [WK2060190022, WK2060190026]
- USTC
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A highly efficient ruthenium-catalyzed stereospecific N-demethylative rearrangement of isoxazolidines to synthetically useful N-H-1,3-oxazinanes is described. 1,3-Oxazinanes are useful building blocks, which can be further converted to N-H-1,3-aminoalcohols in one step. This new method was used in a three-step gram-scale total synthesis of HPA-12 in an overall 24% yield.
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