DNA Origami‐Enabled Engineering of Ligand–Drug Conjugates for Targeted Drug Delivery

Shear Stress-Enhanced Internalization of Cell Membrane Proteins Indicated by a Hairpin-Type DNA Probe

(2018) Ziyi He et al.   ANALYTICAL CHEMISTRY

Visualization of the Cellular Uptake and Trafficking of DNA Origami Nanostructures in Cancer Cells

(2018) Pengfei Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Smart cancer therapy with DNA origami

(2018) Ennio Tasciotti   NATURE BIOTECHNOLOGY

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

A ribonucleoprotein octamer for targeted siRNA delivery

(2018) Wanyi Tai et al.   Nature Biomedical Engineering

DNA Nanostructure-Programmed Like-Charge Attraction at the Cell-Membrane Interface

(2018) Hongming Ding et al.   ACS Central Science

Rationally Designed DNA-Origami Nanomaterials for Drug Delivery In Vivo

(2018) Qiao Jiang et al.   ADVANCED MATERIALS

Concept and Development of Framework Nucleic Acids

(2018) Zhilei Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury

(2018) Dawei Jiang et al.   Nature Biomedical Engineering

mRNA-Initiated, Three-Dimensional DNA Amplifier Able to Function inside Living Cells

(2017) Lei He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials

(2017) Steven Bloom et al.   Nature Chemistry

Next generation antibody drugs: pursuit of the 'high-hanging fruit'

(2017) Paul J. Carter et al.   NATURE REVIEWS DRUG DISCOVERY

DNA nanotechnology

(2017) Nadrian C. Seeman et al.   Nature Reviews Materials

Cellular delivery of enzyme-loaded DNA origami

(2016) Ari Ora et al.   CHEMICAL COMMUNICATIONS

Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

(2015) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Complex wireframe DNA origami nanostructures with multi-arm junction vertices

(2015) Fei Zhang et al.   Nature Nanotechnology

Designing DNA nanodevices for compatibility with the immune system of higher organisms

(2015) Sunaina Surana et al.   Nature Nanotechnology

DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

(2015) Veikko Linko et al.   TRENDS IN BIOTECHNOLOGY

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Human C-Type Lectin-like Molecule-1 (CLL1) with a Bispecific Antibody for Immunotherapy of Acute Myeloid Leukemia

(2014) Hua Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bridging Disulfides for Stable and Defined Antibody Drug Conjugates

(2014) George Badescu et al.   BIOCONJUGATE CHEMISTRY

Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System

(2014) Erik S. Zimmerman et al.   BIOCONJUGATE CHEMISTRY

Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

(2014) Penelope M. Drake et al.   BIOCONJUGATE CHEMISTRY

Site-Specific Antibody–Polymer Conjugates for siRNA Delivery

(2013) Hua Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody–drug conjugates

(2013) Rachel S. Zolot et al.   NATURE REVIEWS DRUG DISCOVERY

Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics

(2013) G. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bispecific small molecule-antibody conjugate targeting prostate cancer

(2013) C. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties

(2012) Yong-Xing Zhao et al.   ACS Nano

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

DNA Origami as a Carrier for Circumvention of Drug Resistance

(2012) Qiao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

(2012) Peter D Senter et al.   NATURE BIOTECHNOLOGY

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

(2011) Jiang Li et al.   ACS Nano

Trastuzumab Emtansine: A Unique Antibody-Drug Conjugate in Development for Human Epidermal Growth Factor Receptor 2-Positive Cancer

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Stability of DNA Origami Nanoarrays in Cell Lysate

(2011) Qian Mei et al.   NANO LETTERS

Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

(2010) Anas Younes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Template-Directed Nucleation and Growth of Inorganic Nanoparticles on DNA Scaffolds

(2009) Linda A. Stearns et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phase I Biodistribution and Pharmacokinetic Study of Lewis Y-Targeting Immunoconjugate CMD-193 in Patients with Advanced Epithelial Cancers

(2009) R. A. Herbertson et al.   CLINICAL CANCER RESEARCH

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY