An ocular glymphatic clearance system removes β-amyloid from the rodent eye

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

(2019) Jerrah K. Holth et al.   SCIENCE

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

Time- and dose-related effects of amyloid beta1-40 on retina and optic nerve morphology in rats

(2018) Mohd Aizuddin Mohd Lazaldin et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Optic Disc Drusen in Children

(2018) Lasse Malmqvist et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Characterizing the glymphatic influx by utilizing intracisternal infusion of fluorescently conjugated cadaverine

(2018) Cui Zhang et al.   LIFE SCIENCES

Intracranial pressure and glaucoma: Is there a new therapeutic perspective on the horizon?

(2018) Peter Wostyn et al.   MEDICAL HYPOTHESES

Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes

(2018) Per Kristian Eide et al.   Scientific Reports

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

(2018) Humberto Mestre et al.   eLife

Dilated Prelaminar Paravascular Spaces as a Possible Mechanism for Optic Disc Edema in Astronauts

(2018) Peter Wostyn et al.   Aerospace Medicine and Human Performance

Age-related posterior ciliary muscle restriction – A link between trabecular meshwork and optic nerve head pathophysiology

(2017) Mary Ann Croft et al.   EXPERIMENTAL EYE RESEARCH

Unconventional aqueous humor outflow: A review

(2017) Mark Johnson et al.   EXPERIMENTAL EYE RESEARCH

Assessment of the dynamics of human glymphatic system by near-infrared spectroscopy

(2017) Teemu Myllylä et al.   Journal of Biophotonics

The pathway of subarachnoid CSF moving into the spinal parenchyma and the role of astrocytic aquaporin-4 in this process

(2017) Fang Wei et al.   LIFE SCIENCES

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

The Glymphatic Hypothesis of Glaucoma: A Unifying Concept Incorporating Vascular, Biomechanical, and Biochemical Aspects of the Disease

(2017) Peter Wostyn et al.   Biomed Research International

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

(2017) Martina Absinta et al.   eLife

Comparison of laser and circumlimbal suture induced elevation of intraocular pressure in albino CD-1 mice

(2017) Hsin-Hua Liu et al.   PLoS One

Retinal glymphatic system: an explanation for transient retinal layer volume changes?

(2016) Axel Petzold   BRAIN

The Outflow Pathway: A Tissue With Morphological and Functional Unity

(2016) Sergio Claudio Saccà et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Value of Mouse Models for Glaucoma Drug Discovery

(2016) W. Michael Dismuke et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Shrinkage-mediated imaging of entire organs and organisms using uDISCO

(2016) Chenchen Pan et al.   NATURE METHODS

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

(2016) Weiguo Peng et al.   NEUROBIOLOGY OF DISEASE

Intravital Imaging Reveals Dynamics of Lymphangiogenesis and Valvulogenesis

(2016) Gyeong Jin Kang et al.   Scientific Reports

Elevated intracranial pressure causes optic nerve and retinal ganglion cell degeneration in mice

(2015) Derek M. Nusbaum et al.   EXPERIMENTAL EYE RESEARCH

Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities

(2015) Kimberly A. Fernandes et al.   EXPERIMENTAL EYE RESEARCH

Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?

(2015) Vesa Kiviniemi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

(2015) Kaoru Yamamoto et al.   Cell Reports

Astrocyte Processes Label for Filamentous Actin and Reorient Early Within the Optic Nerve Head in a Rat Glaucoma Model

(2014) S. Tehrani et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina

(2013) Allen R. Rodriguez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Cannulation of the internal carotid artery in mice: A novel technique for intra-arterial delivery of therapeutics

(2013) Alejandro Santillan et al.   JOURNAL OF NEUROSCIENCE METHODS

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Distinct effects of inflammation on gliosis, osmohomeostasis, and vascular integrity during amyloid beta-induced retinal degeneration

(2012) Virginie Dinet et al.   AGING CELL

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Effects of Static Accommodation Versus Repeated Accommodation on Intraocular Pressure

(2010) Frank Jenssen et al.   JOURNAL OF GLAUCOMA

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema

(2010) A. S. Thrane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in intraocular pressure and ocular pulse amplitude with accommodation

(2009) S. A Read et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Identification of lymphatics in the ciliary body of the human eye: A novel “uveolymphatic” outflow pathway

(2009) Yeni H. Yücel et al.   EXPERIMENTAL EYE RESEARCH

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma

(2008) B. P. Buckingham et al.   JOURNAL OF NEUROSCIENCE