Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch

The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

(2020) Ahmad Abdelzaher Zaki Khalifa et al.   eLife

Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock

(2019) Takahiro N. Uehara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora

(2019) Xiao Liu et al.   Nature Communications

TwoCk1δtranscripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock

(2018) Jean-Michel Fustin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

(2018) Rajesh Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ASK family kinases mediate cellular stress and redox signaling to circadian clock

(2018) Kiyomichi Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CK1α Collaborates with DOUBLETIME to Regulate PERIOD Function in the Drosophila Circadian Clock

(2018) Vu H. Lam et al.   JOURNAL OF NEUROSCIENCE

Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

(2018) JingJing Liu et al.   Science Signaling

Macromolecular Assemblies of the Mammalian Circadian Clock

(2017) Rajindra P. Aryal et al.   MOLECULAR CELL

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock

(2017) Yuta Shinohara et al.   MOLECULAR CELL

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

The intricate dance of post-translational modifications in the rhythm of life

(2016) Arisa Hirano et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The intricate dance of post-translational modifications in the rhythm of life

(2016) Arisa Hirano et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period

(2015) Min Zhou et al.   MOLECULAR CELL

Decoupling circadian clock protein turnover from circadian period determination

(2015) L. F. Larrondo et al.   SCIENCE

GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins

(2015) Neel Mehta et al.   Cell Reports

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

(2014) Rui Ye et al.   GENES & DEVELOPMENT

The Tau Mutation of Casein Kinase 1ϵ Sets the Period of the Mammalian Pacemaker via Regulation of Period1 or Period2 Clock Proteins

(2014) E.S. Maywood et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex

(2014) Shannon N Nangle et al.   eLife

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

(2013) Weiman Xing et al.   NATURE

Casein Kinase I  Mutations in Familial Migraine and Advanced Sleep Phase

(2013) K. C. Brennan et al.   Science Translational Medicine

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability

(2011) Naval P. Shanware et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock

(2011) Rui Ye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian Conformational Change of the Neurospora Clock Protein FREQUENCY Triggered by Clustered Hyperphosphorylation of a Basic Domain

(2011) Christina Querfurth et al.   MOLECULAR CELL

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

(2010) Q.-J. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

(2010) Tsuyoshi Hirota et al.   PLOS BIOLOGY

Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription

(2009) H. Yoshitane et al.   MOLECULAR AND CELLULAR BIOLOGY

Rhythmic PER Abundance Defines a Critical Nodal Point for Negative Feedback within the Circadian Clock Mechanism

(2009) Rongmin Chen et al.   MOLECULAR CELL

Interactions between Casein Kinase Iε (CKIε) and Two Substrates from Disparate Signaling Pathways Reveal Mechanisms for Substrate-Kinase Specificity

(2009) Caroline Lund Dahlberg et al.   PLoS One

Essential roles of CKIδ and CKIε in the mammalian circadian clock

(2009) Hyeongmin Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CKI / -dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

(2009) Y. Isojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of the Protein Kinase CK2 in the Regulation of Mammalian Circadian Rhythms

(2009) Y. Tsuchiya et al.   Science Signaling

The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2

(2008) Kanae Ohsaki et al.   JOURNAL OF BIOCHEMISTRY