A paradigm of thermal adaptation in penguins and elephants by tuning cold activation in TRPM8

Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel

(2019) Ying Yin et al.   SCIENCE

Molecular basis for heat desensitization of TRPV1 ion channels

(2019) Lei Luo et al.   Nature Communications

Structural insights into TRPM8 inhibition and desensitization

(2019) Melinda M. Diver et al.   SCIENCE

The ion selectivity filter is not an activation gate in TRPV1-3 channels

(2019) Andrés Jara-Oseguera et al.   eLife

TRP Channels as Potential Drug Targets

(2018) Magdalene M. Moran   Annual Review of Pharmacology and Toxicology

Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison

(2018) María Pertusa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat activation is intrinsic to the pore domain of TRPV1

(2017) Feng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters

(2017) Vanessa Matos-Cruz et al.   Cell Reports

TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity

(2017) Jason O. Sosa-Pagán et al.   Scientific Reports

Characterizing hydrophobicity of amino acid side chains in a protein environment via measuring contact angle of a water nanodroplet on planar peptide network

(2016) Chongqin Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels

(2016) Willem J. Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

(2015) Fan Yang et al.   Nature Chemical Biology

A Molecular Framework for Temperature-Dependent Gating of Ion Channels

(2014) Sandipan Chowdhury et al.   CELL

Temperature and Voltage Coupling to Channel Opening in Transient Receptor Potential Melastatin 8 (TRPM8)

(2014) Natalia Raddatz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Genetically Encoded Fluorescent Probe in Mammalian Cells

(2013) Abhishek Chatterjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Species differences and molecular determinant of TRPA1 cold sensitivity

(2013) Jun Chen et al.   Nature Communications

Knowledge-Based Potential for Positioning Membrane-Associated Structures and Assessing Residue-Specific Energetic Contributions

(2012) Chaim A. Schramm et al.   STRUCTURE

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

(2011) D. E. Clapham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Side-chain hydrophobicity scale derived from transmembrane protein folding into lipid bilayers

(2011) C. P. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

(2010) Jörg Grandl et al.   NATURE NEUROSCIENCE

Thermosensitive TRP channel pore turret is part of the temperature activation pathway

(2010) F. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Thermal Response Properties in a Cold-Activated TRP Channel

(2009) Benjamin R. Myers et al.   PLoS One

Pore region of TRPV3 ion channel is specifically required for heat activation

(2008) Jörg Grandl et al.   NATURE NEUROSCIENCE